Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging Findings From INCAPS

OBJECTIVES This study sought to establish worldwide and regional diagnostic reference levels (DRLs) and achievable administered activities (AAAs) for single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). BACKGROUND Reference levels serve as radiation dose benchmarks...

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Autores: Hirschfeld, CB, Dondi, M, Pascual, TNB, Mercuri, M, Vitola, J, Karthikeyan, G, Better, N, Mahmarian, JJ, Bouyoucef, SE, Bom, HHS, Lele, V, Magboo, VPC, Alexanderson, E, Allam, AH, Al-Mallah, MH, Flotats, A, Jerome, S, Kaufmann, PA, Luxenburg, O, Underwood, SR, Rehani, MM, Vassileva, J, Paez, D, Einstein, AJ, INCAPS Investigators Grp
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositório:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p1177
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1177
https://hdl.handle.net/11392/2462771
Access Level:Acceso aberto
Palavra-chave:administered activity
diagnostic reference level
radiation dose reduction
SPECT myocardial perfusion imaging
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spelling Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging Findings From INCAPSHirschfeld, CBDondi, MPascual, TNBMercuri, MVitola, JKarthikeyan, GBetter, NMahmarian, JJBouyoucef, SEBom, HHSLele, VMagboo, VPCAlexanderson, EAllam, AHAl-Mallah, MHFlotats, AJerome, SKaufmann, PALuxenburg, OUnderwood, SRRehani, MMVassileva, JPaez, DEinstein, AJINCAPS Investigators Grpadministered activitydiagnostic reference levelradiation dose reductionSPECT myocardial perfusion imagingOBJECTIVES This study sought to establish worldwide and regional diagnostic reference levels (DRLs) and achievable administered activities (AAAs) for single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). BACKGROUND Reference levels serve as radiation dose benchmarks to compare individual laboratories against aggregated data, helping to identify sites in greatest need of dose reduction interventions. DRLs for SPECT MPI have previously been derived from national or regional registries. To date there have been no muttiregional reports of DRLs for SPECT MPI from a single standardized dataset. METHODS Data were submitted voluntarily to the INCAPS (International Atomic Energy Agency Nuclear Cardiology Protocols Study), a cross-sectional, multinational registry of MPI protocols. A total of 7,103 studies were included. DRLs and AAAs were calculated by protocol for each world region and for aggregated worldwide data. RESULTS The aggregated worldwide DRLs for rest-stress or stress-rest studies employing technetium Tc 99m-labeled radiopharmaceuticals were 11.2 mCi (first dose) and 32.0 mCi (second dose) for 1-day protocols, and 23.0 mCi (first dose) and 24.0 mCi (second dose) for multiday protocols. Corresponding AAAs were 10.1 mCi (first dose) and 28.0 mCi (second dose) for 1-day protocols, and 17.8 mCi (first dose) and 18.7 mCi (second dose) for multiday protocols. For stress-only technetium Tc 99m studies, the worldwide DRL and AAA were 18.0 mCi and 12.5 mCi, respectively. Stress-first imaging was used in 26% to 92% of regional studies except in North America where it was used in just 7% of cases. Significant differences in DRLs and AAAs were observed between regions. CONCLUSIONS This study reports reference levels for SPECT MPI for each major world region from one of the largest international registries of clinical MPI studies. Regional DRLs may be useful in establishing or revising guidelines or simply comparing individual laboratory protocols to regional trends. Organizations should continue to focus on establishing standardized reporting methods to improve the validity and comparability of regional DRLs. (C) 2021 by the American College of Cardiology Foundation.ELSEVIER SCIENCE INC2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1177https://hdl.handle.net/11392/2462771JACC-Cardiovascular ImagingISSN: 1936878XISSNe: 18767591reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p11772026-06-14T12:41:47Z
dc.title.none.fl_str_mv Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging Findings From INCAPS
title Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging Findings From INCAPS
spellingShingle Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging Findings From INCAPS
Hirschfeld, CB
administered activity
diagnostic reference level
radiation dose reduction
