Secondhand tobacco smoke and functional impairments in older adults living in the community
Background/aim: there has been no comprehensive examination of the potential association of SHS with broad functional limitation assessment in older adults, where functional limitations are burdensome and challenging. Methods: we examined 2258 community-dwelling non-smoking older adults from the Sen...
| Autores: | , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2022 |
| País: | España |
| Recursos: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/55027 |
| Acesso em linha: | http://hdl.handle.net/10230/55027 http://dx.doi.org/10.1093/ntr/ntac131 |
| Access Level: | acceso abierto |
| Palavra-chave: | Tabac--Efectes fisiològics Tabaquisme Contaminació--Aspectes ambientals |
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Secondhand tobacco smoke and functional impairments in older adults living in the communityCraciun, Oana M.Ortolá, RosarioPascual Esteban, José A.Pérez Ortuño, Raúl, 1976-Galán, IñakiBanegas, Jose R.Rodríguez Artalejo, FernandoGarcía-Esquinas, EstherTabac--Efectes fisiològicsTabaquismeContaminació--Aspectes ambientalsBackground/aim: there has been no comprehensive examination of the potential association of SHS with broad functional limitation assessment in older adults, where functional limitations are burdensome and challenging. Methods: we examined 2258 community-dwelling non-smoking older adults from the Seniors-Enrica-2-cohort. At baseline (2017) and follow-up (2019) grip strength was measured with a Jamar dynamometer, lower-extremity performance with the Short Physical Performance Battery (SPPB), overall physical function using the physical component summary (PCS) of the Spanish version of the SF-12, frailty with a Deficits Accumulation Index (DAI), and mobility limitations with the Rosow-Breslau scale. Baseline exposure to SHS was assessed by serum cotinine, and past exposure was self-reported. Cross-sectional analyses were performed using linear and logistic regression models, whereas functional performance changes were examined using repeated measures models with robust SE estimates. Results: overall, the median (IQR) serum cotinine concentration was 0.079 (0.035-0.175) ng/ml, with 20 participants presenting concentrations ≥3 ng/ml. Compared to the unexposed, fully-adjusted models showed that the highest exposure group (≥0.239 ng/ml) presented lower grip strength (mean difference: -1.05 kg; 95% CI = -1.80, -0.31) and higher DAI scores (1.52; 95% CI = 0.38, 2.66) at baseline. Similarly, in models of self-reported past exposure, never-smokers who had lived with ≥2 smokers or been exposed to higher SHS cumulative doses showed lower baseline SPPB values, higher DAI scores, and higher prevalence of mobility limitations. In prospective analyses, those in the highest quartile of baseline cotinine presented harmful SPPB [-0.24 (-0.46, -0.02)] and DAI [1.28 (0.00, 2.55)] changes, and higher risk of mobility limitations [hazard ratio: 1.64; 95% CI = 1.01, 2.68] than the unexposed. Conclusions: SHS exposure over the life-course and during old age may accelerate functional decline. Implications: this manuscript provides a comprehensive examination of the relationship between secondhand smoke exposure and a broad range of functional limitations in older adults. Results show that: (i) non-smokers who had been exposed to higher cumulative doses of SHS in adulthood show worse physical function than non-exposed. (ii) Exposure to SHS during old age, as measured with cotinine concentrations, is associated with accelerated short-term functional declines. (iii) The effects of SHS are stronger among older adults with chronic morbidities. (iv) Results suggest that more efforts are needed to protect older adults from passive smoking, especially to those with chronic conditions because of their potential greater vulnerability to the effects of SHS.Oxford University Press20222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/55027http://dx.doi.org/10.1093/ntr/ntac131reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglés© Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in Nicotine & tobacco research following peer review. The version of record Craciun OM, Ortolá R, Pascual JA, Pérez-Ortuño R, Galán Labaca I, Banegas JR, et al. Secondhand tobacco smoke and functional impairments in older adults living in the community. Nicotine Tob Res. 2022 Nov 12; 24(12): 2026-34, is available online at: https://academic.oup.com/ntr/article-abstract/24/12/2026/6586052?redirectedFrom=fulltext&login=true.info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/550272026-06-12T07:21:37Z |
| dc.title.none.fl_str_mv |
Secondhand tobacco smoke and functional impairments in older adults living in the community |
| title |
Secondhand tobacco smoke and functional impairments in older adults living in the community |
| spellingShingle |
Secondhand tobacco smoke and functional impairments in older adults living in the community Craciun, Oana M. Tabac--Efectes fisiològics Tabaquisme Contaminació--Aspectes ambientals |
