Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice

Ribe, E. (Elena M.)|||/items/be6e661d-2ae2-4d62-a3dc-f471b4b237c7; Perez, M. (Mar)|||/items/aa515d3d-0299-4983-88cb-15574f926786; Puig, B. (Berta)|||/items/ee7709fc-cb96-4554-a27c-ae5c0372a641; Gich, I. (Ignasi)|||/items/04d99995-294c-4ecb-a83d-dcde295d7594; Lim, F. (Filip)|||/items/268280cf-d793-46fb-aef8-8f2a120f3091; Cuadrado-Tejedor, M. (Mar)|||/items/8e19b277-1821-4ae8-9617-975de11dbdd1; Sesma, T. (Teresa)|||/items/2a71f446-1a8a-4751-be29-4acdb5198106; Catena, S. (Silvia)|||/items/bbf7e212-b6d5-4d6e-b2ff-a8f1a76ef941; Sanchez, B. (Belén)|||/items/256ffe12-09d7-40e9-b8bf-e7208a0fd22d; Nieto, M. (María)|||/items/74cf22d8-0e19-4d9b-b337-1d762346e295; Ramos, P. (Pilar)|||/items/8117329a-a1ba-4aa5-a8b8-5e963f214ac5; Moran, M.A. (María Asunción)|||/items/bf6d94bf-25f5-40f0-ae8c-4855258957b8; Cabodevilla, F. (Felipe)|||/items/3adf8442-0a9f-443c-9aa2-037a873eb11e; Samaranch, L. (Lluis)|||/items/7c873660-9bf7-4191-bcc3-68e7cebb6c72; Ortiz, L. (Lourdes)|||/items/8b0adbb3-2bda-40f4-a1b2-7e5d971155de; Perez-Mediavilla, L.A. (Luis Alberto)|||/items/276fc9af-5d47-49eb-bf67-6d35fc210186; Ferrer, I. (Isidro)|||/items/90a4f031-75d5-4865-a115-487f50787723; Avila, J. (Jesús)|||/items/2757ce4f-661c-40c0-987f-bc824240a9b6; Gomez-Isla, T. (Teresa)|||/items/8da50b46-8433-4926-89b6-b4b6de1f9e49

Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice

Even though the idea that amyloid beta peptide accumulation is the primary event in the pathogenesis of Alzheimer's disease has become the leading hypothesis, the causal link between aberrant amyloid precursor protein processing and tau alterations in this type of dementia remains controversial...

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Autores:	Ribe, E. (Elena M.)\|\|\|/items/be6e661d-2ae2-4d62-a3dc-f471b4b237c7, Perez, M. (Mar)\|\|\|/items/aa515d3d-0299-4983-88cb-15574f926786, Puig, B. (Berta)\|\|\|/items/ee7709fc-cb96-4554-a27c-ae5c0372a641, Gich, I. (Ignasi)\|\|\|/items/04d99995-294c-4ecb-a83d-dcde295d7594, Lim, F. (Filip)\|\|\|/items/268280cf-d793-46fb-aef8-8f2a120f3091, Cuadrado-Tejedor, M. (Mar)\|\|\|/items/8e19b277-1821-4ae8-9617-975de11dbdd1, Sesma, T. (Teresa)\|\|\|/items/2a71f446-1a8a-4751-be29-4acdb5198106, Catena, S. (Silvia)\|\|\|/items/bbf7e212-b6d5-4d6e-b2ff-a8f1a76ef941, Sanchez, B. (Belén)\|\|\|/items/256ffe12-09d7-40e9-b8bf-e7208a0fd22d, Nieto, M. (María)\|\|\|/items/74cf22d8-0e19-4d9b-b337-1d762346e295, Ramos, P. (Pilar)\|\|\|/items/8117329a-a1ba-4aa5-a8b8-5e963f214ac5, Moran, M.A. (María Asunción)\|\|\|/items/bf6d94bf-25f5-40f0-ae8c-4855258957b8, Cabodevilla, F. (Felipe)\|\|\|/items/3adf8442-0a9f-443c-9aa2-037a873eb11e, Samaranch, L. (Lluis)\|\|\|/items/7c873660-9bf7-4191-bcc3-68e7cebb6c72, Ortiz, L. (Lourdes)\|\|\|/items/8b0adbb3-2bda-40f4-a1b2-7e5d971155de, Perez-Mediavilla, L.A. (Luis Alberto)\|\|\|/items/276fc9af-5d47-49eb-bf67-6d35fc210186, Ferrer, I. (Isidro)\|\|\|/items/90a4f031-75d5-4865-a115-487f50787723, Avila, J. (Jesús)\|\|\|/items/2757ce4f-661c-40c0-987f-bc824240a9b6, Gomez-Isla, T. (Teresa)\|\|\|/items/8da50b46-8433-4926-89b6-b4b6de1f9e49
Tipo de recurso:	artículo
Fecha de publicación:	2005
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/19659
Acceso en línea:	https://hdl.handle.net/10171/19659
Access Level:	acceso abierto
Palabra clave:	APP Beta-amyloid Tau Lisosomes Stereology Neuronal loss Transgenic mice Alzheimer’s disease

