The p38 pathway: From biology to cancer therapy

The p38 MAPK pathway is well known for its role in transducing stress signals from the environment. Many key players and regulatory mechanisms of this signaling cascade have been described to some extent. Nevertheless, p38 participates in a broad range of cellular activities, for many of which detai...

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Detalhes bibliográficos
Autores: Martínez Limón, Adrián, Joaquin i Caudet, Manel, Caballero de la Torre, María, Posas, Francesc, Nadal Clanchet, Eulàlia de
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/220512
Acesso em linha:https://hdl.handle.net/2445/220512
Access Level:acceso abierto
Palavra-chave:Terapèutica
Càncer
Fosforilació
Proteïnes supressores de tumors
Therapeutics
Cancer
Phosphorylation
Tumor suppressor protein
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spelling The p38 pathway: From biology to cancer therapyMartínez Limón, AdriánJoaquin i Caudet, ManelCaballero de la Torre, MaríaPosas, FrancescNadal Clanchet, Eulàlia deTerapèuticaCàncerFosforilacióProteïnes supressores de tumorsTherapeuticsCancerPhosphorylationTumor suppressor proteinThe p38 MAPK pathway is well known for its role in transducing stress signals from the environment. Many key players and regulatory mechanisms of this signaling cascade have been described to some extent. Nevertheless, p38 participates in a broad range of cellular activities, for many of which detailed molecular pictures are still lacking. Originally described as a tumor-suppressor kinase for its inhibitory role in RAS-dependent transformation, p38 can also function as a tumor promoter, as demonstrated by extensive experimental data. This finding has prompted the development of specific inhibitors that have been used in clinical trials to treat several human malignancies, although without much success to date. However, elucidating critical aspects of p38 biology, such as isoform-specific functions or its apparent dual nature during tumorigenesis, might open up new possibilities for therapy with unexpected potential. In this review, we provide an extensive description of the main biological functions of p38 and focus on recent studies that have addressed its role in cancer. Furthermore, we provide an updated overview of therapeutic strategies targeting p38 in cancer and promising alternatives currently being explored.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/220512Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/ijms21061913International Journal Of Molecular Sciences, 2020, vol. 21, num. 6https://doi.org/10.3390/ijms21061913cc-by (c) Martínez Limón, Adrián et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2205122026-05-27T06:46:51Z
dc.title.none.fl_str_mv The p38 pathway: From biology to cancer therapy
title The p38 pathway: From biology to cancer therapy
spellingShingle The p38 pathway: From biology to cancer therapy
Martínez Limón, Adrián
Terapèutica
Càncer
Fosforilació
Proteïnes supressores de tumors
Therapeutics
Cancer
Phosphorylation
Tumor suppressor protein
title_short The p38 pathway: From biology to cancer therapy
title_full The p38 pathway: From biology to cancer therapy
title_fullStr The p38 pathway: From biology to cancer therapy
title_full_unstemmed The p38 pathway: From biology to cancer therapy
title_sort The p38 pathway: From biology to cancer therapy
dc.creator.none.fl_str_mv Martínez Limón, Adrián
Joaquin i Caudet, Manel
Caballero de la Torre, María
Posas, Francesc
Nadal Clanchet, Eulàlia de
author Martínez Limón, Adrián
author_facet Martínez Limón, Adrián
Joaquin i Caudet, Manel
Caballero de la Torre, María
Posas, Francesc
Nadal Clanchet, Eulàlia de
author_role author
author2 Joaquin i Caudet, Manel
Caballero de la Torre, María
Posas, Francesc
Nadal Clanchet, Eulàlia de
author2_role author
author
author
author
dc.subject.none.fl_str_mv Terapèutica
Càncer
Fosforilació
Proteïnes supressores de tumors
Therapeutics
Cancer
Phosphorylation
Tumor suppressor protein
topic Terapèutica
Càncer
Fosforilació
Proteïnes supressores de tumors
Therapeutics
Cancer
Phosphorylation
Tumor suppressor protein
description The p38 MAPK pathway is well known for its role in transducing stress signals from the environment. Many key players and regulatory mechanisms of this signaling cascade have been described to some extent. Nevertheless, p38 participates in a broad range of cellular activities, for many of which detailed molecular pictures are still lacking. Originally described as a tumor-suppressor kinase for its inhibitory role in RAS-dependent transformation, p38 can also function as a tumor promoter, as demonstrated by extensive experimental data. This finding has prompted the development of specific inhibitors that have been used in clinical trials to treat several human malignancies, although without much success to date. However, elucidating critical aspects of p38 biology, such as isoform-specific functions or its apparent dual nature during tumorigenesis, might open up new possibilities for therapy with unexpected potential. In this review, we provide an extensive description of the main biological functions of p38 and focus on recent studies that have addressed its role in cancer. Furthermore, we provide an updated overview of therapeutic strategies targeting p38 in cancer and promising alternatives currently being explored.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/220512
url https://hdl.handle.net/2445/220512
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms21061913
International Journal Of Molecular Sciences, 2020, vol. 21, num. 6
https://doi.org/10.3390/ijms21061913
dc.rights.none.fl_str_mv cc-by (c) Martínez Limón, Adrián et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Martínez Limón, Adrián et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,223283

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