Adult height in girls with idiopathic premature adrenarche: A cohort study and design of a predictive model

Idiopathic premature adrenarche (IPA) is considered a normal variant of puberty, presenting more commonly in female patients. There are concerns as to whether IPA alters the final height of these girls. Our main objectives were to (a) compare the adult height of girls with IPA against their target h...

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Autores: Mejorado-Molano, Francisco Javier, Sanz Calvo, María Luisa, Posada Ayala, Ana, Caballo Roig, Nieves, Gavela Pérez, Teresa, Mahíllo Fernández, Ignacio, Soriano Guillén, Leandro
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/712832
Acceso en línea:http://hdl.handle.net/10486/712832
https://dx.doi.org/10.3389/fendo.2022.852422
Access Level:acceso abierto
Palabra clave:idiopathic premature adrenarche
adult height
target heigh
adult height predictive models
multiple regression analysis
Medicina
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spelling Adult height in girls with idiopathic premature adrenarche: A cohort study and design of a predictive modelMejorado-Molano, Francisco JavierSanz Calvo, María LuisaPosada Ayala, AnaCaballo Roig, NievesGavela Pérez, TeresaMahíllo Fernández, IgnacioSoriano Guillén, Leandroidiopathic premature adrenarcheadult heighttarget heighadult height predictive modelsmultiple regression analysisMedicinaIdiopathic premature adrenarche (IPA) is considered a normal variant of puberty, presenting more commonly in female patients. There are concerns as to whether IPA alters the final height of these girls. Our main objectives were to (a) compare the adult height of girls with IPA against their target height and (b) design a mathematical model to predict adult height at diagnosis in female patients with IPA. Materials and Methods: A cohort study of girls with IPA was conducted from the time of IPA diagnosis until adult height. The following data were collected: target height, perinatal history, anthropometric and biochemical variables and bone age at diagnosis, age at Tanner stage 2 and menarcheal age, and adult height. First, we performed a univariate statistical analysis after which we carried out a multiple linear regression analysis using adult height as the dependent variable. Results: We obtained data from 79 female patients diagnosed with IPA with a mean adult height of 164.6 cm (95% CI: 163.36–165.85 cm). The mean follow-up time was 6.60 years. Average age at Tanner stage 2 was 9.71 years. Mean menarcheal age was 11.64 years. There were no significant differences between target height and adult height. Of the several predictive models designed for these patients, one of them, which included bone age, obtained an R2 value of 71%. Conclusions: Although slightly advanced puberty was observed among the girls with IPA, their adult height was preserved. The use of predictive models of adult height on diagnosis of IPA could facilitate closer follow-up of girls at risk of reduced adult heightFrontiers MediaDepartamento de PediatríaFacultad de Medicina20222022-03-03research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/712832https://dx.doi.org/10.3389/fendo.2022.852422reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7128322026-06-23T12:46:27Z
dc.title.none.fl_str_mv Adult height in girls with idiopathic premature adrenarche: A cohort study and design of a predictive model
title Adult height in girls with idiopathic premature adrenarche: A cohort study and design of a predictive model
spellingShingle Adult height in girls with idiopathic premature adrenarche: A cohort study and design of a predictive model
Mejorado-Molano, Francisco Javier
idiopathic premature adrenarche
adult height
target heigh
adult height predictive models
multiple regression analysis
Medicina
title_short Adult height in girls with idiopathic premature adrenarche: A cohort study and design of a predictive model
title_full Adult height in girls with idiopathic premature adrenarche: A cohort study and design of a predictive model
title_fullStr Adult height in girls with idiopathic premature adrenarche: A cohort study and design of a predictive model
title_full_unstemmed Adult height in girls with idiopathic premature adrenarche: A cohort study and design of a predictive model
title_sort Adult height in girls with idiopathic premature adrenarche: A cohort study and design of a predictive model
dc.creator.none.fl_str_mv Mejorado-Molano, Francisco Javier
Sanz Calvo, María Luisa
Posada Ayala, Ana
Caballo Roig, Nieves
Gavela Pérez, Teresa
Mahíllo Fernández, Ignacio
Soriano Guillén, Leandro
author Mejorado-Molano, Francisco Javier
author_facet Mejorado-Molano, Francisco Javier
Sanz Calvo, María Luisa
Posada Ayala, Ana
Caballo Roig, Nieves
Gavela Pérez, Teresa
Mahíllo Fernández, Ignacio
Soriano Guillén, Leandro
author_role author
author2 Sanz Calvo, María Luisa
Posada Ayala, Ana
Caballo Roig, Nieves
Gavela Pérez, Teresa
Mahíllo Fernández, Ignacio
Soriano Guillén, Leandro
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Pediatría
Facultad de Medicina
dc.subject.none.fl_str_mv idiopathic premature adrenarche
adult height
target heigh
adult height predictive models
multiple regression analysis
Medicina
topic idiopathic premature adrenarche
adult height
target heigh
adult height predictive models
multiple regression analysis
Medicina
description Idiopathic premature adrenarche (IPA) is considered a normal variant of puberty, presenting more commonly in female patients. There are concerns as to whether IPA alters the final height of these girls. Our main objectives were to (a) compare the adult height of girls with IPA against their target height and (b) design a mathematical model to predict adult height at diagnosis in female patients with IPA. Materials and Methods: A cohort study of girls with IPA was conducted from the time of IPA diagnosis until adult height. The following data were collected: target height, perinatal history, anthropometric and biochemical variables and bone age at diagnosis, age at Tanner stage 2 and menarcheal age, and adult height. First, we performed a univariate statistical analysis after which we carried out a multiple linear regression analysis using adult height as the dependent variable. Results: We obtained data from 79 female patients diagnosed with IPA with a mean adult height of 164.6 cm (95% CI: 163.36–165.85 cm). The mean follow-up time was 6.60 years. Average age at Tanner stage 2 was 9.71 years. Mean menarcheal age was 11.64 years. There were no significant differences between target height and adult height. Of the several predictive models designed for these patients, one of them, which included bone age, obtained an R2 value of 71%. Conclusions: Although slightly advanced puberty was observed among the girls with IPA, their adult height was preserved. The use of predictive models of adult height on diagnosis of IPA could facilitate closer follow-up of girls at risk of reduced adult height
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-03-03
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/712832
https://dx.doi.org/10.3389/fendo.2022.852422
url http://hdl.handle.net/10486/712832
https://dx.doi.org/10.3389/fendo.2022.852422
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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