Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium

Although there is a clear relationship between family history (FH) and the risk of gastric cancer (GC), quantification is still needed in relation to different histological types and anatomical sites, and in strata of covariates. The objective was to analyze the risk of GC according to first-degree...

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Autores: Vitelli Storelli, Facundo, Rubín García, María, Pelucchi, Claudio, Benavente, Yolanda, Bonzi, Rossella, Rota, Matteo, Palli, Domenico, Ferraroni, Monica, Lunet, Nuno, Morais, Samantha, Ye, Weimin, Plymoth, Amelie, Malekzadeh, Reza, Tsugane, Shoichiro, Hidaka, Akihisa, Aragonès Sanz, Núria, Castaño-Vinyals, Gemma, Zaridze, David, Maximovich, Dmitry, Vioque, Jesús, García de la Hera, Manuela, Zhang, Zuo-feng, Shigueaki Hamada, Gerson, Pakseresht, Mohammadreza, Pourfarzi, Farhad, Mu, Lina, Boccia, Stefania, Pastorino, Roberta, Yu, Guo-Pei, Lagiou, Areti, Lagiou, Pagona, Negri, Eva, La Vecchia, Carlo, Martín Sánchez, Vicente
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/179953
Acesso em linha:https://hdl.handle.net/2445/179953
Access Level:Acceso aberto
Palavra-chave:Càncer d'estómac
Històries clíniques
Stomach cancer
Medical records
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spelling Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project ConsortiumVitelli Storelli, FacundoRubín García, MaríaPelucchi, ClaudioBenavente, YolandaBonzi, RossellaRota, MatteoPalli, DomenicoFerraroni, MonicaLunet, NunoMorais, SamanthaYe, WeiminPlymoth, AmelieMalekzadeh, RezaTsugane, ShoichiroHidaka, AkihisaAragonès Sanz, NúriaCastaño-Vinyals, GemmaZaridze, DavidMaximovich, DmitryVioque, JesúsGarcía de la Hera, ManuelaZhang, Zuo-fengShigueaki Hamada, GersonPakseresht, MohammadrezaPourfarzi, FarhadMu, LinaBoccia, StefaniaPastorino, RobertaYu, Guo-PeiLagiou, AretiLagiou, PagonaNegri, EvaLa Vecchia, CarloMartín Sánchez, VicenteCàncer d'estómacHistòries clíniquesStomach cancerMedical recordsAlthough there is a clear relationship between family history (FH) and the risk of gastric cancer (GC), quantification is still needed in relation to different histological types and anatomical sites, and in strata of covariates. The objective was to analyze the risk of GC according to first-degree FH in a uniquely large epidemiological consortium of GC. This investigation includes 5946 cases and 12,776 controls from 17 studies of the Stomach Cancer Pooling (StoP) Project consortium. Summary odds ratios (OR) and the corresponding 95% confidence intervals (CIs) were calculated by pooling study-specific ORs using fixed-effect model meta-analysis techniques. Stratified analyses were carried out by sex, age, tumor location and histological type, smoking habit, socioeconomic status, alcohol intake and fruit consumption. The pooled OR for GC was 1.84 (95% CI: 1.64-2.04; I2 = 6.1%, P heterogeneity = 0.383) in subjects with vs. those without first-degree relatives with GC. No significant differences were observed among subgroups of sex, age, geographic area or study period. Associations tended to be stronger for non-cardia (OR = 1.82; 95% CI: 1.59-2.05 for subjects with FH) than for cardia GC (OR = 1.38; 95% CI: 0.98-1.77), and for the intestinal (OR = 1.92; 95% CI: 1.62-2.23) than for the diffuse histotype (OR = 1.62; 95% CI: 1.28-1.96). This analysis confirms the effect of FH on the risk of GC, reporting an approximately doubled risk, and provides further quantification of the risk of GC according to the subsite and histotype. Considering these findings, accounting for the presence of FH to carry out correct prevention and diagnosis measures is of the utmost importance.MDPI AG2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/179953Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/cancers13153844Cancers, 2021, vol. 13, num. 15, p. 3844https://doi.org/10.3390/cancers13153844cc by (c) Vitelli Storelli, Facundo et al, 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1799532026-05-27T06:46:51Z
dc.title.none.fl_str_mv Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium
title Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium
spellingShingle Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium
Vitelli Storelli, Facundo
Càncer d'estómac
Històries clíniques
Stomach cancer
Medical records
title_short Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium
title_full Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium