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spelling	Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic miceRibe, E. (Elena M.)\|\|\|/items/be6e661d-2ae2-4d62-a3dc-f471b4b237c7Perez, M. (Mar)\|\|\|/items/aa515d3d-0299-4983-88cb-15574f926786Puig, B. (Berta)\|\|\|/items/ee7709fc-cb96-4554-a27c-ae5c0372a641Gich, I. (Ignasi)\|\|\|/items/04d99995-294c-4ecb-a83d-dcde295d7594Lim, F. (Filip)\|\|\|/items/268280cf-d793-46fb-aef8-8f2a120f3091Cuadrado-Tejedor, M. (Mar)\|\|\|/items/8e19b277-1821-4ae8-9617-975de11dbdd1Sesma, T. (Teresa)\|\|\|/items/2a71f446-1a8a-4751-be29-4acdb5198106Catena, S. (Silvia)\|\|\|/items/bbf7e212-b6d5-4d6e-b2ff-a8f1a76ef941Sanchez, B. (Belén)\|\|\|/items/256ffe12-09d7-40e9-b8bf-e7208a0fd22dNieto, M. (María)\|\|\|/items/74cf22d8-0e19-4d9b-b337-1d762346e295Ramos, P. (Pilar)\|\|\|/items/8117329a-a1ba-4aa5-a8b8-5e963f214ac5Moran, M.A. (María Asunción)\|\|\|/items/bf6d94bf-25f5-40f0-ae8c-4855258957b8Cabodevilla, F. (Felipe)\|\|\|/items/3adf8442-0a9f-443c-9aa2-037a873eb11eSamaranch, L. (Lluis)\|\|\|/items/7c873660-9bf7-4191-bcc3-68e7cebb6c72Ortiz, L. (Lourdes)\|\|\|/items/8b0adbb3-2bda-40f4-a1b2-7e5d971155dePerez-Mediavilla, L.A. (Luis Alberto)\|\|\|/items/276fc9af-5d47-49eb-bf67-6d35fc210186Ferrer, I. (Isidro)\|\|\|/items/90a4f031-75d5-4865-a115-487f50787723Avila, J. (Jesús)\|\|\|/items/2757ce4f-661c-40c0-987f-bc824240a9b6Gomez-Isla, T. (Teresa)\|\|\|/items/8da50b46-8433-4926-89b6-b4b6de1f9e49APPBeta-amyloidTauLisosomesStereologyNeuronal lossTransgenic miceAlzheimer’s diseaseEven though the idea that amyloid beta peptide accumulation is the primary event in the pathogenesis of Alzheimer's disease has become the leading hypothesis, the causal link between aberrant amyloid precursor protein processing and tau alterations in this type of dementia remains controversial. We further investigated the role of beta-amyloid production/deposition in tau pathology and neuronal cell death in the mouse brain by crossing Tg2576 and VLW lines expressing human mutant amyloid precursor protein and human mutant tau, respectively. The resulting double transgenic mice showed enhanced amyloid deposition accompanied by neurofibrillary degeneration and overt neuronal loss in selectively vulnerable brain limbic areas. These findings challenge the idea that tau pathology in Alzheimer's disease is merely a downstream effect of amyloid production/deposition and suggest that reciprocal interactions between beta-amyloid and tau alterations may take place in vivo.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20112011-11-1420052005-01-0120052005-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/19659reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/196592026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice
title	Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice
spellingShingle	Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice Ribe, E. (Elena M.)\|\|\|/items/be6e661d-2ae2-4d62-a3dc-f471b4b237c7 APP Beta-amyloid Tau Lisosomes Stereology Neuronal loss Transgenic mice Alzheimer’s disease
