Peste des petits ruminants virus (PPRV) modulates caprine dendritic cell function and induces immunosuppression through IL-10 upregulation

Peste des petits ruminants (PPR) is a WOAH notifiable disease affecting sheep and goats, caused by Peste des petits ruminants virus (PPRV), a morbillivirus of the Paramyxoviridae family. Infection with PPRV leads to immunosuppression, creating conditions for opportunistic infections that can result...

ver descrição completa

Detalhes bibliográficos
Autores: Nogales-Altozano, Pablo, Martínez Rodrigo, Abel, Rojas, José M, Sevilla, Noemí
Formato: artículo
Fecha de publicación:2026
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/133687
Acesso em linha:https://hdl.handle.net/20.500.14352/133687
Access Level:acceso abierto
Palavra-chave:636.08
Morbillivirus
IL-10
Immunosuppression
Dendritic cells
Goats
Producción animal
3104 Producción Animal
id ES_b2bc934741aafa507e904997d53e5ed5
oai_identifier_str oai:docta.ucm.es:20.500.14352/133687
network_acronym_str ES
network_name_str España
repository_id_str
spelling Peste des petits ruminants virus (PPRV) modulates caprine dendritic cell function and induces immunosuppression through IL-10 upregulationNogales-Altozano, PabloMartínez Rodrigo, AbelRojas, José MSevilla, Noemí636.08MorbillivirusIL-10ImmunosuppressionDendritic cellsGoatsProducción animal3104 Producción AnimalPeste des petits ruminants (PPR) is a WOAH notifiable disease affecting sheep and goats, caused by Peste des petits ruminants virus (PPRV), a morbillivirus of the Paramyxoviridae family. Infection with PPRV leads to immunosuppression, creating conditions for opportunistic infections that can result in animal mortality. Although goats generally exhibit more severe clinical signs than sheep, the underlying mechanisms driving this species-specific difference remain poorly understood. Dendritic cells (DC), which play a pivotal role in initiating immune responses, are among the immune targets of PPRV in small ruminants. In this study, we examined the impact of PPRV on caprine immune cells, focusing on CD14+ monocytes and monocyte-derived dendritic cells (MoDC). Our findings indicate that PPRV infects goat monocytes without preventing their differentiation into DC. Infected MoDC displayed increased expression of maturation markers and reduced phagocytic activity, suggesting a transition toward an activated phenotype. However, mixed lymphocyte reaction assays revealed that PPRV-infected MoDCs have a diminished capacity to promote T cell proliferation. This impaired function was associated with elevated IL-10 production and reduced conjugation between DCs and T cells. Overall, PPRV infection induces an atypical maturation stage in goat MoDCs, characterized by partial activation but impaired antigen presentation. These findings demonstrate that PPRV-driven modulation of DC function contributes to the immunosuppression observed during PPRV infection in goats.Taylor & FrancisUniversidad Complutense de Madrid20262026-01-0120262026-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/133687reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1336872026-06-02T12:44:21Z
dc.title.none.fl_str_mv Peste des petits ruminants virus (PPRV) modulates caprine dendritic cell function and induces immunosuppression through IL-10 upregulation
title Peste des petits ruminants virus (PPRV) modulates caprine dendritic cell function and induces immunosuppression through IL-10 upregulation
spellingShingle Peste des petits ruminants virus (PPRV) modulates caprine dendritic cell function and induces immunosuppression through IL-10 upregulation
Nogales-Altozano, Pablo
636.08
Morbillivirus
IL-10
Immunosuppression
Dendritic cells
Goats
Producción animal
3104 Producción Animal
title_short Peste des petits ruminants virus (PPRV) modulates caprine dendritic cell function and induces immunosuppression through IL-10 upregulation
title_full Peste des petits ruminants virus (PPRV) modulates caprine dendritic cell function and induces immunosuppression through IL-10 upregulation
title_fullStr Peste des petits ruminants virus (PPRV) modulates caprine dendritic cell function and induces immunosuppression through IL-10 upregulation
title_full_unstemmed Peste des petits ruminants virus (PPRV) modulates caprine dendritic cell function and induces immunosuppression through IL-10 upregulation
title_sort Peste des petits ruminants virus (PPRV) modulates caprine dendritic cell function and induces immunosuppression through IL-10 upregulation
dc.creator.none.fl_str_mv Nogales-Altozano, Pablo
Martínez Rodrigo, Abel
Rojas, José M
Sevilla, Noemí
author Nogales-Altozano, Pablo
author_facet Nogales-Altozano, Pablo
Martínez Rodrigo, Abel
Rojas, José M
Sevilla, Noemí
author_role author
author2 Martínez Rodrigo, Abel
Rojas, José M
Sevilla, Noemí
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 636.08
Morbillivirus
IL-10
Immunosuppression
Dendritic cells
Goats
Producción animal
3104 Producción Animal
topic 636.08
Morbillivirus
IL-10
Immunosuppression
Dendritic cells
Goats
Producción animal
3104 Producción Animal
description Peste des petits ruminants (PPR) is a WOAH notifiable disease affecting sheep and goats, caused by Peste des petits ruminants virus (PPRV), a morbillivirus of the Paramyxoviridae family. Infection with PPRV leads to immunosuppression, creating conditions for opportunistic infections that can result in animal mortality. Although goats generally exhibit more severe clinical signs than sheep, the underlying mechanisms driving this species-specific difference remain poorly understood. Dendritic cells (DC), which play a pivotal role in initiating immune responses, are among the immune targets of PPRV in small ruminants. In this study, we examined the impact of PPRV on caprine immune cells, focusing on CD14+ monocytes and monocyte-derived dendritic cells (MoDC). Our findings indicate that PPRV infects goat monocytes without preventing their differentiation into DC. Infected MoDC displayed increased expression of maturation markers and reduced phagocytic activity, suggesting a transition toward an activated phenotype. However, mixed lymphocyte reaction assays revealed that PPRV-infected MoDCs have a diminished capacity to promote T cell proliferation. This impaired function was associated with elevated IL-10 production and reduced conjugation between DCs and T cells. Overall, PPRV infection induces an atypical maturation stage in goat MoDCs, characterized by partial activation but impaired antigen presentation. These findings demonstrate that PPRV-driven modulation of DC function contributes to the immunosuppression observed during PPRV infection in goats.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026-01-01
2026
2026-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/133687
url https://hdl.handle.net/20.500.14352/133687
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869417080337465344
score 15,228081

Registos relacionados