SPECT myocardial perfusion imaging
title_short Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging Findings From INCAPS
title_full Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging Findings From INCAPS
title_fullStr Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging Findings From INCAPS
title_full_unstemmed Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging Findings From INCAPS
title_sort Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging Findings From INCAPS
dc.creator.none.fl_str_mv Hirschfeld, CB
Dondi, M
Pascual, TNB
Mercuri, M
Vitola, J
Karthikeyan, G
Better, N
Mahmarian, JJ
Bouyoucef, SE
Bom, HHS
Lele, V
Magboo, VPC
Alexanderson, E
Allam, AH
Al-Mallah, MH
Flotats, A
Jerome, S
Kaufmann, PA
Luxenburg, O
Underwood, SR
Rehani, MM
Vassileva, J
Paez, D
Einstein, AJ
INCAPS Investigators Grp
author Hirschfeld, CB
author_facet Hirschfeld, CB
Dondi, M
Pascual, TNB
Mercuri, M
Vitola, J
Karthikeyan, G
Better, N
Mahmarian, JJ
Bouyoucef, SE
Bom, HHS
Lele, V
Magboo, VPC
Alexanderson, E
Allam, AH
Al-Mallah, MH
Flotats, A
Jerome, S
Kaufmann, PA
Luxenburg, O
Underwood, SR
Rehani, MM
Vassileva, J
Paez, D
Einstein, AJ
INCAPS Investigators Grp
author_role author
author2 Dondi, M
Pascual, TNB
Mercuri, M
Vitola, J
Karthikeyan, G
Better, N
Mahmarian, JJ
Bouyoucef, SE
Bom, HHS
Lele, V
Magboo, VPC
Alexanderson, E
Allam, AH
Al-Mallah, MH
Flotats, A
Jerome, S
Kaufmann, PA
Luxenburg, O
Underwood, SR
Rehani, MM
Vassileva, J
Paez, D
Einstein, AJ
INCAPS Investigators Grp
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv administered activity
diagnostic reference level
radiation dose reduction
SPECT myocardial perfusion imaging
topic administered activity
diagnostic reference level
radiation dose reduction
SPECT myocardial perfusion imaging
description OBJECTIVES This study sought to establish worldwide and regional diagnostic reference levels (DRLs) and achievable administered activities (AAAs) for single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). BACKGROUND Reference levels serve as radiation dose benchmarks to compare individual laboratories against aggregated data, helping to identify sites in greatest need of dose reduction interventions. DRLs for SPECT MPI have previously been derived from national or regional registries. To date there have been no muttiregional reports of DRLs for SPECT MPI from a single standardized dataset. METHODS Data were submitted voluntarily to the INCAPS (International Atomic Energy Agency Nuclear Cardiology Protocols Study), a cross-sectional, multinational registry of MPI protocols. A total of 7,103 studies were included. DRLs and AAAs were calculated by protocol for each world region and for aggregated worldwide data. RESULTS The aggregated worldwide DRLs for rest-stress or stress-rest studies employing technetium Tc 99m-labeled radiopharmaceuticals were 11.2 mCi (first dose) and 32.0 mCi (second dose) for 1-day protocols, and 23.0 mCi (first dose) and 24.0 mCi (second dose) for multiday protocols. Corresponding AAAs were 10.1 mCi (first dose) and 28.0 mCi (second dose) for 1-day protocols, and 17.8 mCi (first dose) and 18.7 mCi (second dose) for multiday protocols. For stress-only technetium Tc 99m studies, the worldwide DRL and AAA were 18.0 mCi and 12.5 mCi, respectively. Stress-first imaging was used in 26% to 92% of regional studies except in North America where it was used in just 7% of cases. Significant differences in DRLs and AAAs were observed between regions. CONCLUSIONS This study reports reference levels for SPECT MPI for each major world region from one of the largest international registries of clinical MPI studies. Regional DRLs may be useful in establishing or revising guidelines or simply comparing individual laboratory protocols to regional trends. Organizations should continue to focus on establishing standardized reporting methods to improve the validity and comparability of regional DRLs. (C) 2021 by the American College of Cardiology Foundation.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1177
https://hdl.handle.net/11392/2462771
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1177
https://hdl.handle.net/11392/2462771
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCIENCE INC
publisher.none.fl_str_mv ELSEVIER SCIENCE INC
dc.source.none.fl_str_mv JACC-Cardiovascular Imaging
ISSN: 1936878X
ISSNe: 18767591
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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