| title_short |
Secondhand tobacco smoke and functional impairments in older adults living in the community |
| title_full |
Secondhand tobacco smoke and functional impairments in older adults living in the community |
| title_fullStr |
Secondhand tobacco smoke and functional impairments in older adults living in the community |
| title_full_unstemmed |
Secondhand tobacco smoke and functional impairments in older adults living in the community |
| title_sort |
Secondhand tobacco smoke and functional impairments in older adults living in the community |
| dc.creator.none.fl_str_mv |
Craciun, Oana M. Ortolá, Rosario Pascual Esteban, José A. Pérez Ortuño, Raúl, 1976- Galán, Iñaki Banegas, Jose R. Rodríguez Artalejo, Fernando García-Esquinas, Esther |
| author |
Craciun, Oana M. |
| author_facet |
Craciun, Oana M. Ortolá, Rosario Pascual Esteban, José A. Pérez Ortuño, Raúl, 1976- Galán, Iñaki Banegas, Jose R. Rodríguez Artalejo, Fernando García-Esquinas, Esther |
| author_role |
author |
| author2 |
Ortolá, Rosario Pascual Esteban, José A. Pérez Ortuño, Raúl, 1976- Galán, Iñaki Banegas, Jose R. Rodríguez Artalejo, Fernando García-Esquinas, Esther |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
Tabac--Efectes fisiològics Tabaquisme Contaminació--Aspectes ambientals |
| topic |
Tabac--Efectes fisiològics Tabaquisme Contaminació--Aspectes ambientals |
| description |
Background/aim: there has been no comprehensive examination of the potential association of SHS with broad functional limitation assessment in older adults, where functional limitations are burdensome and challenging. Methods: we examined 2258 community-dwelling non-smoking older adults from the Seniors-Enrica-2-cohort. At baseline (2017) and follow-up (2019) grip strength was measured with a Jamar dynamometer, lower-extremity performance with the Short Physical Performance Battery (SPPB), overall physical function using the physical component summary (PCS) of the Spanish version of the SF-12, frailty with a Deficits Accumulation Index (DAI), and mobility limitations with the Rosow-Breslau scale. Baseline exposure to SHS was assessed by serum cotinine, and past exposure was self-reported. Cross-sectional analyses were performed using linear and logistic regression models, whereas functional performance changes were examined using repeated measures models with robust SE estimates. Results: overall, the median (IQR) serum cotinine concentration was 0.079 (0.035-0.175) ng/ml, with 20 participants presenting concentrations ≥3 ng/ml. Compared to the unexposed, fully-adjusted models showed that the highest exposure group (≥0.239 ng/ml) presented lower grip strength (mean difference: -1.05 kg; 95% CI = -1.80, -0.31) and higher DAI scores (1.52; 95% CI = 0.38, 2.66) at baseline. Similarly, in models of self-reported past exposure, never-smokers who had lived with ≥2 smokers or been exposed to higher SHS cumulative doses showed lower baseline SPPB values, higher DAI scores, and higher prevalence of mobility limitations. In prospective analyses, those in the highest quartile of baseline cotinine presented harmful SPPB [-0.24 (-0.46, -0.02)] and DAI [1.28 (0.00, 2.55)] changes, and higher risk of mobility limitations [hazard ratio: 1.64; 95% CI = 1.01, 2.68] than the unexposed. Conclusions: SHS exposure over the life-course and during old age may accelerate functional decline. Implications: this manuscript provides a comprehensive examination of the relationship between secondhand smoke exposure and a broad range of functional limitations in older adults. Results show that: (i) non-smokers who had been exposed to higher cumulative doses of SHS in adulthood show worse physical function than non-exposed. (ii) Exposure to SHS during old age, as measured with cotinine concentrations, is associated with accelerated short-term functional declines. (iii) The effects of SHS are stronger among older adults with chronic morbidities. (iv) Results suggest that more efforts are needed to protect older adults from passive smoking, especially to those with chronic conditions because of their potential greater vulnerability to the effects of SHS. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
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article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/55027 http://dx.doi.org/10.1093/ntr/ntac131 |
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http://hdl.handle.net/10230/55027 http://dx.doi.org/10.1093/ntr/ntac131 |
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Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf application/pdf |
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Oxford University Press |
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Oxford University Press |
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reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra |
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Universitat Pompeu Fabra |
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