Dexketoprofen Trometamol and Tramadol Hydrochloride Fixed-Dose Combination in Moderate to Severe Acute Low Back Pain

Introduction: Dexketoprofen/tramadol 25/75 mg (DKP/TRAM) is a fixed-dose combination of a cyclooxygenase inhibitor and opioid receptor agonist. To better understand the efficacy and safety of DKP/TRAM in the treatment of moderate to severe acute lower back pain (LBP) with or without radiculopathy, w...

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Detalles Bibliográficos
Autores: Varrassi, G.|||0000-0002-3822-2923, Hanna, M., Coaccioli, S., Fabrizzi, P., Baldini, S., Kruljac, I., Brotons, Carlos|||0000-0001-9388-6581, Perrot, S.
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:308078
Acceso en línea:https://ddd.uab.cat/record/308078
https://dx.doi.org/urn:doi:10.1007/s40122-024-00623-4
Access Level:acceso abierto
Palabra clave:Acute low back pain
Clinical trial
Dexketoprofen trometamol
Fixed-dose combination
Tramadol hydrochloride
Descripción
Sumario:Introduction: Dexketoprofen/tramadol 25/75 mg (DKP/TRAM) is a fixed-dose combination of a cyclooxygenase inhibitor and opioid receptor agonist. To better understand the efficacy and safety of DKP/TRAM in the treatment of moderate to severe acute lower back pain (LBP) with or without radiculopathy, we carried out a large explorative phase IV international, multicenter, prospective, randomized, double-blind, parallel group, placebo-controlled study (DANTE). Methods: A total of 538 patients with or without a history of LBP and experiencing acute LPB of moderate to severe intensity [Numerical Rating Scale-Pain Intensity (NRS-PI) score.

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