Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas Project

Cognitive abilities, particularly memory, normally decline with age. However, some individuals, often designated as superagers, can reach late life with the memory function of individuals 30 years younger. We aimed to characterise the brain structure of superagers and identify demographic, lifestyle...

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Detalhes bibliográficos
Autores: Garo-Pascual, Marta, Gaser, Christian, Zhang, Linda, Tohka, Jussi, Medina, Miguel, Strange, Bryan A
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/389016
Acesso em linha:http://hdl.handle.net/10261/389016
https://api.elsevier.com/content/abstract/scopus_id/85166665733
Access Level:acceso abierto
Palavra-chave:http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
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spelling Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas ProjectGaro-Pascual, MartaGaser, ChristianZhang, LindaTohka, JussiMedina, MiguelStrange, Bryan Ahttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesCognitive abilities, particularly memory, normally decline with age. However, some individuals, often designated as superagers, can reach late life with the memory function of individuals 30 years younger. We aimed to characterise the brain structure of superagers and identify demographic, lifestyle, and clinical factors associated with this phenotype.This work was supported by the CIEN Foundation and the Queen Sofia Foundation, as well as by grants from the Spanish Ministry of Science and Innovation to BAS (PID2020-119302RB-I00) and MM (PID2019110401RB-I00). MG-P was supported by a MAPFRE-Queen Sofia Foundation scholarship. CG received support from Carl Zeiss Foundation as a part of the IMPULS project (IMPULS P2019-01-006), and the Marie Skłodowska-Curie Innovative Training Network (SmartAge 859890 H2020-MSCA-ITN2019). LZ was supported by a grant (2016-NIRG-397128) from the Alzheimer’s Association to BAS. This work has received funding (reference ERC-2018-COG 819814) from the European Research Council under the European Union’s Horizon 2020 research and innovation programme. We thank the participants of the Vallecas Project and the staff of the CIEN Foundation.Peer reviewedElsevierFundación Reina SofíaFundación Centro de Investigación de Enfermedades NeurológicasMinisterio de Ciencia e Innovación (España)Alzheimer's AssociationEuropean CommissionFundación MapfreCarl Zeiss FoundationConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/389016https://api.elsevier.com/content/abstract/scopus_id/85166665733reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1016/S2666-7568(23)00079-XSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3890162026-05-22T06:33:51Z
dc.title.none.fl_str_mv Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas Project
title Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas Project
spellingShingle Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas Project
Garo-Pascual, Marta
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas Project
title_full Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas Project
title_fullStr Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas Project
title_full_unstemmed Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas Project
title_sort Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas Project
dc.creator.none.fl_str_mv Garo-Pascual, Marta
Gaser, Christian
Zhang, Linda
Tohka, Jussi
Medina, Miguel
Strange, Bryan A
author Garo-Pascual, Marta
author_facet Garo-Pascual, Marta
Gaser, Christian
Zhang, Linda
Tohka, Jussi
Medina, Miguel
Strange, Bryan A
author_role author
author2 Gaser, Christian
Zhang, Linda
Tohka, Jussi
Medina, Miguel
Strange, Bryan A
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Fundación Reina Sofía
Fundación Centro de Investigación de Enfermedades Neurológicas
Ministerio de Ciencia e Innovación (España)
Alzheimer's Association
European Commission
Fundación Mapfre
Carl Zeiss Foundation
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description Cognitive abilities, particularly memory, normally decline with age. However, some individuals, often designated as superagers, can reach late life with the memory function of individuals 30 years younger. We aimed to characterise the brain structure of superagers and identify demographic, lifestyle, and clinical factors associated with this phenotype.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/389016
https://api.elsevier.com/content/abstract/scopus_id/85166665733
url http://hdl.handle.net/10261/389016
https://api.elsevier.com/content/abstract/scopus_id/85166665733
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/S2666-7568(23)00079-X
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
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collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
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