Design and validation of the 1-week memory battery for assessing episodic memory and accelerated long-term forgetting in cognitively unimpaired subjects

Subtle decline in memory is thought to arise in the preclinical phase of Alzheimer's disease (AD). However, detecting these initial cognitive difficulties cross-sectionally has been challenging, and the exact nature of the decline is still debated. Accelerated long-term forgetting (ALF) has bee...

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Authors: Rami González, Lorena, León, María, Valech, Natalia, Coll Padrós, Nina, Bosch, Beatriz, Olives, Jaume, Salinero, Ana, Pérez Millan, Agnès, Molinuevo, José Luis, Sánchez Valle, Raquel, Tort Merino, Adrià
Format: article
Status:Versión aceptada para publicación
Publication Date:2023
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/206200
Online Access:https://hdl.handle.net/2445/206200
Access Level:Open access
Keyword:Malaltia d'Alzheimer
Funcions executives (Neuropsicologia)
Alzheimer's disease
Executive functions (Neuropsychology)
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spelling Design and validation of the 1-week memory battery for assessing episodic memory and accelerated long-term forgetting in cognitively unimpaired subjectsRami González, LorenaLeón, MaríaValech, NataliaColl Padrós, NinaBosch, BeatrizOlives, JaumeSalinero, AnaPérez Millan, AgnèsMolinuevo, José LuisSánchez Valle, RaquelTort Merino, AdriàMalaltia d'AlzheimerFuncions executives (Neuropsicologia)Alzheimer's diseaseExecutive functions (Neuropsychology)Subtle decline in memory is thought to arise in the preclinical phase of Alzheimer's disease (AD). However, detecting these initial cognitive difficulties cross-sectionally has been challenging, and the exact nature of the decline is still debated. Accelerated long-term forgetting (ALF) has been recently suggested as one of the earliest and most sensitive indicators of memory dysfunction in subjects at risk of developing AD. The objective of this study was to design and validate the 1-week memory battery (1WMB) for assessing episodic memory and ALF in cognitively unimpaired individuals.The 1WMB is unique in that it assesses multimodal memory and measures recall at both short delay (20 min) and at long term (1 week). Forty-five cognitively unimpaired subjects were assessed with 1WMB and standardized neuropsychological tests. Subjective cognitive decline (SCD), levels of anxiety and depression, and cognitive reserve were also measured.The tests of 1WMB showed a high internal consistency, and concurrent validity was observed with standard tests of episodic memory and executive functions. The analysis revealed a greater loss of information at 1 week compared to short-term forgetting (20 min). Performance in the 1WMB was affected by age and educational level, but was not associated with levels of anxiety and depression. Unlike standard tests, performance in the 1WMB correlated with measures of SCD.Our findings indicate that the 1WMB has good psychometric properties, and future studies are needed to explore its potential usefulness to assess cognitively unimpaired subjects at increased risk of developing AD. (PsycInfo Database Record (c) 2023 APA, all rights reserved).2024202420232024info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion41 p.application/pdfhttps://hdl.handle.net/2445/206200Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1037/neu0000879Neuropsychology, 2023, vol. 37, num. 6, p. 683-697https://doi.org/10.1037/neu0000879(c) Neuropsychology, 2023info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2062002026-05-29T05:05:01Z
dc.title.none.fl_str_mv Design and validation of the 1-week memory battery for assessing episodic memory and accelerated long-term forgetting in cognitively unimpaired subjects
title Design and validation of the 1-week memory battery for assessing episodic memory and accelerated long-term forgetting in cognitively unimpaired subjects
spellingShingle Design and validation of the 1-week memory battery for assessing episodic memory and accelerated long-term forgetting in cognitively unimpaired subjects
Rami González, Lorena
Malaltia d'Alzheimer
Funcions executives (Neuropsicologia)
Alzheimer's disease
Executive functions (Neuropsychology)
title_short Design and validation of the 1-week memory battery for assessing episodic memory and accelerated long-term forgetting in cognitively unimpaired subjects
title_full Design and validation of the 1-week memory battery for assessing episodic memory and accelerated long-term forgetting in cognitively unimpaired subjects
title_fullStr Design and validation of the 1-week memory battery for assessing episodic memory and accelerated long-term forgetting in cognitively unimpaired subjects
title_full_unstemmed Design and validation of the 1-week memory battery for assessing episodic memory and accelerated long-term forgetting in cognitively unimpaired subjects
title_sort Design and validation of the 1-week memory battery for assessing episodic memory and accelerated long-term forgetting in cognitively unimpaired subjects
dc.creator.none.fl_str_mv Rami González, Lorena
León, María
Valech, Natalia
Coll Padrós, Nina
Bosch, Beatriz
Olives, Jaume
Salinero, Ana
Pérez Millan, Agnès
Molinuevo, José Luis
Sánchez Valle, Raquel
Tort Merino, Adrià
author Rami González, Lorena
author_facet Rami González, Lorena
León, María
Valech, Natalia
Coll Padrós, Nina
Bosch, Beatriz
Olives, Jaume
Salinero, Ana
Pérez Millan, Agnès
Molinuevo, José Luis
Sánchez Valle, Raquel
Tort Merino, Adrià
author_role author
author2 León, María
Valech, Natalia
Coll Padrós, Nina
Bosch, Beatriz
Olives, Jaume
Salinero, Ana
Pérez Millan, Agnès
Molinuevo, José Luis
Sánchez Valle, Raquel
Tort Merino, Adrià
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia d'Alzheimer
Funcions executives (Neuropsicologia)
Alzheimer's disease
Executive functions (Neuropsychology)
topic Malaltia d'Alzheimer
Funcions executives (Neuropsicologia)
Alzheimer's disease
Executive functions (Neuropsychology)
description Subtle decline in memory is thought to arise in the preclinical phase of Alzheimer's disease (AD). However, detecting these initial cognitive difficulties cross-sectionally has been challenging, and the exact nature of the decline is still debated. Accelerated long-term forgetting (ALF) has been recently suggested as one of the earliest and most sensitive indicators of memory dysfunction in subjects at risk of developing AD. The objective of this study was to design and validate the 1-week memory battery (1WMB) for assessing episodic memory and ALF in cognitively unimpaired individuals.The 1WMB is unique in that it assesses multimodal memory and measures recall at both short delay (20 min) and at long term (1 week). Forty-five cognitively unimpaired subjects were assessed with 1WMB and standardized neuropsychological tests. Subjective cognitive decline (SCD), levels of anxiety and depression, and cognitive reserve were also measured.The tests of 1WMB showed a high internal consistency, and concurrent validity was observed with standard tests of episodic memory and executive functions. The analysis revealed a greater loss of information at 1 week compared to short-term forgetting (20 min). Performance in the 1WMB was affected by age and educational level, but was not associated with levels of anxiety and depression. Unlike standard tests, performance in the 1WMB correlated with measures of SCD.Our findings indicate that the 1WMB has good psychometric properties, and future studies are needed to explore its potential usefulness to assess cognitively unimpaired subjects at increased risk of developing AD. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/206200
url https://hdl.handle.net/2445/206200
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1037/neu0000879
Neuropsychology, 2023, vol. 37, num. 6, p. 683-697
https://doi.org/10.1037/neu0000879
dc.rights.none.fl_str_mv (c) Neuropsychology, 2023
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Neuropsychology, 2023
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 41 p.
application/pdf
dc.source.none.fl_str_mv Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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