Fat loss in continuous enteral feeding of the preterm infant: How much, what and when is it lost?

Human milk fat is a concentrated source of energy and provides essential and long chain polyunsaturated fatty acids. According to previous experiments, human milk fat is partially lost during continuous enteral nutrition. However, these experiments were done over relatively short infusion times, and...

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Authors: Zozaya, Carlos, García-Serrano, Alba M., Fontecha, F. Javier, Redondo-Bravo, Lidia, Sánchez-González, Victoria, Montes, María Teresa, Saenz de Pipaón, Miguel
Format: article
Status:Published version
Publication Date:2018
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/167936
Online Access:http://hdl.handle.net/10261/167936
Access Level:Open access
Keyword:Preterm infant
Enteral nutrition
Lipids
Omega-3 fatty acids
Omega-6 fatty acids
Docosahexaenoic acid
Arachidonic acid
Long-chain polyunsaturated fatty acids
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spelling Fat loss in continuous enteral feeding of the preterm infant: How much, what and when is it lost?Zozaya, CarlosGarcía-Serrano, Alba M.Fontecha, F. JavierRedondo-Bravo, LidiaSánchez-González, VictoriaMontes, María TeresaSaenz de Pipaón, MiguelPreterm infantEnteral nutritionLipidsOmega-3 fatty acidsOmega-6 fatty acidsDocosahexaenoic acidArachidonic acidLong-chain polyunsaturated fatty acidsHuman milk fat is a concentrated source of energy and provides essential and long chain polyunsaturated fatty acids. According to previous experiments, human milk fat is partially lost during continuous enteral nutrition. However, these experiments were done over relatively short infusion times, and a complete profile of the lost fatty acids was never measured. Whether this loss happens considering longer infusion times or if some fatty acids are lost more than others remain unknown. Pooled breast milk was infused through a feeding tube by a peristaltic pump over a period of 30 min and 4, 12 and 24 h at 2 mL/h. Adsorbed fat was extracted from the tubes, and the fatty acid composition was analyzed by gas chromatography-mass spectrometry. Total fat loss (average fatty acid loss) after 24 h was 0.6 ± 0.1%. Total fat loss after 24 h infusion was 0.6 ± 0.1% of the total fat infused, although the highest losses occur in the first 30 min of infusion (13.0 ± 1.6%). Short-medium chain (0.7%, p = 0.15), long chain (0.6%, p = 0.56), saturated (0.7%, p = 0.4), monounsaturated (0.5%, p = 0.15), polyunsaturated fatty (0.7%, p = 0.15), linoleic (0.7%, p = 0.25), and docosahexaenoic acids (0.6%, p = 0.56) were not selectively adsorbed to the tube. However, very long chain fatty (0.9%, p = 0.04), alpha-linolenic (1.6%, p = 0.02) and arachidonic acids (1%, p = 0.02) were selectively adsorbed and, therefore, lost in a greater proportion than other fatty acids. In all cases, the magnitude of the loss was clinically lowTo CSIC Agency (Spain) for support.Peer reviewedMultidisciplinary Digital Publishing InstituteConsejo Superior de Investigaciones Científicas (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2018201820182018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/167936reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/nu10070809Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1679362026-05-22T06:33:51Z
dc.title.none.fl_str_mv Fat loss in continuous enteral feeding of the preterm infant: How much, what and when is it lost?
title Fat loss in continuous enteral feeding of the preterm infant: How much, what and when is it lost?
spellingShingle Fat loss in continuous enteral feeding of the preterm infant: How much, what and when is it lost?
Zozaya, Carlos
Preterm infant
Enteral nutrition
Lipids
Omega-3 fatty acids
Omega-6 fatty acids
Docosahexaenoic acid
Arachidonic acid
Long-chain polyunsaturated fatty acids
title_short Fat loss in continuous enteral feeding of the preterm infant: How much, what and when is it lost?
title_full Fat loss in continuous enteral feeding of the preterm infant: How much, what and when is it lost?
title_fullStr Fat loss in continuous enteral feeding of the preterm infant: How much, what and when is it lost?
title_full_unstemmed Fat loss in continuous enteral feeding of the preterm infant: How much, what and when is it lost?
title_sort Fat loss in continuous enteral feeding of the preterm infant: How much, what and when is it lost?
dc.creator.none.fl_str_mv Zozaya, Carlos
García-Serrano, Alba M.
Fontecha, F. Javier
Redondo-Bravo, Lidia
Sánchez-González, Victoria
Montes, María Teresa
Saenz de Pipaón, Miguel
author Zozaya, Carlos
author_facet Zozaya, Carlos
García-Serrano, Alba M.
Fontecha, F. Javier
Redondo-Bravo, Lidia
Sánchez-González, Victoria
Montes, María Teresa
Saenz de Pipaón, Miguel
author_role author
author2 García-Serrano, Alba M.
Fontecha, F. Javier
Redondo-Bravo, Lidia
Sánchez-González, Victoria
Montes, María Teresa
Saenz de Pipaón, Miguel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Preterm infant
Enteral nutrition
Lipids
Omega-3 fatty acids
Omega-6 fatty acids
Docosahexaenoic acid
Arachidonic acid
Long-chain polyunsaturated fatty acids
topic Preterm infant
Enteral nutrition
Lipids
Omega-3 fatty acids
Omega-6 fatty acids
Docosahexaenoic acid
Arachidonic acid
Long-chain polyunsaturated fatty acids
description Human milk fat is a concentrated source of energy and provides essential and long chain polyunsaturated fatty acids. According to previous experiments, human milk fat is partially lost during continuous enteral nutrition. However, these experiments were done over relatively short infusion times, and a complete profile of the lost fatty acids was never measured. Whether this loss happens considering longer infusion times or if some fatty acids are lost more than others remain unknown. Pooled breast milk was infused through a feeding tube by a peristaltic pump over a period of 30 min and 4, 12 and 24 h at 2 mL/h. Adsorbed fat was extracted from the tubes, and the fatty acid composition was analyzed by gas chromatography-mass spectrometry. Total fat loss (average fatty acid loss) after 24 h was 0.6 ± 0.1%. Total fat loss after 24 h infusion was 0.6 ± 0.1% of the total fat infused, although the highest losses occur in the first 30 min of infusion (13.0 ± 1.6%). Short-medium chain (0.7%, p = 0.15), long chain (0.6%, p = 0.56), saturated (0.7%, p = 0.4), monounsaturated (0.5%, p = 0.15), polyunsaturated fatty (0.7%, p = 0.15), linoleic (0.7%, p = 0.25), and docosahexaenoic acids (0.6%, p = 0.56) were not selectively adsorbed to the tube. However, very long chain fatty (0.9%, p = 0.04), alpha-linolenic (1.6%, p = 0.02) and arachidonic acids (1%, p = 0.02) were selectively adsorbed and, therefore, lost in a greater proportion than other fatty acids. In all cases, the magnitude of the loss was clinically low
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/167936
url http://hdl.handle.net/10261/167936
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/nu10070809
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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