YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies
Background: The innate immune system is known to be involved early in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. The inflammatory response in the central nervous system can be measured postmortem or through a series of inflammatory mediator surrogates. Y...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| Repositorio: | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| OAI Identifier: | oai:iibsantpau.fundanetsuite.com:p10422 |
| Acceso en línea: | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=10422 http://ddd.uab.cat/record/186266 |
| Access Level: | acceso abierto |
| Palabra clave: | chitinase 3 like protein 1 glial fibrillary acidic protein CHI3L1 protein, human Alzheimer disease Article astrocyte cell subpopulation clinical article controlled study corticobasal degeneration cytoplasm disease association frontal cortex human human cell human tissue immunoreactivity Pick presenile dementia progressive supranuclear palsy protein aggregation protein expression protein localization tauopathy biosynthesis brain enzymology gene expression regulation genetics pathology Alzheimer Disease Astrocytes Brain Chitinase-3-Like Protein 1 Gene Expression Regulation, Enzymologic Humans Tauopathies |
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YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathiesQuerol-Vilaseca M.Colom-Cadena M.Pegueroles J.San Martín-Paniello C.Clarimon J.Belbin O.Fortea J.Lleó A.chitinase 3 like protein 1glial fibrillary acidic proteinCHI3L1 protein, humanchitinase 3 like protein 1Alzheimer diseaseArticleastrocytecell subpopulationclinical articlecontrolled studycorticobasal degenerationcytoplasmdisease associationfrontal cortexhumanhuman cellhuman tissueimmunoreactivityPick presenile dementiaprogressive supranuclear palsyprotein aggregationprotein expressionprotein localizationtauopathyAlzheimer diseaseastrocytebiosynthesisbrainenzymologygene expression regulationgeneticspathologytauopathyAlzheimer DiseaseAstrocytesBrainChitinase-3-Like Protein 1Gene Expression Regulation, EnzymologicHumansTauopathiesBackground: The innate immune system is known to be involved early in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. The inflammatory response in the central nervous system can be measured postmortem or through a series of inflammatory mediator surrogates. YKL-40 (also named Chitinase-3-like I) has been frequently investigated in body fluids as a surrogate marker of neuroinflammation in AD and other neurological disorders. However, the expression pattern of YKL-40 in the human brain with neurodegenerative pathology remains poorly investigated. Our aim was to study the cellular expression pattern of YKL-40 in the brain of patients with clinical and neuropathological criteria for AD (n = 11); three non-AD tauopathies: Pick's disease (PiD; n = 8), corticobasal degeneration (CBD; n = 8) and progressive supranuclear palsy (PSP; n = 9) and a group of neurologically healthy controls (n = 6). Methods: Semiquantitative neuropathological evaluation and quantitative confocal triple immunofluorescence studies were performed. An in-house algorithm was used to detect and quantify pathology burden of random regions of interest on a full tissue-section scan. Kruskal-Wallis and Dunn's multiple comparison tests were performed for colocalization and quantification analyses. Results: We found that brain YKL-40 immunoreactivity was observed in a subset of astrocytes in all four diseases and in controls. There was a strong colocalization between YKL-40 and the astroglial marker GFAP but not with neuronal nor microglial markers. Intriguingly, YKL-40-positive astrocytes were tau-negative in PSP, CBD and PiD. The number of YKL-40-positive astrocytes was increased in tauopathies compared with that in controls. A positive correlation was found between YKL-40 and tau immunoreactivities. Conclusions: This study confirms that YKL-40 is expressed by a subset of astrocytes in AD and other tauopathies. YKL-40 expression is elevated in several neurodegenerative conditions and correlates with tau pathology. © 2017 The Author(s).BMC2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=10422http://ddd.uab.cat/record/186266Journal of NeuroinflammationISSN: 17422094reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p104222026-06-14T12:41:47Z |
| dc.title.none.fl_str_mv |
YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies |
| title |
YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies |
| spellingShingle |
YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies Querol-Vilaseca M. chitinase 3 like protein 1 glial fibrillary acidic protein CHI3L1 protein, human chitinase 3 like protein 1 Alzheimer disease Article astrocyte cell subpopulation clinical article controlled study corticobasal degeneration cytoplasm disease association frontal cortex human human cell human tissue immunoreactivity Pick presenile dementia progressive supranuclear palsy protein aggregation protein expression protein localization tauopathy Alzheimer disease astrocyte biosynthesis brain enzymology gene expression regulation genetics pathology tauopathy Alzheimer Disease Astrocytes Brain Chitinase-3-Like Protein 1 Gene Expression Regulation, Enzymologic Humans Tauopathies |
