Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE−/− Mice Experimental Model
[EN] Alzheimer’s disease (AD) is the main cause of dementia and cognitive impairment. It has been associated with a significant diminution of omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) levels in the brain. Clinical trials with DHA as a treatment in neurological diseases have shown...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universidad de León |
| Repositorio: | BULERIA. Repositorio Institucional de la Universidad de León |
| OAI Identifier: | oai:buleria.unileon.es:10612/24381 |
| Acceso en línea: | https://www.mdpi.com/2072-6643/11/1/11 https://hdl.handle.net/10612/24381 |
| Access Level: | acceso abierto |
| Palabra clave: | Bioquímica Medicina. Salud Alzheimer’s DHA ApoE -/- Phytanic acid Inflammation Neuroprotection Oxidation 3207.11 Neuropatología 2302.11 Acidos Grasos 2403 Bioquímica |
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Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE−/− Mice Experimental ModelRuiz-Roso Guerra, María BelénEcheverry Alzate, VíctorRuiz-Roso Calvo de Mora, BaltasarQuintela Fernández, José CarlosBallesteros Rodrigálvarez, Sandra MaríaLahera Juliá, VicenteHeras Jiménez, Natalia de lasLópez Moreno, José AntonioMartín Fernández, BeatrizBioquímicaMedicina. SaludAlzheimer’sDHAApoE -/-Phytanic acidInflammationNeuroprotectionOxidation3207.11 Neuropatología2302.11 Acidos Grasos2403 Bioquímica[EN] Alzheimer’s disease (AD) is the main cause of dementia and cognitive impairment. It has been associated with a significant diminution of omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) levels in the brain. Clinical trials with DHA as a treatment in neurological diseases have shown inconsistent results. Previously, we reported that the presence of phytanic acid (PhA) in standard DHA compositions could be blunting DHA’s beneficial effects. Therefore, we aimed to analyze the effects of a low PhA-concentrated DHA and a standard PhA-concentrated DHA in Apolipoprotein E knockout (ApoE−/−) mice. Behavioral tests and protein expression of pro-inflammatory, pro-oxidant, antioxidant factors, and AD-related mediators were evaluated. Low PhA-concentrated DHA decreased Aβ, ß-amyloid precursor protein (APP), p-tau, Ca2+/calmodulin-dependent protein kinase II (CAMKII), caspase 3, and catalase, and increased brain derived neurotrophic factor (BDNF) when compared to standard PhA-concentrated DHA. Low PhA-concentrated DHA decreased interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α) protein expression in ApoE−/− mice when compared to standard PhA-concentrated DHA. No significant differences were found in p22phox, inducible nitric oxide synthase (iNOS), glutathione peroxidase (GPx), superoxide dismutase 1 (SOD-1), and tau protein expression. The positive actions of a low PhA-concentrated DHA were functionally reflected by improving the cognitive deficit in the AD experimental model. Therefore, reduction of PhA content in DHA compositions could highlight a novel pathway for the neurodegeneration processes related to ADSIThis work was supported by grants from “Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016” (RTC-2014-1689-1) and the Fondo de Investigación Sanitaria (Red de Trastornos Adictivos, FEDER, RD16/0017/0008 to J.A.L.M.)MDPIBiologia CelularFacultad de Ciencias Biológicas y Ambientales2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://www.mdpi.com/2072-6643/11/1/11https://hdl.handle.net/10612/24381reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Universidad de LeónInglésinfo:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/RTC-2014-1689-1Q2818014IMADRIDinfo:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/RD16http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/243812026-06-24T12:43:27Z |
| dc.title.none.fl_str_mv |
Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE−/− Mice Experimental Model |
| title |
Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE−/− Mice Experimental Model |
| spellingShingle |
Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE−/− Mice Experimental Model Ruiz-Roso Guerra, María Belén Bioquímica Medicina. Salud Alzheimer’s DHA ApoE -/- Phytanic acid Inflammation Neuroprotection Oxidation 3207.11 Neuropatología 2302.11 Acidos Grasos 2403 Bioquímica |
