Cellular stress responses as modulators of drug cytotoxicity in pharmacotherapy of glioblastoma

Despite the extensive efforts to find effective therapeutic strategies, glioblastoma (GBM) remains a therapeutic challenge with dismal prognosis of survival. Over the last decade the role of stress responses in GBM therapy has gained a great deal of attention, since depending on the duration and int...

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Detalhes bibliográficos
Autores: Kusaczuk, Magdalena, Tovar Ambel, Elena, Naumowicz, Monika, Velasco Díez, Guillermo
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/119840
Acesso em linha:https://hdl.handle.net/20.500.14352/119840
Access Level:acceso abierto
Palavra-chave:616-006.04
616-006.04-085
577.1
615.01/.03
Glioblastoma
Autophagy
ER stress
Oxidative stress
Pharmacotherapy
Oncología
Bioquímica (Biología)
Farmacología (Farmacia)
3201.01 Oncología
2403 Bioquímica
3209 Farmacología
id ES_ac9e57d28dcf0b8c8b34a5182c5b84fe
oai_identifier_str oai:docta.ucm.es:20.500.14352/119840
network_acronym_str ES
network_name_str España
repository_id_str
spelling Cellular stress responses as modulators of drug cytotoxicity in pharmacotherapy of glioblastomaKusaczuk, MagdalenaTovar Ambel, ElenaNaumowicz, MonikaVelasco Díez, Guillermo616-006.04616-006.04-085577.1615.01/.03GlioblastomaAutophagyER stressOxidative stressPharmacotherapyOncologíaBioquímica (Biología)Farmacología (Farmacia)3201.01 Oncología2403 Bioquímica3209 FarmacologíaDespite the extensive efforts to find effective therapeutic strategies, glioblastoma (GBM) remains a therapeutic challenge with dismal prognosis of survival. Over the last decade the role of stress responses in GBM therapy has gained a great deal of attention, since depending on the duration and intensity of these cellular programs they can be cytoprotective or promote cancer cell death. As such, initiation of the UPR, autophagy or oxidative stress may either impede or facilitate drug-mediated cell killing. In this review, we summarize the mechanisms that regulate ER stress, autophagy, and oxidative stress during GBM development and progression to later discuss the involvement of these stress pathways in the response to different treatments. We also discuss how a precise understanding of the molecular mechanisms regulating stress responses evoked by different pharmacological agents could decisively contribute to the design of novel and more effective combinational treatments against brain malignancies.ElsevierUniversidad Complutense de Madrid20242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/119840reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengMinisterio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PI18%2F00442MICIU Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PI21%2F00343 ALK Y LA UTILIZACIÓN DE CANNABINOIDESopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1198402026-06-02T12:44:21Z
dc.title.none.fl_str_mv Cellular stress responses as modulators of drug cytotoxicity in pharmacotherapy of glioblastoma
title Cellular stress responses as modulators of drug cytotoxicity in pharmacotherapy of glioblastoma
spellingShingle Cellular stress responses as modulators of drug cytotoxicity in pharmacotherapy of glioblastoma
Kusaczuk, Magdalena
616-006.04
616-006.04-085
577.1
615.01/.03
Glioblastoma
Autophagy
ER stress
Oxidative stress
Pharmacotherapy
Oncología
Bioquímica (Biología)
Farmacología (Farmacia)
3201.01 Oncología
2403 Bioquímica
3209 Farmacología
title_short Cellular stress responses as modulators of drug cytotoxicity in pharmacotherapy of glioblastoma
title_full Cellular stress responses as modulators of drug cytotoxicity in pharmacotherapy of glioblastoma
title_fullStr Cellular stress responses as modulators of drug cytotoxicity in pharmacotherapy of glioblastoma
title_full_unstemmed Cellular stress responses as modulators of drug cytotoxicity in pharmacotherapy of glioblastoma
title_sort Cellular stress responses as modulators of drug cytotoxicity in pharmacotherapy of glioblastoma
dc.creator.none.fl_str_mv Kusaczuk, Magdalena
Tovar Ambel, Elena
Naumowicz, Monika
Velasco Díez, Guillermo
author Kusaczuk, Magdalena
author_facet Kusaczuk, Magdalena
Tovar Ambel, Elena
Naumowicz, Monika
Velasco Díez, Guillermo
author_role author
author2 Tovar Ambel, Elena
Naumowicz, Monika
Velasco Díez, Guillermo
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616-006.04
616-006.04-085
577.1
615.01/.03
Glioblastoma
Autophagy
ER stress
Oxidative stress
Pharmacotherapy
Oncología
Bioquímica (Biología)
Farmacología (Farmacia)
3201.01 Oncología
2403 Bioquímica
3209 Farmacología
topic 616-006.04
616-006.04-085
577.1
615.01/.03
Glioblastoma
Autophagy
ER stress
Oxidative stress
Pharmacotherapy
Oncología
Bioquímica (Biología)
Farmacología (Farmacia)
3201.01 Oncología
2403 Bioquímica
3209 Farmacología
description Despite the extensive efforts to find effective therapeutic strategies, glioblastoma (GBM) remains a therapeutic challenge with dismal prognosis of survival. Over the last decade the role of stress responses in GBM therapy has gained a great deal of attention, since depending on the duration and intensity of these cellular programs they can be cytoprotective or promote cancer cell death. As such, initiation of the UPR, autophagy or oxidative stress may either impede or facilitate drug-mediated cell killing. In this review, we summarize the mechanisms that regulate ER stress, autophagy, and oxidative stress during GBM development and progression to later discuss the involvement of these stress pathways in the response to different treatments. We also discuss how a precise understanding of the molecular mechanisms regulating stress responses evoked by different pharmacological agents could decisively contribute to the design of novel and more effective combinational treatments against brain malignancies.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/119840
url https://hdl.handle.net/20.500.14352/119840
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PI18%2F00442
MICIU Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PI21%2F00343 ALK Y LA UTILIZACIÓN DE CANNABINOIDES
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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