title_fullStr Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium
title_full_unstemmed Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium
title_sort Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium
dc.creator.none.fl_str_mv Vitelli Storelli, Facundo
Rubín García, María
Pelucchi, Claudio
Benavente, Yolanda
Bonzi, Rossella
Rota, Matteo
Palli, Domenico
Ferraroni, Monica
Lunet, Nuno
Morais, Samantha
Ye, Weimin
Plymoth, Amelie
Malekzadeh, Reza
Tsugane, Shoichiro
Hidaka, Akihisa
Aragonès Sanz, Núria
Castaño-Vinyals, Gemma
Zaridze, David
Maximovich, Dmitry
Vioque, Jesús
García de la Hera, Manuela
Zhang, Zuo-feng
Shigueaki Hamada, Gerson
Pakseresht, Mohammadreza
Pourfarzi, Farhad
Mu, Lina
Boccia, Stefania
Pastorino, Roberta
Yu, Guo-Pei
Lagiou, Areti
Lagiou, Pagona
Negri, Eva
La Vecchia, Carlo
Martín Sánchez, Vicente
author Vitelli Storelli, Facundo
author_facet Vitelli Storelli, Facundo
Rubín García, María
Pelucchi, Claudio
Benavente, Yolanda
Bonzi, Rossella
Rota, Matteo
Palli, Domenico
Ferraroni, Monica
Lunet, Nuno
Morais, Samantha
Ye, Weimin
Plymoth, Amelie
Malekzadeh, Reza
Tsugane, Shoichiro
Hidaka, Akihisa
Aragonès Sanz, Núria
Castaño-Vinyals, Gemma
Zaridze, David
Maximovich, Dmitry
Vioque, Jesús
García de la Hera, Manuela
Zhang, Zuo-feng
Shigueaki Hamada, Gerson
Pakseresht, Mohammadreza
Pourfarzi, Farhad
Mu, Lina
Boccia, Stefania
Pastorino, Roberta
Yu, Guo-Pei
Lagiou, Areti
Lagiou, Pagona
Negri, Eva
La Vecchia, Carlo
Martín Sánchez, Vicente
author_role author
author2 Rubín García, María
Pelucchi, Claudio
Benavente, Yolanda
Bonzi, Rossella
Rota, Matteo
Palli, Domenico
Ferraroni, Monica
Lunet, Nuno
Morais, Samantha
Ye, Weimin
Plymoth, Amelie
Malekzadeh, Reza
Tsugane, Shoichiro
Hidaka, Akihisa
Aragonès Sanz, Núria
Castaño-Vinyals, Gemma
Zaridze, David
Maximovich, Dmitry
Vioque, Jesús
García de la Hera, Manuela
Zhang, Zuo-feng
Shigueaki Hamada, Gerson
Pakseresht, Mohammadreza
Pourfarzi, Farhad
Mu, Lina
Boccia, Stefania
Pastorino, Roberta
Yu, Guo-Pei
Lagiou, Areti
Lagiou, Pagona
Negri, Eva
La Vecchia, Carlo
Martín Sánchez, Vicente
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer d'estómac
Històries clíniques
Stomach cancer
Medical records
topic Càncer d'estómac
Històries clíniques
Stomach cancer
Medical records
description Although there is a clear relationship between family history (FH) and the risk of gastric cancer (GC), quantification is still needed in relation to different histological types and anatomical sites, and in strata of covariates. The objective was to analyze the risk of GC according to first-degree FH in a uniquely large epidemiological consortium of GC. This investigation includes 5946 cases and 12,776 controls from 17 studies of the Stomach Cancer Pooling (StoP) Project consortium. Summary odds ratios (OR) and the corresponding 95% confidence intervals (CIs) were calculated by pooling study-specific ORs using fixed-effect model meta-analysis techniques. Stratified analyses were carried out by sex, age, tumor location and histological type, smoking habit, socioeconomic status, alcohol intake and fruit consumption. The pooled OR for GC was 1.84 (95% CI: 1.64-2.04; I2 = 6.1%, P heterogeneity = 0.383) in subjects with vs. those without first-degree relatives with GC. No significant differences were observed among subgroups of sex, age, geographic area or study period. Associations tended to be stronger for non-cardia (OR = 1.82; 95% CI: 1.59-2.05 for subjects with FH) than for cardia GC (OR = 1.38; 95% CI: 0.98-1.77), and for the intestinal (OR = 1.92; 95% CI: 1.62-2.23) than for the diffuse histotype (OR = 1.62; 95% CI: 1.28-1.96). This analysis confirms the effect of FH on the risk of GC, reporting an approximately doubled risk, and provides further quantification of the risk of GC according to the subsite and histotype. Considering these findings, accounting for the presence of FH to carry out correct prevention and diagnosis measures is of the utmost importance.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/179953
url https://hdl.handle.net/2445/179953
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/cancers13153844
Cancers, 2021, vol. 13, num. 15, p. 3844
https://doi.org/10.3390/cancers13153844
dc.rights.none.fl_str_mv cc by (c) Vitelli Storelli, Facundo et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Vitelli Storelli, Facundo et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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