| title_short |
Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE−/− Mice Experimental Model |
| title_full |
Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE−/− Mice Experimental Model |
| title_fullStr |
Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE−/− Mice Experimental Model |
| title_full_unstemmed |
Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE−/− Mice Experimental Model |
| title_sort |
Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE−/− Mice Experimental Model |
| dc.creator.none.fl_str_mv |
Ruiz-Roso Guerra, María Belén Echeverry Alzate, Víctor Ruiz-Roso Calvo de Mora, Baltasar Quintela Fernández, José Carlos Ballesteros Rodrigálvarez, Sandra María Lahera Juliá, Vicente Heras Jiménez, Natalia de las López Moreno, José Antonio Martín Fernández, Beatriz |
| author |
Ruiz-Roso Guerra, María Belén |
| author_facet |
Ruiz-Roso Guerra, María Belén Echeverry Alzate, Víctor Ruiz-Roso Calvo de Mora, Baltasar Quintela Fernández, José Carlos Ballesteros Rodrigálvarez, Sandra María Lahera Juliá, Vicente Heras Jiménez, Natalia de las López Moreno, José Antonio Martín Fernández, Beatriz |
| author_role |
author |
| author2 |
Echeverry Alzate, Víctor Ruiz-Roso Calvo de Mora, Baltasar Quintela Fernández, José Carlos Ballesteros Rodrigálvarez, Sandra María Lahera Juliá, Vicente Heras Jiménez, Natalia de las López Moreno, José Antonio Martín Fernández, Beatriz |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Biologia Celular Facultad de Ciencias Biológicas y Ambientales |
| dc.subject.none.fl_str_mv |
Bioquímica Medicina. Salud Alzheimer’s DHA ApoE -/- Phytanic acid Inflammation Neuroprotection Oxidation 3207.11 Neuropatología 2302.11 Acidos Grasos 2403 Bioquímica |
| topic |
Bioquímica Medicina. Salud Alzheimer’s DHA ApoE -/- Phytanic acid Inflammation Neuroprotection Oxidation 3207.11 Neuropatología 2302.11 Acidos Grasos 2403 Bioquímica |
| description |
[EN] Alzheimer’s disease (AD) is the main cause of dementia and cognitive impairment. It has been associated with a significant diminution of omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) levels in the brain. Clinical trials with DHA as a treatment in neurological diseases have shown inconsistent results. Previously, we reported that the presence of phytanic acid (PhA) in standard DHA compositions could be blunting DHA’s beneficial effects. Therefore, we aimed to analyze the effects of a low PhA-concentrated DHA and a standard PhA-concentrated DHA in Apolipoprotein E knockout (ApoE−/−) mice. Behavioral tests and protein expression of pro-inflammatory, pro-oxidant, antioxidant factors, and AD-related mediators were evaluated. Low PhA-concentrated DHA decreased Aβ, ß-amyloid precursor protein (APP), p-tau, Ca2+/calmodulin-dependent protein kinase II (CAMKII), caspase 3, and catalase, and increased brain derived neurotrophic factor (BDNF) when compared to standard PhA-concentrated DHA. Low PhA-concentrated DHA decreased interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α) protein expression in ApoE−/− mice when compared to standard PhA-concentrated DHA. No significant differences were found in p22phox, inducible nitric oxide synthase (iNOS), glutathione peroxidase (GPx), superoxide dismutase 1 (SOD-1), and tau protein expression. The positive actions of a low PhA-concentrated DHA were functionally reflected by improving the cognitive deficit in the AD experimental model. Therefore, reduction of PhA content in DHA compositions could highlight a novel pathway for the neurodegeneration processes related to AD |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://www.mdpi.com/2072-6643/11/1/11 https://hdl.handle.net/10612/24381 |
| url |
https://www.mdpi.com/2072-6643/11/1/11 https://hdl.handle.net/10612/24381 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
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info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/RTC-2014-1689-1Q2818014IMADRID info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/RD16 |
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http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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MDPI |
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MDPI |
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