title_short	Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice
title_full	Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice
title_fullStr	Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice
title_full_unstemmed	Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice
title_sort	Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice
dc.creator.none.fl_str_mv	Ribe, E. (Elena M.)\|\|\|/items/be6e661d-2ae2-4d62-a3dc-f471b4b237c7 Perez, M. (Mar)\|\|\|/items/aa515d3d-0299-4983-88cb-15574f926786 Puig, B. (Berta)\|\|\|/items/ee7709fc-cb96-4554-a27c-ae5c0372a641 Gich, I. (Ignasi)\|\|\|/items/04d99995-294c-4ecb-a83d-dcde295d7594 Lim, F. (Filip)\|\|\|/items/268280cf-d793-46fb-aef8-8f2a120f3091 Cuadrado-Tejedor, M. (Mar)\|\|\|/items/8e19b277-1821-4ae8-9617-975de11dbdd1 Sesma, T. (Teresa)\|\|\|/items/2a71f446-1a8a-4751-be29-4acdb5198106 Catena, S. (Silvia)\|\|\|/items/bbf7e212-b6d5-4d6e-b2ff-a8f1a76ef941 Sanchez, B. (Belén)\|\|\|/items/256ffe12-09d7-40e9-b8bf-e7208a0fd22d Nieto, M. (María)\|\|\|/items/74cf22d8-0e19-4d9b-b337-1d762346e295 Ramos, P. (Pilar)\|\|\|/items/8117329a-a1ba-4aa5-a8b8-5e963f214ac5 Moran, M.A. (María Asunción)\|\|\|/items/bf6d94bf-25f5-40f0-ae8c-4855258957b8 Cabodevilla, F. (Felipe)\|\|\|/items/3adf8442-0a9f-443c-9aa2-037a873eb11e Samaranch, L. (Lluis)\|\|\|/items/7c873660-9bf7-4191-bcc3-68e7cebb6c72 Ortiz, L. (Lourdes)\|\|\|/items/8b0adbb3-2bda-40f4-a1b2-7e5d971155de Perez-Mediavilla, L.A. (Luis Alberto)\|\|\|/items/276fc9af-5d47-49eb-bf67-6d35fc210186 Ferrer, I. (Isidro)\|\|\|/items/90a4f031-75d5-4865-a115-487f50787723 Avila, J. (Jesús)\|\|\|/items/2757ce4f-661c-40c0-987f-bc824240a9b6 Gomez-Isla, T. (Teresa)\|\|\|/items/8da50b46-8433-4926-89b6-b4b6de1f9e49
author	Ribe, E. (Elena M.)\|\|\|/items/be6e661d-2ae2-4d62-a3dc-f471b4b237c7
author_facet	Ribe, E. (Elena M.)\|\|\|/items/be6e661d-2ae2-4d62-a3dc-f471b4b237c7 Perez, M. (Mar)\|\|\|/items/aa515d3d-0299-4983-88cb-15574f926786 Puig, B. (Berta)\|\|\|/items/ee7709fc-cb96-4554-a27c-ae5c0372a641 Gich, I. (Ignasi)\|\|\|/items/04d99995-294c-4ecb-a83d-dcde295d7594 Lim, F. (Filip)\|\|\|/items/268280cf-d793-46fb-aef8-8f2a120f3091 Cuadrado-Tejedor, M. (Mar)\|\|\|/items/8e19b277-1821-4ae8-9617-975de11dbdd1 Sesma, T. (Teresa)\|\|\|/items/2a71f446-1a8a-4751-be29-4acdb5198106 Catena, S. (Silvia)\|\|\|/items/bbf7e212-b6d5-4d6e-b2ff-a8f1a76ef941 Sanchez, B. (Belén)\|\|\|/items/256ffe12-09d7-40e9-b8bf-e7208a0fd22d Nieto, M. (María)\|\|\|/items/74cf22d8-0e19-4d9b-b337-1d762346e295 Ramos, P. (Pilar)\|\|\|/items/8117329a-a1ba-4aa5-a8b8-5e963f214ac5 Moran, M.A. (María Asunción)\|\|\|/items/bf6d94bf-25f5-40f0-ae8c-4855258957b8 Cabodevilla, F. (Felipe)\|\|\|/items/3adf8442-0a9f-443c-9aa2-037a873eb11e Samaranch, L. (Lluis)\|\|\|/items/7c873660-9bf7-4191-bcc3-68e7cebb6c72 Ortiz, L. (Lourdes)\|\|\|/items/8b0adbb3-2bda-40f4-a1b2-7e5d971155de Perez-Mediavilla, L.A. (Luis Alberto)\|\|\|/items/276fc9af-5d47-49eb-bf67-6d35fc210186 Ferrer, I. (Isidro)\|\|\|/items/90a4f031-75d5-4865-a115-487f50787723 Avila, J. (Jesús)\|\|\|/items/2757ce4f-661c-40c0-987f-bc824240a9b6 Gomez-Isla, T. (Teresa)\|\|\|/items/8da50b46-8433-4926-89b6-b4b6de1f9e49