| title_short |
YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies |
| title_full |
YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies |
| title_fullStr |
YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies |
| title_full_unstemmed |
YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies |
| title_sort |
YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies |
| dc.creator.none.fl_str_mv |
Querol-Vilaseca M. Colom-Cadena M. Pegueroles J. San Martín-Paniello C. Clarimon J. Belbin O. Fortea J. Lleó A. |
| author |
Querol-Vilaseca M. |
| author_facet |
Querol-Vilaseca M. Colom-Cadena M. Pegueroles J. San Martín-Paniello C. Clarimon J. Belbin O. Fortea J. Lleó A. |
| author_role |
author |
| author2 |
Colom-Cadena M. Pegueroles J. San Martín-Paniello C. Clarimon J. Belbin O. Fortea J. Lleó A. |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
chitinase 3 like protein 1 glial fibrillary acidic protein CHI3L1 protein, human chitinase 3 like protein 1 Alzheimer disease Article astrocyte cell subpopulation clinical article controlled study corticobasal degeneration cytoplasm disease association frontal cortex human human cell human tissue immunoreactivity Pick presenile dementia progressive supranuclear palsy protein aggregation protein expression protein localization tauopathy Alzheimer disease astrocyte biosynthesis brain enzymology gene expression regulation genetics pathology tauopathy Alzheimer Disease Astrocytes Brain Chitinase-3-Like Protein 1 Gene Expression Regulation, Enzymologic Humans Tauopathies |
| topic |
chitinase 3 like protein 1 glial fibrillary acidic protein CHI3L1 protein, human chitinase 3 like protein 1 Alzheimer disease Article astrocyte cell subpopulation clinical article controlled study corticobasal degeneration cytoplasm disease association frontal cortex human human cell human tissue immunoreactivity Pick presenile dementia progressive supranuclear palsy protein aggregation protein expression protein localization tauopathy Alzheimer disease astrocyte biosynthesis brain enzymology gene expression regulation genetics pathology tauopathy Alzheimer Disease Astrocytes Brain Chitinase-3-Like Protein 1 Gene Expression Regulation, Enzymologic Humans Tauopathies |
| description |
Background: The innate immune system is known to be involved early in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. The inflammatory response in the central nervous system can be measured postmortem or through a series of inflammatory mediator surrogates. YKL-40 (also named Chitinase-3-like I) has been frequently investigated in body fluids as a surrogate marker of neuroinflammation in AD and other neurological disorders. However, the expression pattern of YKL-40 in the human brain with neurodegenerative pathology remains poorly investigated. Our aim was to study the cellular expression pattern of YKL-40 in the brain of patients with clinical and neuropathological criteria for AD (n = 11); three non-AD tauopathies: Pick's disease (PiD; n = 8), corticobasal degeneration (CBD; n = 8) and progressive supranuclear palsy (PSP; n = 9) and a group of neurologically healthy controls (n = 6). Methods: Semiquantitative neuropathological evaluation and quantitative confocal triple immunofluorescence studies were performed. An in-house algorithm was used to detect and quantify pathology burden of random regions of interest on a full tissue-section scan. Kruskal-Wallis and Dunn's multiple comparison tests were performed for colocalization and quantification analyses. Results: We found that brain YKL-40 immunoreactivity was observed in a subset of astrocytes in all four diseases and in controls. There was a strong colocalization between YKL-40 and the astroglial marker GFAP but not with neuronal nor microglial markers. Intriguingly, YKL-40-positive astrocytes were tau-negative in PSP, CBD and PiD. The number of YKL-40-positive astrocytes was increased in tauopathies compared with that in controls. A positive correlation was found between YKL-40 and tau immunoreactivities. Conclusions: This study confirms that YKL-40 is expressed by a subset of astrocytes in AD and other tauopathies. YKL-40 expression is elevated in several neurodegenerative conditions and correlates with tau pathology. © 2017 The Author(s). |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=10422 http://ddd.uab.cat/record/186266 |
| url |
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=10422 http://ddd.uab.cat/record/186266 |
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Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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BMC |
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BMC |
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Journal of Neuroinflammation ISSN: 17422094 reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
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Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
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r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
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