Theranostic applications of phage display to control leishmaniasis: Selection of biomarkers for serodiagnostics, vaccination, and immunotherapy

Phage display is a high-throughput subtractive proteomic technology used for the generation and screening of large peptide and antibody libraries. It is based on the selection of phage-fused surface-exposed peptides that recognize specific ligands and demonstrate desired functionality for diagnostic...

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Detalhes bibliográficos
Autores: Goulart, Luiz Ricardo, Soto Álvarez, Manuel, Tavares, Carlos Alberto Pereira, Costa, Lourena Emanuele, Chávez-Fumagalli, Miguel Angel, Coelho, Eduardo Antonio Ferraz
Tipo de documento: artigo
Data de publicação:2015
País:España
Recursos:Universidad Autónoma de Madrid
Repositório:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglês
OAI Identifier:oai:repositorio.uam.es:10486/675362
Acesso em linha:http://hdl.handle.net/10486/675362
https://dx.doi.org/10.1590/0037-8682-0096-2015
Access Level:Acceso aberto
Palavra-chave:Mimotopes
Phage display
Serodiagnosis
Vaccine
Visceral leishmaniasis
Biología y Biomedicina / Biología
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spelling Theranostic applications of phage display to control leishmaniasis: Selection of biomarkers for serodiagnostics, vaccination, and immunotherapyGoulart, Luiz RicardoSoto Álvarez, ManuelTavares, Carlos Alberto PereiraCosta, Lourena EmanueleChávez-Fumagalli, Miguel AngelCoelho, Eduardo Antonio FerrazMimotopesPhage displaySerodiagnosisVaccineVisceral leishmaniasisBiología y Biomedicina / BiologíaPhage display is a high-throughput subtractive proteomic technology used for the generation and screening of large peptide and antibody libraries. It is based on the selection of phage-fused surface-exposed peptides that recognize specific ligands and demonstrate desired functionality for diagnostic and therapeutic purposes. Phage display has provided unmatched tools for controlling viral, bacterial, fungal, and parasitic infections, and allowed identification of new therapeutic targets to treat cancer, metabolic diseases, and other chronic conditions. This review presents recent advancements in serodiagnostics and prevention of leishmaniasis -an important tropical parasitic disease- achieved using phage display for the identification of novel antigens with improved sensitivity and specificity. Our focus is on theranostics of visceral leishmaniasis with the aim to develop biomarker candidates exhibiting both diagnostic and therapeutic potential to fight this important, yet neglected, tropical diseaseSociedade Brasileira de Medicina TropicalDepartamento de Biología MolecularFacultad de Ciencias20152015-07-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/675362https://dx.doi.org/10.1590/0037-8682-0096-2015reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6753622026-06-23T12:46:27Z
dc.title.none.fl_str_mv Theranostic applications of phage display to control leishmaniasis: Selection of biomarkers for serodiagnostics, vaccination, and immunotherapy
title Theranostic applications of phage display to control leishmaniasis: Selection of biomarkers for serodiagnostics, vaccination, and immunotherapy
spellingShingle Theranostic applications of phage display to control leishmaniasis: Selection of biomarkers for serodiagnostics, vaccination, and immunotherapy
Goulart, Luiz Ricardo
Mimotopes
Phage display
Serodiagnosis
Vaccine
Visceral leishmaniasis
Biología y Biomedicina / Biología
title_short Theranostic applications of phage display to control leishmaniasis: Selection of biomarkers for serodiagnostics, vaccination, and immunotherapy
title_full Theranostic applications of phage display to control leishmaniasis: Selection of biomarkers for serodiagnostics, vaccination, and immunotherapy
title_fullStr Theranostic applications of phage display to control leishmaniasis: Selection of biomarkers for serodiagnostics, vaccination, and immunotherapy
title_full_unstemmed Theranostic applications of phage display to control leishmaniasis: Selection of biomarkers for serodiagnostics, vaccination, and immunotherapy
title_sort Theranostic applications of phage display to control leishmaniasis: Selection of biomarkers for serodiagnostics, vaccination, and immunotherapy
dc.creator.none.fl_str_mv Goulart, Luiz Ricardo
Soto Álvarez, Manuel
Tavares, Carlos Alberto Pereira
Costa, Lourena Emanuele
Chávez-Fumagalli, Miguel Angel
Coelho, Eduardo Antonio Ferraz
author Goulart, Luiz Ricardo
author_facet Goulart, Luiz Ricardo
Soto Álvarez, Manuel
Tavares, Carlos Alberto Pereira
Costa, Lourena Emanuele
Chávez-Fumagalli, Miguel Angel
Coelho, Eduardo Antonio Ferraz
author_role author
author2 Soto Álvarez, Manuel
Tavares, Carlos Alberto Pereira
Costa, Lourena Emanuele
Chávez-Fumagalli, Miguel Angel
Coelho, Eduardo Antonio Ferraz
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Biología Molecular
Facultad de Ciencias
dc.subject.none.fl_str_mv Mimotopes
Phage display
Serodiagnosis
Vaccine
Visceral leishmaniasis
Biología y Biomedicina / Biología
topic Mimotopes
Phage display
Serodiagnosis
Vaccine
Visceral leishmaniasis
Biología y Biomedicina / Biología
description Phage display is a high-throughput subtractive proteomic technology used for the generation and screening of large peptide and antibody libraries. It is based on the selection of phage-fused surface-exposed peptides that recognize specific ligands and demonstrate desired functionality for diagnostic and therapeutic purposes. Phage display has provided unmatched tools for controlling viral, bacterial, fungal, and parasitic infections, and allowed identification of new therapeutic targets to treat cancer, metabolic diseases, and other chronic conditions. This review presents recent advancements in serodiagnostics and prevention of leishmaniasis -an important tropical parasitic disease- achieved using phage display for the identification of novel antigens with improved sensitivity and specificity. Our focus is on theranostics of visceral leishmaniasis with the aim to develop biomarker candidates exhibiting both diagnostic and therapeutic potential to fight this important, yet neglected, tropical disease
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-07-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/675362
https://dx.doi.org/10.1590/0037-8682-0096-2015
url http://hdl.handle.net/10486/675362
https://dx.doi.org/10.1590/0037-8682-0096-2015
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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