Voltammetric determination of active pharmaceutical ingredients using screen-printed electrodes

A simple, fast, sensitive and low-cost voltammetric method using a screen-printed carbon electrode (SPCE) is presented in this work for the simultaneous determination of ascorbic acid (AA), paracetamol (PA), dextromethorphan (DX) and caffeine (CF) in both pharmaceutical formulations and samples of e...

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Detalhes bibliográficos
Autores: Clares, Paula, Pérez Ràfols, Clara, Serrano i Plana, Núria, Díaz Cruz, José Manuel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/185916
Acesso em linha:https://hdl.handle.net/2445/185916
Access Level:acceso abierto
Palavra-chave:Voltametria
Cafeïna
Elèctrodes
Voltammetry
Caffeine
Electrodes
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spelling Voltammetric determination of active pharmaceutical ingredients using screen-printed electrodesClares, PaulaPérez Ràfols, ClaraSerrano i Plana, NúriaDíaz Cruz, José ManuelVoltametriaCafeïnaElèctrodesVoltammetryCaffeineElectrodesA simple, fast, sensitive and low-cost voltammetric method using a screen-printed carbon electrode (SPCE) is presented in this work for the simultaneous determination of ascorbic acid (AA), paracetamol (PA), dextromethorphan (DX) and caffeine (CF) in both pharmaceutical formulations and samples of environmental interest. The oxidative peak current displayed linear dependence on concentration within the range 1.7-60.5, 0.6-40.0, 0.9-8.4 (1st linear part) and 1.8-22.0 mg L-1 for AA, PA, DX and CF, respectively; and detection limits of 0.5, 0.2, 0.3 and 0.5 mg L-1, respectively. The developed differential pulse voltammetric (DPV) method was validated using both a pharmaceutical product and a spiked well water sample. A very good agreement between the determined and the theoretical label drug content and recoveries in the range of 99.5-100.8% were obtained for pharmaceutical product and well water samples, respectively.MDPI2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/185916Articles publicats en revistes (Enginyeria Química i Química Analítica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/chemosensors10030095Chemosensors, 2022, vol. 10, num. 3, p. 95https://doi.org/10.3390/chemosensors10030095cc-by (c) Clares, Paula et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1859162026-05-29T05:05:01Z
dc.title.none.fl_str_mv Voltammetric determination of active pharmaceutical ingredients using screen-printed electrodes
title Voltammetric determination of active pharmaceutical ingredients using screen-printed electrodes
spellingShingle Voltammetric determination of active pharmaceutical ingredients using screen-printed electrodes
Clares, Paula
Voltametria
Cafeïna
Elèctrodes
Voltammetry
Caffeine
Electrodes
title_short Voltammetric determination of active pharmaceutical ingredients using screen-printed electrodes
title_full Voltammetric determination of active pharmaceutical ingredients using screen-printed electrodes
title_fullStr Voltammetric determination of active pharmaceutical ingredients using screen-printed electrodes
title_full_unstemmed Voltammetric determination of active pharmaceutical ingredients using screen-printed electrodes
title_sort Voltammetric determination of active pharmaceutical ingredients using screen-printed electrodes
dc.creator.none.fl_str_mv Clares, Paula
Pérez Ràfols, Clara
Serrano i Plana, Núria
Díaz Cruz, José Manuel
author Clares, Paula
author_facet Clares, Paula
Pérez Ràfols, Clara
Serrano i Plana, Núria
Díaz Cruz, José Manuel
author_role author
author2 Pérez Ràfols, Clara
Serrano i Plana, Núria
Díaz Cruz, José Manuel
author2_role author
author
author
dc.subject.none.fl_str_mv Voltametria
Cafeïna
Elèctrodes
Voltammetry
Caffeine
Electrodes
topic Voltametria
Cafeïna
Elèctrodes
Voltammetry
Caffeine
Electrodes
description A simple, fast, sensitive and low-cost voltammetric method using a screen-printed carbon electrode (SPCE) is presented in this work for the simultaneous determination of ascorbic acid (AA), paracetamol (PA), dextromethorphan (DX) and caffeine (CF) in both pharmaceutical formulations and samples of environmental interest. The oxidative peak current displayed linear dependence on concentration within the range 1.7-60.5, 0.6-40.0, 0.9-8.4 (1st linear part) and 1.8-22.0 mg L-1 for AA, PA, DX and CF, respectively; and detection limits of 0.5, 0.2, 0.3 and 0.5 mg L-1, respectively. The developed differential pulse voltammetric (DPV) method was validated using both a pharmaceutical product and a spiked well water sample. A very good agreement between the determined and the theoretical label drug content and recoveries in the range of 99.5-100.8% were obtained for pharmaceutical product and well water samples, respectively.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/185916
url https://hdl.handle.net/2445/185916
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/chemosensors10030095
Chemosensors, 2022, vol. 10, num. 3, p. 95
https://doi.org/10.3390/chemosensors10030095
dc.rights.none.fl_str_mv cc-by (c) Clares, Paula et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Clares, Paula et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Enginyeria Química i Química Analítica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,223283

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