Genome-wide expression profiling of B lymphocytes reveals IL4R increase in allergic asthma
[EN] Allergic asthma is a multifactorial disorder in which activation and differentiation of B lymphocytes toward the production of IgE play an essential role. In these B cells, molecular mechanisms to generate IgE antibodies from IgM depend on a complex network of molecules that trigger class-switc...
| Authors: | , , , , , , , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2014 |
| Country: | España |
| Institution: | Universidad de Salamanca (USAL) |
| Repository: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:gredos.usal.es:10366/158887 |
| Online Access: | https://doi.org/10.1016/j.jaci.2014.05.015 http://hdl.handle.net/10366/158887 |
| Access Level: | Open access |
| Keyword: | asthma Allergic asthma IgE genome-wide B lymphocytes polymorphisms Genetics Allergy and Immunology 3207.01 Alergias 2409 Genética alergia e inmunología genética |
| Summary: | [EN] Allergic asthma is a multifactorial disorder in which activation and differentiation of B lymphocytes toward the production of IgE play an essential role. In these B cells, molecular mechanisms to generate IgE antibodies from IgM depend on a complex network of molecules that trigger class-switch recombination specifically at the Sε region of the IgH locus. Several trans-membrane receptors and activating signaling cascades are known to physiologically participate in these processes, including the IL4R signaling pathway. In this regard, our group has studied in the past genetic polymorphisms in the IL4/IL4R pathway that might hold clinical correlations with atopy and asthma. |
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