Prediabetes Is Associated with Increased Prevalence of Sleep-Disordered Breathing
Type 2 diabetes leads to severe nocturnal hypoxemia, with an increase in apnea events and daytime sleepiness. Hence, we assessed sleep breathing parameters in the prediabetes stage. A cross-sectional study conducted on 966 middle-aged subjects without known pulmonary disease (311 patients with predi...
| Autores: | , , , , , , , , , , , , , , , , , , |
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| Formato: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:258941 |
| Acesso em linha: | https://ddd.uab.cat/record/258941 https://dx.doi.org/urn:doi:10.3390/jcm11051413 |
| Access Level: | acceso abierto |
| Palavra-chave: | Apnea Glycated hemoglobin Hypopnea Prediabetes Obstructive sleep apnea |
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Prediabetes Is Associated with Increased Prevalence of Sleep-Disordered BreathingSánchez, Enric|||0000-0001-7345-1601Sapiña-Beltrán, Esther|||0000-0002-0053-266XGavaldà, RicardBarbé, Ferran|||0000-0002-2340-8928Torres, Gerard|||0000-0002-1417-7320Sauret, AriadnaDalmases, MireiaLópez-Cano, Carolina|||0000-0001-7458-5871Gutiérrez-Carrasquilla, Liliana|||0000-0001-7809-3903Bermúdez-López, Marcelino|||0000-0002-3188-4158Fernández, Elvira|||0000-0001-5236-1762Purroy, Francisco|||0000-0002-1808-5968Castro-Boqué, Eva|||0000-0002-1013-0007Farràs-Sallés, Cristina|||0000-0001-5956-4116Pamplona, Reinald|||0000-0003-4337-6107Mauricio, Didac|||0000-0002-2868-0250Hernández, Cristina|||0000-0002-3109-1721Simó Canonge, Rafael|||0000-0003-0475-3096Lecube, Albert|||0000-0001-9684-0183ApneaGlycated hemoglobinHypopneaPrediabetesObstructive sleep apneaType 2 diabetes leads to severe nocturnal hypoxemia, with an increase in apnea events and daytime sleepiness. Hence, we assessed sleep breathing parameters in the prediabetes stage. A cross-sectional study conducted on 966 middle-aged subjects without known pulmonary disease (311 patients with prediabetes and 655 controls with normal glucose metabolism) was conducted. Prediabetes was defined by glycated hemoglobin (HbA1c), and a nonattended overnight home sleep study was performed. Participants with prediabetes (n = 311) displayed a higher apnea-hypopnea index (AHI: 12.7 (6.1;24.3) vs. 9.5 (4.2;19.6) events/h, p < 0.001) and hypopnea index (HI: 8.4 (4.0;14.9) vs. 6.0 (2.7;12.6) events/h, p < 0.001) than controls, without differences in the apnea index. Altogether, the prevalence of obstructive sleep apnea was higher in subjects with prediabetes than in controls (78.1 vs. 69.9%, p = 0.007). Additionally, subjects with prediabetes presented impaired measurements of the median and minimum nocturnal oxygen saturation, the percentage of time spent with oxygen saturations below 90%, and the 4% oxygen desaturation index in comparison with individuals without prediabetes (p < 0.001 for all). After adjusting for age, sex, and the presence of obesity, HbA1c correlated with the HI in the entire population (r = 0.141, p < 0.001), and the presence of prediabetes was independently associated with the AHI (B = 2.20 (0.10 to 4.31), p = 0.040) as well as the HI (B = 1.87 (0.61 to 3.14), p = 0.004) in the multiple linear regression model. We conclude that prediabetes is an independent risk factor for an increased AHI after adjusting for age, sex, and obesity. The enhanced AHI is mainly associated with increments in the hypopnea events. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/258941https://dx.doi.org/urn:doi:10.3390/jcm11051413reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-696Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 SLT002160025Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI12/00803Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/00260Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00964open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2589412026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Prediabetes Is Associated with Increased Prevalence of Sleep-Disordered Breathing |
| title |
Prediabetes Is Associated with Increased Prevalence of Sleep-Disordered Breathing |
| spellingShingle |
Prediabetes Is Associated with Increased Prevalence of Sleep-Disordered Breathing Sánchez, Enric|||0000-0001-7345-1601 Apnea Glycated hemoglobin Hypopnea Prediabetes Obstructive sleep apnea |
| title_short |
Prediabetes Is Associated with Increased Prevalence of Sleep-Disordered Breathing |
| title_full |
Prediabetes Is Associated with Increased Prevalence of Sleep-Disordered Breathing |
| title_fullStr |
Prediabetes Is Associated with Increased Prevalence of Sleep-Disordered Breathing |
| title_full_unstemmed |
Prediabetes Is Associated with Increased Prevalence of Sleep-Disordered Breathing |
| title_sort |
Prediabetes Is Associated with Increased Prevalence of Sleep-Disordered Breathing |
| dc.creator.none.fl_str_mv |
