Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study
BackgroundChildhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been explored. The aim of this study is to examine whether cannabis use...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Recursos: | INCLIVA |
| Repositorio: | r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
| OAI Identifier: | oai:incliva.fundanetsuite.com:p17985 |
| Acesso em linha: | https://incliva.portalinvestigacion.com/publicaciones/17985 |
| Access Level: | acceso abierto |
| Palavra-chave: | Cannabis use childhood experience mediation psychotic disorders trauma |
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Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control studyTrotta, GRodriguez, VQuattrone, DSpinazzola, ETripoli, GGayer-Anderson, CFreeman, TPJongsma, HESideli, LAas, MStilo, SALa Cascia, CFerraro, LLa Barbera, DLasalvia, ATosato, STarricone, ID'Andrea, GTortelli, ASchürhoff, FSzöke, APignon, BSelten, JPVelthorst, Ede Haan, LLlorca, PMMenezes, PRDel Ben, CMSantos, JLArrojo, MBobes, JSanjuán, JBernardo, MArango, CKirkbride, JBJones, PBRichards, ARutten, BPVan Os, JAustin-Zimmerman, ILi, ZKMorgan, CSham, PCVassos, EWong, CBentall, RFisher, HLMurray, RMAlameda, LDi Forti, MCannabis usechildhood experiencemediationpsychotic disorderstraumaBackgroundChildhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been explored. The aim of this study is to examine whether cannabis use mediates the relationship between childhood adversity and psychosis. MethodsData were utilised on 881 first-episode psychosis patients and 1231 controls from the European network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Detailed history of cannabis use was collected with the Cannabis Experience Questionnaire. The Childhood Experience of Care and Abuse Questionnaire was used to assess exposure to household discord, sexual, physical or emotional abuse and bullying in two periods: early (0-11 years), and late (12-17 years). A path decomposition method was used to analyse whether the association between childhood adversity and psychosis was mediated by (1) lifetime cannabis use, (2) cannabis potency and (3) frequency of use. ResultsThe association between household discord and psychosis was partially mediated by lifetime use of cannabis (indirect effect coef. 0.078, s.e. 0.022, 17%), its potency (indirect effect coef. 0.059, s.e. 0.018, 14%) and by frequency (indirect effect coef. 0.117, s.e. 0.038, 29%). Similar findings were obtained when analyses were restricted to early exposure to household discord. ConclusionsHarmful patterns of cannabis use mediated the association between specific childhood adversities, like household discord, with later psychosis. Children exposed to particularly challenging environments in their household could benefit from psychosocial interventions aimed at preventing cannabis misuse.CAMBRIDGE UNIV PRESS2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/17985PSYCHOLOGICAL MEDICINEISSN: 00332917ISSNe: 14698978reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p179852026-06-07T16:35:31Z |
| dc.title.none.fl_str_mv |
Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study |
| title |
Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study |
| spellingShingle |
Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study Trotta, G Cannabis use childhood experience mediation psychotic disorders trauma |
| title_short |
Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study |
| title_full |
Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study |
| title_fullStr |
Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study |
| title_full_unstemmed |
Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study |
| title_sort |
Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study |
| dc.creator.none.fl_str_mv |
Trotta, G Rodriguez, V Quattrone, D Spinazzola, E Tripoli, G Gayer-Anderson, C Freeman, TP Jongsma, HE Sideli, L Aas, M Stilo, SA La Cascia, C Ferraro, L La Barbera, D Lasalvia, A Tosato, S Tarricone, I D'Andrea, G Tortelli, A Schürhoff, F Szöke, A Pignon, B Selten, JP Velthorst, E de Haan, L Llorca, PM Menezes, PR Del Ben, CM Santos, JL Arrojo, M Bobes, J Sanjuán, J Bernardo, M Arango, C Kirkbride, JB Jones, PB Richards, A Rutten, BP Van Os, J Austin-Zimmerman, I Li, ZK Morgan, C Sham, PC Vassos, E Wong, C Bentall, R Fisher, HL Murray, RM Alameda, L Di Forti, M |
| author |
Trotta, G |
| author_facet |
Trotta, G Rodriguez, V Quattrone, D Spinazzola, E Tripoli, G Gayer-Anderson, C Freeman, TP Jongsma, HE Sideli, L Aas, M Stilo, SA La Cascia, C Ferraro, L La Barbera, D Lasalvia, A Tosato, S Tarricone, I D'Andrea, G Tortelli, A Schürhoff, F Szöke, A Pignon, B Selten, JP Velthorst, E de Haan, L Llorca, PM Menezes, PR Del Ben, CM Santos, JL Arrojo, M Bobes, J Sanjuán, J Bernardo, M Arango, C Kirkbride, JB Jones, PB Richards, A Rutten, BP Van Os, J Austin-Zimmerman, I Li, ZK Morgan, C Sham, PC Vassos, E Wong, C Bentall, R Fisher, HL Murray, RM Alameda, L Di Forti, M |
| author_role |
author |
| author2 |
Rodriguez, V Quattrone, D Spinazzola, E Tripoli, G Gayer-Anderson, C Freeman, TP Jongsma, HE Sideli, L Aas, M Stilo, SA La Cascia, C Ferraro, L La Barbera, D Lasalvia, A Tosato, S Tarricone, I D'Andrea, G Tortelli, A Schürhoff, F Szöke, A Pignon, B Selten, JP Velthorst, E de Haan, L Llorca, PM Menezes, PR Del Ben, CM Santos, JL Arrojo, M Bobes, J Sanjuán, J Bernardo, M Arango, C Kirkbride, JB Jones, PB Richards, A Rutten, BP Van Os, J Austin-Zimmerman, I Li, ZK Morgan, C Sham, PC Vassos, E Wong, C Bentall, R Fisher, HL Murray, RM Alameda, L Di Forti, M |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Cannabis use childhood experience mediation psychotic disorders trauma |
| topic |
Cannabis use childhood experience mediation psychotic disorders trauma |
| description |
BackgroundChildhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been explored. The aim of this study is to examine whether cannabis use mediates the relationship between childhood adversity and psychosis. MethodsData were utilised on 881 first-episode psychosis patients and 1231 controls from the European network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Detailed history of cannabis use was collected with the Cannabis Experience Questionnaire. The Childhood Experience of Care and Abuse Questionnaire was used to assess exposure to household discord, sexual, physical or emotional abuse and bullying in two periods: early (0-11 years), and late (12-17 years). A path decomposition method was used to analyse whether the association between childhood adversity and psychosis was mediated by (1) lifetime cannabis use, (2) cannabis potency and (3) frequency of use. ResultsThe association between household discord and psychosis was partially mediated by lifetime use of cannabis (indirect effect coef. 0.078, s.e. 0.022, 17%), its potency (indirect effect coef. 0.059, s.e. 0.018, 14%) and by frequency (indirect effect coef. 0.117, s.e. 0.038, 29%). Similar findings were obtained when analyses were restricted to early exposure to household discord. ConclusionsHarmful patterns of cannabis use mediated the association between specific childhood adversities, like household discord, with later psychosis. Children exposed to particularly challenging environments in their household could benefit from psychosocial interventions aimed at preventing cannabis misuse. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://incliva.portalinvestigacion.com/publicaciones/17985 |
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https://incliva.portalinvestigacion.com/publicaciones/17985 |
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Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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CAMBRIDGE UNIV PRESS |
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CAMBRIDGE UNIV PRESS |
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PSYCHOLOGICAL MEDICINE ISSN: 00332917 ISSNe: 14698978 reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname:INCLIVA |
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INCLIVA |
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r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
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r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
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