Voltammetric determination of antihypertensive drug hydrochlorothiazide using screen-printed electrodes modified with L- glutamic acid
This work deals with the development of screen-printed carbon electrodes modified with L-glutamic acid via two different approaches: electropolymerization (SPCE/PGA) and aryl diazonium electrochemical grafting (SPCE/EGA). SPCE/PGA and SPCE/EGA were analytically compared in the determination of hydro...
| Autores: | , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2017 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositório: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/116084 |
| Acesso em linha: | https://hdl.handle.net/2445/116084 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Anàlisi electroquímica Voltametria Electrochemical analysis Voltammetry |
| Resumo: | This work deals with the development of screen-printed carbon electrodes modified with L-glutamic acid via two different approaches: electropolymerization (SPCE/PGA) and aryl diazonium electrochemical grafting (SPCE/EGA). SPCE/PGA and SPCE/EGA were analytically compared in the determination of hydrochlorothiazide (HCTZ) by differential pulse voltammetry. Both electrochemical characterization and analytical performance indicate that SPCE/EGA is a much better sensor for HCTZ. The detection and quantification limits were at the level of micromol L-1 with a very good linearity in the studied concentration range. In addition, the proposed SPCE/EGA was successfully applied for the determination of HCTZ in an anti-hypertensive drug with high reproducibility and good trueness. |
|---|