author_role	author
author2	Perez, M. (Mar)\|\|\|/items/aa515d3d-0299-4983-88cb-15574f926786 Puig, B. (Berta)\|\|\|/items/ee7709fc-cb96-4554-a27c-ae5c0372a641 Gich, I. (Ignasi)\|\|\|/items/04d99995-294c-4ecb-a83d-dcde295d7594 Lim, F. (Filip)\|\|\|/items/268280cf-d793-46fb-aef8-8f2a120f3091 Cuadrado-Tejedor, M. (Mar)\|\|\|/items/8e19b277-1821-4ae8-9617-975de11dbdd1 Sesma, T. (Teresa)\|\|\|/items/2a71f446-1a8a-4751-be29-4acdb5198106 Catena, S. (Silvia)\|\|\|/items/bbf7e212-b6d5-4d6e-b2ff-a8f1a76ef941 Sanchez, B. (Belén)\|\|\|/items/256ffe12-09d7-40e9-b8bf-e7208a0fd22d Nieto, M. (María)\|\|\|/items/74cf22d8-0e19-4d9b-b337-1d762346e295 Ramos, P. (Pilar)\|\|\|/items/8117329a-a1ba-4aa5-a8b8-5e963f214ac5 Moran, M.A. (María Asunción)\|\|\|/items/bf6d94bf-25f5-40f0-ae8c-4855258957b8 Cabodevilla, F. (Felipe)\|\|\|/items/3adf8442-0a9f-443c-9aa2-037a873eb11e Samaranch, L. (Lluis)\|\|\|/items/7c873660-9bf7-4191-bcc3-68e7cebb6c72 Ortiz, L. (Lourdes)\|\|\|/items/8b0adbb3-2bda-40f4-a1b2-7e5d971155de Perez-Mediavilla, L.A. (Luis Alberto)\|\|\|/items/276fc9af-5d47-49eb-bf67-6d35fc210186 Ferrer, I. (Isidro)\|\|\|/items/90a4f031-75d5-4865-a115-487f50787723 Avila, J. (Jesús)\|\|\|/items/2757ce4f-661c-40c0-987f-bc824240a9b6 Gomez-Isla, T. (Teresa)\|\|\|/items/8da50b46-8433-4926-89b6-b4b6de1f9e49
author2_role	author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	APP Beta-amyloid Tau Lisosomes Stereology Neuronal loss Transgenic mice Alzheimer’s disease
topic	APP Beta-amyloid Tau Lisosomes Stereology Neuronal loss Transgenic mice Alzheimer’s disease
description	Even though the idea that amyloid beta peptide accumulation is the primary event in the pathogenesis of Alzheimer's disease has become the leading hypothesis, the causal link between aberrant amyloid precursor protein processing and tau alterations in this type of dementia remains controversial. We further investigated the role of beta-amyloid production/deposition in tau pathology and neuronal cell death in the mouse brain by crossing Tg2576 and VLW lines expressing human mutant amyloid precursor protein and human mutant tau, respectively. The resulting double transgenic mice showed enhanced amyloid deposition accompanied by neurofibrillary degeneration and overt neuronal loss in selectively vulnerable brain limbic areas. These findings challenge the idea that tau pathology in Alzheimer's disease is merely a downstream effect of amyloid production/deposition and suggest that reciprocal interactions between beta-amyloid and tau alterations may take place in vivo.
publishDate	2005
dc.date.none.fl_str_mv	2005 2005-01-01 2005 2005-01-01 2011 2011-11-14
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/19659
url	https://hdl.handle.net/10171/19659
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.228081

Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice

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