Kinetic Modelling of the Coproduction Process of Fumaric and Malic Acids by Rhizopus arrhizus NRRL 1526

The production of organic acids by biotechnological processes has experienced a notable impulse with the advent of first and second generation biorefineries and the need of searching for renewable and sustainable feedstock, such as biomass. Fumaric acid is a promising biomonomer for polyamide produc...

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Authors: Martín Domínguez, Víctor, Bouzas Santiso, Laura, Martínez Peinado, Nieves, Santos Mazorra, Victoria Eugenia, Ladero Galán, Miguel
Format: article
Publication Date:2020
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/8290
Online Access:https://hdl.handle.net/20.500.14352/8290
Access Level:Open access
Keyword:biorefinery
fermentation
fumaric acid
malic acid
filamentous fungi
kinetic modelling
Ingeniería química
Materiales
3303 Ingeniería y Tecnología Químicas
3312 Tecnología de Materiales
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oai_identifier_str oai:docta.ucm.es:20.500.14352/8290
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spelling Kinetic Modelling of the Coproduction Process of Fumaric and Malic Acids by Rhizopus arrhizus NRRL 1526Martín Domínguez, VíctorBouzas Santiso, LauraMartínez Peinado, NievesSantos Mazorra, Victoria EugeniaLadero Galán, Miguelbiorefineryfermentationfumaric acidmalic acidfilamentous fungikinetic modellingIngeniería químicaMateriales3303 Ingeniería y Tecnología Químicas3312 Tecnología de MaterialesThe production of organic acids by biotechnological processes has experienced a notable impulse with the advent of first and second generation biorefineries and the need of searching for renewable and sustainable feedstock, such as biomass. Fumaric acid is a promising biomonomer for polyamide production and a well-known acidulant and preservative in food and feed industries. Malic acid is a well-known food acidulant with a high market share. The biotechnological Fumaric and Malic acid production via fungi of the Rhizopus genus is being explored nowadays as a process for the valorization of food and food-related waste to obtain food ingredients and key platform chemicals of the so-called biochemical biorefinery. In this work, a preliminary study is performed to find reproducible conditions for the production of the acids by Rhizopus arrhizus NRRL 1526 by controlling fungi morphology and inoculum conditions. Afterwards, several production runs are performed to obtain biomass, glucose, and acid concentration data at different processing time values. Finally, an unstructured, unsegregated model including a logistic-type equation for biomass and potential-type equations for the substrate and the products is fitted to experimental data. We find that the production of the organic acids is mainly non-associated with fungal growth.MDPIUniversidad Complutense de Madrid20202020-02-0520202020-02-05journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/8290reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/82902026-06-02T12:44:21Z
dc.title.none.fl_str_mv Kinetic Modelling of the Coproduction Process of Fumaric and Malic Acids by Rhizopus arrhizus NRRL 1526
title Kinetic Modelling of the Coproduction Process of Fumaric and Malic Acids by Rhizopus arrhizus NRRL 1526
spellingShingle Kinetic Modelling of the Coproduction Process of Fumaric and Malic Acids by Rhizopus arrhizus NRRL 1526
Martín Domínguez, Víctor
biorefinery
fermentation
fumaric acid
malic acid
filamentous fungi
kinetic modelling
Ingeniería química
Materiales
3303 Ingeniería y Tecnología Químicas
3312 Tecnología de Materiales
title_short Kinetic Modelling of the Coproduction Process of Fumaric and Malic Acids by Rhizopus arrhizus NRRL 1526
title_full Kinetic Modelling of the Coproduction Process of Fumaric and Malic Acids by Rhizopus arrhizus NRRL 1526
title_fullStr Kinetic Modelling of the Coproduction Process of Fumaric and Malic Acids by Rhizopus arrhizus NRRL 1526
title_full_unstemmed Kinetic Modelling of the Coproduction Process of Fumaric and Malic Acids by Rhizopus arrhizus NRRL 1526
title_sort Kinetic Modelling of the Coproduction Process of Fumaric and Malic Acids by Rhizopus arrhizus NRRL 1526
dc.creator.none.fl_str_mv Martín Domínguez, Víctor
Bouzas Santiso, Laura
Martínez Peinado, Nieves
Santos Mazorra, Victoria Eugenia
Ladero Galán, Miguel
author Martín Domínguez, Víctor
author_facet Martín Domínguez, Víctor
Bouzas Santiso, Laura
Martínez Peinado, Nieves
Santos Mazorra, Victoria Eugenia
Ladero Galán, Miguel
author_role author
author2 Bouzas Santiso, Laura
Martínez Peinado, Nieves
Santos Mazorra, Victoria Eugenia
Ladero Galán, Miguel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv biorefinery
fermentation
fumaric acid
malic acid
filamentous fungi
kinetic modelling
Ingeniería química
Materiales
3303 Ingeniería y Tecnología Químicas
3312 Tecnología de Materiales
topic biorefinery
fermentation
fumaric acid
malic acid
filamentous fungi
kinetic modelling
Ingeniería química
Materiales
3303 Ingeniería y Tecnología Químicas
3312 Tecnología de Materiales
description The production of organic acids by biotechnological processes has experienced a notable impulse with the advent of first and second generation biorefineries and the need of searching for renewable and sustainable feedstock, such as biomass. Fumaric acid is a promising biomonomer for polyamide production and a well-known acidulant and preservative in food and feed industries. Malic acid is a well-known food acidulant with a high market share. The biotechnological Fumaric and Malic acid production via fungi of the Rhizopus genus is being explored nowadays as a process for the valorization of food and food-related waste to obtain food ingredients and key platform chemicals of the so-called biochemical biorefinery. In this work, a preliminary study is performed to find reproducible conditions for the production of the acids by Rhizopus arrhizus NRRL 1526 by controlling fungi morphology and inoculum conditions. Afterwards, several production runs are performed to obtain biomass, glucose, and acid concentration data at different processing time values. Finally, an unstructured, unsegregated model including a logistic-type equation for biomass and potential-type equations for the substrate and the products is fitted to experimental data. We find that the production of the organic acids is mainly non-associated with fungal growth.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-02-05
2020
2020-02-05
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/8290
url https://hdl.handle.net/20.500.14352/8290
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869418162810781696
score 15.228081

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