Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets
Attention-deficit; Brain asymmetry; Hyperactivity disorder
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/7762 |
| Acceso en línea: | https://hdl.handle.net/11351/7762 |
| Access Level: | acceso abierto |
| Palabra clave: | Trastorn per dèficit d'atenció amb hiperactivitat Cervell - Imatgeria Dominància cerebral PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity ANATOMY::Nervous System::Central Nervous System::Brain Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Child Development Disorders, Pervasive::Autism Spectrum Disorder PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos generalizados del desarrollo del niño::trastorno del espectro del autismo |
| id |
ES_b7a863bb776ab117811d41f7bebf6b8e |
|---|---|
| oai_identifier_str |
oai:scientiasalut.gencat.cat:11351/7762 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| dc.title.none.fl_str_mv |
Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets |
| title |
Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets |
| spellingShingle |
Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets Postema, Merel C. Trastorn per dèficit d'atenció amb hiperactivitat Cervell - Imatgeria Dominància cerebral PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity ANATOMY::Nervous System::Central Nervous System::Brain Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Child Development Disorders, Pervasive::Autism Spectrum Disorder PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos generalizados del desarrollo del niño::trastorno del espectro del autismo |
| title_short |
Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets |
| title_full |
Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets |
| title_fullStr |
Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets |
| title_full_unstemmed |
Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets |
| title_sort |
Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets |
| dc.creator.none.fl_str_mv |
Postema, Merel C. Hoogman, Martine Ambrosino, Sara Asherson, Philip Banaschewski, Tobias Edom Bandeira, Cibele Ramos-Quiroga, Josep Antoni |
| author |
Postema, Merel C. |
| author_facet |
Postema, Merel C. Hoogman, Martine Ambrosino, Sara Asherson, Philip Banaschewski, Tobias Edom Bandeira, Cibele Ramos-Quiroga, Josep Antoni |
| author_role |
author |
| author2 |
Hoogman, Martine Ambrosino, Sara Asherson, Philip Banaschewski, Tobias Edom Bandeira, Cibele Ramos-Quiroga, Josep Antoni |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Postema MC] Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. [Hoogman M] Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands. Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands. [Ambrosino S] NICHE lab, Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands. [Asherson P] Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK. [Banaschewski T] Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany. [Bandeira CE] Adulthood ADHD Outpatient Program (ProDAH), Clinical Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. Department of Genetics, Institute of Biosciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. [Ramos-Quiroga JA] Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Catalonia, Spain. Departament de Psiquiatria i Medicina Legal, Universitat Autònoma de Barcelona, Bellaterra, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Trastorn per dèficit d'atenció amb hiperactivitat Cervell - Imatgeria Dominància cerebral PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity ANATOMY::Nervous System::Central Nervous System::Brain Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Child Development Disorders, Pervasive::Autism Spectrum Disorder PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos generalizados del desarrollo del niño::trastorno del espectro del autismo |
| topic |
Trastorn per dèficit d'atenció amb hiperactivitat Cervell - Imatgeria Dominància cerebral PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity ANATOMY::Nervous System::Central Nervous System::Brain Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Child Development Disorders, Pervasive::Autism Spectrum Disorder PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos generalizados del desarrollo del niño::trastorno del espectro del autismo |
| description |
Attention-deficit; Brain asymmetry; Hyperactivity disorder |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/7762 |
| url |
https://hdl.handle.net/11351/7762 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Journal of Child Psychology and Psychiatry;62(10) https://doi.org/10.1111/jcpp.13396 |
| dc.rights.none.fl_str_mv |
Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley |
| publisher.none.fl_str_mv |
Wiley |
| dc.source.none.fl_str_mv |
Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
| instname_str |
Departament de Salut de la Generalitat de Catalunya (DS) |
| reponame_str |
Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| collection |
Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869417547254726656 |
| spelling |
Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasetsPostema, Merel C.Hoogman, MartineAmbrosino, SaraAsherson, PhilipBanaschewski, TobiasEdom Bandeira, CibeleRamos-Quiroga, Josep AntoniTrastorn per dèficit d'atenció amb hiperactivitatCervell - ImatgeriaDominància cerebralPSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with HyperactivityANATOMY::Nervous System::Central Nervous System::BrainOther subheadings::Other subheadings::Other subheadings::/diagnostic imagingPSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Child Development Disorders, Pervasive::Autism Spectrum DisorderPSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividadANATOMÍA::sistema nervioso::sistema nervioso central::encéfaloOtros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagenPSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos generalizados del desarrollo del niño::trastorno del espectro del autismoAttention-deficit; Brain asymmetry; Hyperactivity disorderDeficit de atención; Asimetría cerebral; Trastorno de hiperactividadDèficit d’atenció; Asimetria cerebral; Trastorn d'hiperactivitatObjective Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium. Methods We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries. Results There was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen’s d from −0.18 to 0.18) and would not survive study-wide correction for multiple testing. Conclusion Prior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.WileyInstitut Català de la Salut[Postema MC] Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. [Hoogman M] Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands. Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands. [Ambrosino S] NICHE lab, Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands. [Asherson P] Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK. [Banaschewski T] Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany. [Bandeira CE] Adulthood ADHD Outpatient Program (ProDAH), Clinical Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. Department of Genetics, Institute of Biosciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. [Ramos-Quiroga JA] Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Catalonia, Spain. Departament de Psiquiatria i Medicina Legal, Universitat Autònoma de Barcelona, Bellaterra, SpainVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11351/7762Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésJournal of Child Psychology and Psychiatry;62(10)https://doi.org/10.1111/jcpp.13396Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/77622026-06-12T09:38:37Z |
| score |
15.223283 |