Memory deficits in children and adolescents with a psychotic disorder: a systematic review and meta-analysis

Early-onset psychosis (EOP) is a severe disorder which takes place before 18 years. It entails diverse clinical and functional implications, and it may lead to critical impairments in neurocognitive functions. Although deficits in memory are well described in adult populations and they appear to be...

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Detalhes bibliográficos
Autores: de-la-Higuera-Gonzalez, Pilar, Rodríguez Toscano, Elisa, Diaz-Carracedo, Patricia, Gonzalez-Urrea, Maria Juliana, Padilla-Quiles, Geraldine, Díaz Marsa, Marina Francisca, De La-Torre Luque, Alejandro Francisco
Formato: artículo
Fecha de publicación:2025
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/131267
Acesso em linha:https://hdl.handle.net/20.500.14352/131267
Access Level:acceso abierto
Palavra-chave:Psiquiatría
3211 Psiquiatría
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spelling Memory deficits in children and adolescents with a psychotic disorder: a systematic review and meta-analysisde-la-Higuera-Gonzalez, PilarRodríguez Toscano, ElisaDiaz-Carracedo, PatriciaGonzalez-Urrea, Maria JulianaPadilla-Quiles, GeraldineDíaz Marsa, Marina FranciscaDe La-Torre Luque, Alejandro FranciscoPsiquiatría3211 PsiquiatríaEarly-onset psychosis (EOP) is a severe disorder which takes place before 18 years. It entails diverse clinical and functional implications, and it may lead to critical impairments in neurocognitive functions. Although deficits in memory are well described in adult populations and they appear to be clinically related with psychosis, impairments in memory in EOP show inconsistencies between studies. This study aimed to gain insight into the relationship between EOP and memory impairments, studying the potential contribution of moderators (storage source and memory content) on the observed memory deficits. This systematic review and meta-analysis was conducted following the PRISMA-2020 guidelines. Search was conducted in English and Spanish in five databases. Case–control studies which met all requirements were selected. Overall effect size was calculated under the random-effects model and Z-based tests were used. Heterogeneity was analysed by the I2 statistic. Mixed-effects meta-regression analysis was used to study the influence of methodological quality of studies, mean age, proportion of female participants within sample, mean diagnosis, memory storage type, memory content as moderators on individual effect size variability. As a result, 32 articles were finally selected, pooling data from 2636 participants (49.29% EOP participants). Overall effect size was Hedges’ g = – 1.01, CI95 = [ – 1.35, – 0.67], p <.01, indicating lower memory performance in the EOP group in comparison to healthy controls. Diagnosis and memory storage were found as significant moderators in the memory performance variance: larger deficits were found in children with psychosis and in working memory tasks.SpringerUniversidad Complutense de Madrid20252025-02-0420252025-02-04journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/131267reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1312672026-06-02T12:44:21Z
dc.title.none.fl_str_mv Memory deficits in children and adolescents with a psychotic disorder: a systematic review and meta-analysis
title Memory deficits in children and adolescents with a psychotic disorder: a systematic review and meta-analysis
spellingShingle Memory deficits in children and adolescents with a psychotic disorder: a systematic review and meta-analysis
de-la-Higuera-Gonzalez, Pilar
Psiquiatría
3211 Psiquiatría
title_short Memory deficits in children and adolescents with a psychotic disorder: a systematic review and meta-analysis
title_full Memory deficits in children and adolescents with a psychotic disorder: a systematic review and meta-analysis
title_fullStr Memory deficits in children and adolescents with a psychotic disorder: a systematic review and meta-analysis
title_full_unstemmed Memory deficits in children and adolescents with a psychotic disorder: a systematic review and meta-analysis
title_sort Memory deficits in children and adolescents with a psychotic disorder: a systematic review and meta-analysis
dc.creator.none.fl_str_mv de-la-Higuera-Gonzalez, Pilar
Rodríguez Toscano, Elisa
Diaz-Carracedo, Patricia
Gonzalez-Urrea, Maria Juliana
Padilla-Quiles, Geraldine
Díaz Marsa, Marina Francisca
De La-Torre Luque, Alejandro Francisco
author de-la-Higuera-Gonzalez, Pilar
author_facet de-la-Higuera-Gonzalez, Pilar
Rodríguez Toscano, Elisa
Diaz-Carracedo, Patricia
Gonzalez-Urrea, Maria Juliana
Padilla-Quiles, Geraldine
Díaz Marsa, Marina Francisca
De La-Torre Luque, Alejandro Francisco
author_role author
author2 Rodríguez Toscano, Elisa
Diaz-Carracedo, Patricia
Gonzalez-Urrea, Maria Juliana
Padilla-Quiles, Geraldine
Díaz Marsa, Marina Francisca
De La-Torre Luque, Alejandro Francisco
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Psiquiatría
3211 Psiquiatría
topic Psiquiatría
3211 Psiquiatría
description Early-onset psychosis (EOP) is a severe disorder which takes place before 18 years. It entails diverse clinical and functional implications, and it may lead to critical impairments in neurocognitive functions. Although deficits in memory are well described in adult populations and they appear to be clinically related with psychosis, impairments in memory in EOP show inconsistencies between studies. This study aimed to gain insight into the relationship between EOP and memory impairments, studying the potential contribution of moderators (storage source and memory content) on the observed memory deficits. This systematic review and meta-analysis was conducted following the PRISMA-2020 guidelines. Search was conducted in English and Spanish in five databases. Case–control studies which met all requirements were selected. Overall effect size was calculated under the random-effects model and Z-based tests were used. Heterogeneity was analysed by the I2 statistic. Mixed-effects meta-regression analysis was used to study the influence of methodological quality of studies, mean age, proportion of female participants within sample, mean diagnosis, memory storage type, memory content as moderators on individual effect size variability. As a result, 32 articles were finally selected, pooling data from 2636 participants (49.29% EOP participants). Overall effect size was Hedges’ g = – 1.01, CI95 = [ – 1.35, – 0.67], p <.01, indicating lower memory performance in the EOP group in comparison to healthy controls. Diagnosis and memory storage were found as significant moderators in the memory performance variance: larger deficits were found in children with psychosis and in working memory tasks.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-02-04
2025
2025-02-04
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/131267
url https://hdl.handle.net/20.500.14352/131267
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,228081

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