Regional inequalities in heart failure hospitalisation and in-hospital mortality in Spain (2016-2022): a nationwide, observational study

Background Heart failure remains one of the leading causes of hospital admissions and mortality worldwide, with substantial regional disparities in clinical outcomes. These variations have been linked to differences in socioeconomic conditions, health determinants, and health-care system organisatio...

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Detalles Bibliográficos
Autores: Ortiz-Cortés, C, Fernández-Friera, L, Gámez, JM, Fillat, AC, Lozano, CB, Sambola, A, Rubio, LF, Padial, LR, Ruiz, RC, Pérez, MP, Hernández, JMD, Rosillo, N, Fernández, SS, del Prado, N, Bernal, JL, Pérez, CF, Alvaredo, D, Rico-Martíin, S, Elola-Somozar, FJ
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p20610
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/20610
Access Level:acceso abierto
Palabra clave:Heart failure
Hospitalisation
In-hospital mortality
Regional disparities
Socioeconomic factors
Health determinants
Descripción
Sumario:Background Heart failure remains one of the leading causes of hospital admissions and mortality worldwide, with substantial regional disparities in clinical outcomes. These variations have been linked to differences in socioeconomic conditions, health determinants, and health-care system organisation. The aim of this study was to analyse regional differences in hospitalisation rates and in-hospital mortality for heart failure across Spain's autonomous communities, and to examine their associations with hospital characteristics and regional health determinants. Methods We conducted a nationwide, retrospective, population-based study using Spain's national hospital discharge database (Conjunto M & iacute;nimo B & aacute;sico de Datos, CMBD) to identify adults (>= 18 years) discharged from public general hospitals within the Spanish National Health System (SNS) with a primary diagnosis of heart failure from January 1, 2016, to December 31, 2022. Differences in hospitalisation rates and risk-standardised in-hospital mortality between autonomous communities were analysed, along with associations with hospital characteristics and regional health determinants.<br /> Findings A total of 764,083 hospitalisations for heart failure were analysed. The mean age of participants was 80.8 +/- 10.6 years. The age-and sex-standardised hospitalisation rate was 255 per 100,000 inhabitants, with significant differences between autonomous communities. Crude in-hospital mortality rate was 11.3% (86,426 episodes), with substantial regional variation in risk-standardised mortality rate (ranged from 7.7% to 16.4%) No associations were found between hospital characteristics and risk-standardised mortality rate at the regional level. Regional health determinants were highly collinear; among all determinants assessed, per-capita gross domestic product was independently associated with lower risk-standardised mortality (beta GDPpc = -0.77; 95% CI: -1.04 to-0.49; p < 0.001; R2 = 0.77). Interpretation Significant regional differences in hospitalisation rates and risk-standardised mortality rates were observed among patients hospitalised for heart failure. Regional disparities in gross domestic product per capita may partly explain these differences. These results have clinical and policy implications, underscoring the need to consider socioeconomic determinants when analysing health outcomes and designing public policies aimed at reducing health inequalities. Our findings might be relevant to other European countries with similar public health systems.