Pathogenic Leptospira species in rodents from Corsica (France)

Leptospirosis is a worldwide emerging zoonotic disease caused by Leptospira species, that in some patients develop severe forms with high mortality. In France, Corsica is the area where the highest incidences have been reported. The present study was focused on the analysis of pathogenic Leptospira...

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Detalhes bibliográficos
Autores: Izquierdo-Rodríguez, Elena, Fernández-Álvarez, Ángela, Martín-Carrillo, Natalia, Marchand, Bernard, Feliu José, Carlos, Miquel Colomé, Jordi, Foronda, Pilar, Quilichini, Yann
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/166988
Acesso em linha:https://hdl.handle.net/2445/166988
Access Level:acceso abierto
Palavra-chave:Leptospirosi
Rosegadors
Filogènia
Salut pública
Contaminació de l'aigua
Bacteris
Còrsega (França)
Rodents
Phylogeny
Public health
Water pollution
Bacteria
Corsica (France)
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oai_identifier_str oai:recercat.cat:2445/166988
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spelling Pathogenic Leptospira species in rodents from Corsica (France)Izquierdo-Rodríguez, ElenaFernández-Álvarez, ÁngelaMartín-Carrillo, NataliaMarchand, BernardFeliu José, CarlosMiquel Colomé, JordiForonda, PilarQuilichini, YannLeptospirosiRosegadorsFilogèniaSalut públicaContaminació de l'aiguaBacterisCòrsega (França)LeptospirosiRodentsPhylogenyPublic healthWater pollutionBacteriaCorsica (France)Leptospirosis is a worldwide emerging zoonotic disease caused by Leptospira species, that in some patients develop severe forms with high mortality. In France, Corsica is the area where the highest incidences have been reported. The present study was focused on the analysis of pathogenic Leptospira species in rodents of Corsica, as these micromammals are the main natural reservoirs of the bacteria, in order to identify the circulating species and to locate possible risk focuses of transmission, as no previous study on the presence of Leptospira species has been carried out in the island. Rattus rattus, Rattus norvegicus, Apodemus sylvaticus and Mus musculus domesticus were captured in the proximity of water sources along Corsica, the detection of pathogenic Leptospira species was carried out by amplification of the LipL32 gene. The bacteria were found in all the rodent species analyzed and widely. The general prevalence was 10.4%, reaching the maximum value in Bastia (45%). Leptospira interrogans and Leptospira borgpetersenii were identified by phylogenetic analysis, but also two sequences which corresponded to an unnamed Leptospira species, only previously found in rodents of New Caledonia. The high incidence of human leptospirosis in Corsica could be partially explained by the wide distribution of pathogenic Leptospira species identified in this study. Also, the presence of an unknown pathogenic species of Leptospira in an area with high prevalence, may be involved in the higher incidence of Leptospirosis in this island, however, the zoonotic capacity of this species remains unknown. The results obtained are interesting for public health since all positive samples were found near water sources and one of the routes of transmission of leptospirosis is contact with contaminated water. This information could help the competent entities to take preventive measures, reducing the incidence of human leptospirosis in Corsica.Public Library of Science (PLoS)2020202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/166988Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0233776PLoS One, 2020, vol. 15, num. 6, p. e0233776https://doi.org/10.1371/journal.pone.0233776cc-by (c) Izquierdo-Rodríguez, Elena et al., 2020http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1669882026-05-29T05:05:01Z
dc.title.none.fl_str_mv Pathogenic Leptospira species in rodents from Corsica (France)
title Pathogenic Leptospira species in rodents from Corsica (France)
spellingShingle Pathogenic Leptospira species in rodents from Corsica (France)
Izquierdo-Rodríguez, Elena
Leptospirosi
Rosegadors
Filogènia
Salut pública
Contaminació de l'aigua
Bacteris
Còrsega (França)
Leptospirosi
Rodents
Phylogeny
Public health
Water pollution
Bacteria
Corsica (France)
title_short Pathogenic Leptospira species in rodents from Corsica (France)
title_full Pathogenic Leptospira species in rodents from Corsica (France)
title_fullStr Pathogenic Leptospira species in rodents from Corsica (France)
title_full_unstemmed Pathogenic Leptospira species in rodents from Corsica (France)
title_sort Pathogenic Leptospira species in rodents from Corsica (France)
dc.creator.none.fl_str_mv Izquierdo-Rodríguez, Elena
Fernández-Álvarez, Ángela
Martín-Carrillo, Natalia
Marchand, Bernard
Feliu José, Carlos
Miquel Colomé, Jordi
Foronda, Pilar
Quilichini, Yann
author Izquierdo-Rodríguez, Elena
author_facet Izquierdo-Rodríguez, Elena
Fernández-Álvarez, Ángela
Martín-Carrillo, Natalia
Marchand, Bernard
Feliu José, Carlos
Miquel Colomé, Jordi
Foronda, Pilar
Quilichini, Yann
author_role author
author2 Fernández-Álvarez, Ángela
Martín-Carrillo, Natalia
Marchand, Bernard
Feliu José, Carlos
Miquel Colomé, Jordi
Foronda, Pilar
Quilichini, Yann
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Leptospirosi
Rosegadors
Filogènia
Salut pública
Contaminació de l'aigua
Bacteris
Còrsega (França)
Leptospirosi
Rodents
Phylogeny
Public health
Water pollution
Bacteria
Corsica (France)
topic Leptospirosi
Rosegadors
Filogènia
Salut pública
Contaminació de l'aigua
Bacteris
Còrsega (França)
Leptospirosi
Rodents
Phylogeny
Public health
Water pollution
Bacteria
Corsica (France)
description Leptospirosis is a worldwide emerging zoonotic disease caused by Leptospira species, that in some patients develop severe forms with high mortality. In France, Corsica is the area where the highest incidences have been reported. The present study was focused on the analysis of pathogenic Leptospira species in rodents of Corsica, as these micromammals are the main natural reservoirs of the bacteria, in order to identify the circulating species and to locate possible risk focuses of transmission, as no previous study on the presence of Leptospira species has been carried out in the island. Rattus rattus, Rattus norvegicus, Apodemus sylvaticus and Mus musculus domesticus were captured in the proximity of water sources along Corsica, the detection of pathogenic Leptospira species was carried out by amplification of the LipL32 gene. The bacteria were found in all the rodent species analyzed and widely. The general prevalence was 10.4%, reaching the maximum value in Bastia (45%). Leptospira interrogans and Leptospira borgpetersenii were identified by phylogenetic analysis, but also two sequences which corresponded to an unnamed Leptospira species, only previously found in rodents of New Caledonia. The high incidence of human leptospirosis in Corsica could be partially explained by the wide distribution of pathogenic Leptospira species identified in this study. Also, the presence of an unknown pathogenic species of Leptospira in an area with high prevalence, may be involved in the higher incidence of Leptospirosis in this island, however, the zoonotic capacity of this species remains unknown. The results obtained are interesting for public health since all positive samples were found near water sources and one of the routes of transmission of leptospirosis is contact with contaminated water. This information could help the competent entities to take preventive measures, reducing the incidence of human leptospirosis in Corsica.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/166988
url https://hdl.handle.net/2445/166988
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0233776
PLoS One, 2020, vol. 15, num. 6, p. e0233776
https://doi.org/10.1371/journal.pone.0233776
dc.rights.none.fl_str_mv cc-by (c) Izquierdo-Rodríguez, Elena et al., 2020
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Izquierdo-Rodríguez, Elena et al., 2020
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,228081

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