Sánchez, Enric|||0000-0001-7345-1601 Sapiña-Beltrán, Esther|||0000-0002-0053-266X Gavaldà, Ricard Barbé, Ferran|||0000-0002-2340-8928 Torres, Gerard|||0000-0002-1417-7320 Sauret, Ariadna Dalmases, Mireia López-Cano, Carolina|||0000-0001-7458-5871 Gutiérrez-Carrasquilla, Liliana|||0000-0001-7809-3903 Bermúdez-López, Marcelino|||0000-0002-3188-4158 Fernández, Elvira|||0000-0001-5236-1762 Purroy, Francisco|||0000-0002-1808-5968 Castro-Boqué, Eva|||0000-0002-1013-0007 Farràs-Sallés, Cristina|||0000-0001-5956-4116 Pamplona, Reinald|||0000-0003-4337-6107 Mauricio, Didac|||0000-0002-2868-0250 Hernández, Cristina|||0000-0002-3109-1721 Simó Canonge, Rafael|||0000-0003-0475-3096 Lecube, Albert|||0000-0001-9684-0183 |
| author |
Sánchez, Enric|||0000-0001-7345-1601 |
| author_facet |
Sánchez, Enric|||0000-0001-7345-1601 Sapiña-Beltrán, Esther|||0000-0002-0053-266X Gavaldà, Ricard Barbé, Ferran|||0000-0002-2340-8928 Torres, Gerard|||0000-0002-1417-7320 Sauret, Ariadna Dalmases, Mireia López-Cano, Carolina|||0000-0001-7458-5871 Gutiérrez-Carrasquilla, Liliana|||0000-0001-7809-3903 Bermúdez-López, Marcelino|||0000-0002-3188-4158 Fernández, Elvira|||0000-0001-5236-1762 Purroy, Francisco|||0000-0002-1808-5968 Castro-Boqué, Eva|||0000-0002-1013-0007 Farràs-Sallés, Cristina|||0000-0001-5956-4116 Pamplona, Reinald|||0000-0003-4337-6107 Mauricio, Didac|||0000-0002-2868-0250 Hernández, Cristina|||0000-0002-3109-1721 Simó Canonge, Rafael|||0000-0003-0475-3096 Lecube, Albert|||0000-0001-9684-0183 |
| author_role |
author |
| author2 |
Sapiña-Beltrán, Esther|||0000-0002-0053-266X Gavaldà, Ricard Barbé, Ferran|||0000-0002-2340-8928 Torres, Gerard|||0000-0002-1417-7320 Sauret, Ariadna Dalmases, Mireia López-Cano, Carolina|||0000-0001-7458-5871 Gutiérrez-Carrasquilla, Liliana|||0000-0001-7809-3903 Bermúdez-López, Marcelino|||0000-0002-3188-4158 Fernández, Elvira|||0000-0001-5236-1762 Purroy, Francisco|||0000-0002-1808-5968 Castro-Boqué, Eva|||0000-0002-1013-0007 Farràs-Sallés, Cristina|||0000-0001-5956-4116 Pamplona, Reinald|||0000-0003-4337-6107 Mauricio, Didac|||0000-0002-2868-0250 Hernández, Cristina|||0000-0002-3109-1721 Simó Canonge, Rafael|||0000-0003-0475-3096 Lecube, Albert|||0000-0001-9684-0183 |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Apnea Glycated hemoglobin Hypopnea Prediabetes Obstructive sleep apnea |
| topic |
Apnea Glycated hemoglobin Hypopnea Prediabetes Obstructive sleep apnea |
| description |
Type 2 diabetes leads to severe nocturnal hypoxemia, with an increase in apnea events and daytime sleepiness. Hence, we assessed sleep breathing parameters in the prediabetes stage. A cross-sectional study conducted on 966 middle-aged subjects without known pulmonary disease (311 patients with prediabetes and 655 controls with normal glucose metabolism) was conducted. Prediabetes was defined by glycated hemoglobin (HbA1c), and a nonattended overnight home sleep study was performed. Participants with prediabetes (n = 311) displayed a higher apnea-hypopnea index (AHI: 12.7 (6.1;24.3) vs. 9.5 (4.2;19.6) events/h, p < 0.001) and hypopnea index (HI: 8.4 (4.0;14.9) vs. 6.0 (2.7;12.6) events/h, p < 0.001) than controls, without differences in the apnea index. Altogether, the prevalence of obstructive sleep apnea was higher in subjects with prediabetes than in controls (78.1 vs. 69.9%, p = 0.007). Additionally, subjects with prediabetes presented impaired measurements of the median and minimum nocturnal oxygen saturation, the percentage of time spent with oxygen saturations below 90%, and the 4% oxygen desaturation index in comparison with individuals without prediabetes (p < 0.001 for all). After adjusting for age, sex, and the presence of obesity, HbA1c correlated with the HI in the entire population (r = 0.141, p < 0.001), and the presence of prediabetes was independently associated with the AHI (B = 2.20 (0.10 to 4.31), p = 0.040) as well as the HI (B = 1.87 (0.61 to 3.14), p = 0.004) in the multiple linear regression model. We conclude that prediabetes is an independent risk factor for an increased AHI after adjusting for age, sex, and obesity. The enhanced AHI is mainly associated with increments in the hypopnea events. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/258941 https://dx.doi.org/urn:doi:10.3390/jcm11051413 |
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https://ddd.uab.cat/record/258941 https://dx.doi.org/urn:doi:10.3390/jcm11051413 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
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eng |
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Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-696 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 SLT002160025 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI12/00803 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/00260 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00964 |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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