Comparison of different GC-MS configurations for the determination of prevalent drugs and related metabolites

Cocaine, cannabis, heroin, and other opioids are among the prevalent drugs in Europe. The use of these drugs is demonstrated by the determination of either parent drugs or related metabolites in a variety of biological samples. Various analytical methodologies can be applied for this purpose, all of...

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Detalles Bibliográficos
Autores: Saiz Galindo, Jorge, García Ruiz, Carmen|||0000-0001-5925-3449, Gómara Moreno, Belén
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/48607
Acceso en línea:http://hdl.handle.net/10017/48607
https://dx.doi.org/10.1039/C7AY00813A
Access Level:acceso abierto
Palabra clave:GC-MS
Cocaine
Heroin
Cannabis
Opioids
Química
Chemistry
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spelling Comparison of different GC-MS configurations for the determination of prevalent drugs and related metabolitesSaiz Galindo, JorgeGarcía Ruiz, Carmen|||0000-0001-5925-3449Gómara Moreno, BelénGC-MSCocaineHeroinCannabisOpioidsQuímicaChemistryCocaine, cannabis, heroin, and other opioids are among the prevalent drugs in Europe. The use of these drugs is demonstrated by the determination of either parent drugs or related metabolites in a variety of biological samples. Various analytical methodologies can be applied for this purpose, all of which might show relevant differences in analytical performance. In this work we used different GC-MS configurations for the quantitation of cocaine, cocaethylene, benzoylecgonine, morphine, and Delta9-tetrahydrocannabinol with the aim of comparing the analytical performance of different GC-MS instruments, different injectors, ion sources, ionization modes, mass analyzers, operating modes, and acquisition modes, in order to find the optimal configuration in terms of sensitivity and precision. Other important factors, such as the derivatization process for GC analysis or the injection mode, were also investigated for the same purpose. A comparative study of different methods used for the calculation of the limits of detection was also performed, in order to compare them in terms of the obtained values and their veracity. Differences found in the results obtained with different configurations showed different limits of detection and different precision. These results allowed us to indicate advantages and limitations, which depended on the configuration of the GC-MS used. Finally, differences up to seven orders of magnitude were found in the LOD values obtained with different methods, some of them being too small to show any measurable peak.Instituto Universitario de Investigación en Ciencias PolicialesUniversidad de Alcalá20172017-04-12journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/48607https://dx.doi.org/10.1039/C7AY00813Areponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengIUICP Not available IUICP-2016-003 Screening (cribado) de tóxicos mediante cromatografía líquida acoplada a espectrometría de masas con analizador de cuadrupolo y trampa (LC-Q-TRAP-MS) en muestras de sangre total-plasma-sueroopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/486072026-06-18T11:13:07Z
dc.title.none.fl_str_mv Comparison of different GC-MS configurations for the determination of prevalent drugs and related metabolites
title Comparison of different GC-MS configurations for the determination of prevalent drugs and related metabolites
spellingShingle Comparison of different GC-MS configurations for the determination of prevalent drugs and related metabolites
Saiz Galindo, Jorge
GC-MS
Cocaine
Heroin
Cannabis
Opioids
Química
Chemistry
title_short Comparison of different GC-MS configurations for the determination of prevalent drugs and related metabolites
title_full Comparison of different GC-MS configurations for the determination of prevalent drugs and related metabolites
title_fullStr Comparison of different GC-MS configurations for the determination of prevalent drugs and related metabolites
title_full_unstemmed Comparison of different GC-MS configurations for the determination of prevalent drugs and related metabolites
title_sort Comparison of different GC-MS configurations for the determination of prevalent drugs and related metabolites
dc.creator.none.fl_str_mv Saiz Galindo, Jorge
García Ruiz, Carmen|||0000-0001-5925-3449
Gómara Moreno, Belén
author Saiz Galindo, Jorge
author_facet Saiz Galindo, Jorge
García Ruiz, Carmen|||0000-0001-5925-3449
Gómara Moreno, Belén
author_role author
author2 García Ruiz, Carmen|||0000-0001-5925-3449
Gómara Moreno, Belén
author2_role author
author
dc.subject.none.fl_str_mv GC-MS
Cocaine
Heroin
Cannabis
Opioids
Química
Chemistry
topic GC-MS
Cocaine
Heroin
Cannabis
Opioids
Química
Chemistry
description Cocaine, cannabis, heroin, and other opioids are among the prevalent drugs in Europe. The use of these drugs is demonstrated by the determination of either parent drugs or related metabolites in a variety of biological samples. Various analytical methodologies can be applied for this purpose, all of which might show relevant differences in analytical performance. In this work we used different GC-MS configurations for the quantitation of cocaine, cocaethylene, benzoylecgonine, morphine, and Delta9-tetrahydrocannabinol with the aim of comparing the analytical performance of different GC-MS instruments, different injectors, ion sources, ionization modes, mass analyzers, operating modes, and acquisition modes, in order to find the optimal configuration in terms of sensitivity and precision. Other important factors, such as the derivatization process for GC analysis or the injection mode, were also investigated for the same purpose. A comparative study of different methods used for the calculation of the limits of detection was also performed, in order to compare them in terms of the obtained values and their veracity. Differences found in the results obtained with different configurations showed different limits of detection and different precision. These results allowed us to indicate advantages and limitations, which depended on the configuration of the GC-MS used. Finally, differences up to seven orders of magnitude were found in the LOD values obtained with different methods, some of them being too small to show any measurable peak.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-04-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/48607
https://dx.doi.org/10.1039/C7AY00813A
url http://hdl.handle.net/10017/48607
https://dx.doi.org/10.1039/C7AY00813A
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv IUICP Not available IUICP-2016-003 Screening (cribado) de tóxicos mediante cromatografía líquida acoplada a espectrometría de masas con analizador de cuadrupolo y trampa (LC-Q-TRAP-MS) en muestras de sangre total-plasma-suero
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
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