International survey of treatment practices for atopic dermatitis in pregnant and breastfeeding women: physician perspectives

Background and Objectives: Systemic treatment of pregnant/breastfeeding atopic dermatitis (AD) patients is challenging due to limited safety data. We explored treatment practices with systemic agents, including the guideline-recommended cyclosporine as the first systemic choice as well as emerging t...

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Autores: Pereira, Manuel P., Giménez Arnau, Anna Maria, Zuberbier, Torsten
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:dnet:recercat____::64e296d55e51175da71a3e97bfd5e9d6
Acesso em linha:https://hdl.handle.net/10230/73301
http://dx.doi.org/10.1111/ddg.15728
Access Level:acceso abierto
Palavra-chave:Atopic dermatitis
Breastfeeding
Pregnancy
Survey
Systemic treatment
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spelling International survey of treatment practices for atopic dermatitis in pregnant and breastfeeding women: physician perspectivesPereira, Manuel P.Giménez Arnau, Anna MariaZuberbier, TorstenAtopic dermatitisBreastfeedingPregnancySurveySystemic treatmentBackground and Objectives: Systemic treatment of pregnant/breastfeeding atopic dermatitis (AD) patients is challenging due to limited safety data. We explored treatment practices with systemic agents, including the guideline-recommended cyclosporine as the first systemic choice as well as emerging therapies, in this vulnerable population. Patients and Methods: The Global Allergy and Asthma Excellence Network (GALEN) ADCARE initiative collected data from physicians worldwide who treat pregnant women with AD. Physicians completed an electronic questionnaire on the use of systemic agents in pregnant/breastfeeding AD patients. Results: 103 physicians from 32 countries completed the survey, primarily dermatologists (n = 48) or allergologists (n = 43). Antihistamines were the systemic drug most often considered to be used during pregnancy/breastfeeding (n = 73/81, 90.1%), with fewer physicians considering the use of systemic agents for the first trimester compared to later stages of pregnancy. For acute flares, systemic corticosteroids (n = 34/80, 42.5%) were preferred, followed by biologics and antihistamines (each n = 15/80, 18.8%). Although the guideline-recommended cyclosporine is sometimes considered for AD during pregnancy (n = 38/81, 46.9%), it was rarely considered as the preferred drug by physicians (n = 1/80, 1.25%). Conclusions: Our study shows a misalignment between guideline recommendations and prescription patterns and highlights an unmet need for knowing and using the existing recommendations.Wiley2026202620252026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10230/73301http://dx.doi.org/10.1111/ddg.15728https://hdl.handle.net/10230/73301reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJDDG - Journal of the German Society of Dermatology. 2025;23(9):1116-24© 2025 The Author(s). Journal der Deutschen Dermatologischen Gesellschaft published by John Wiley & Sons Ltd on behalf of Deutsche Dermatologische Gesellschaft. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:recercat____::64e296d55e51175da71a3e97bfd5e9d62026-05-29T05:05:01Z
dc.title.none.fl_str_mv International survey of treatment practices for atopic dermatitis in pregnant and breastfeeding women: physician perspectives
title International survey of treatment practices for atopic dermatitis in pregnant and breastfeeding women: physician perspectives
spellingShingle International survey of treatment practices for atopic dermatitis in pregnant and breastfeeding women: physician perspectives
Pereira, Manuel P.
Atopic dermatitis
Breastfeeding
Pregnancy
Survey
Systemic treatment
title_short International survey of treatment practices for atopic dermatitis in pregnant and breastfeeding women: physician perspectives
title_full International survey of treatment practices for atopic dermatitis in pregnant and breastfeeding women: physician perspectives
title_fullStr International survey of treatment practices for atopic dermatitis in pregnant and breastfeeding women: physician perspectives
title_full_unstemmed International survey of treatment practices for atopic dermatitis in pregnant and breastfeeding women: physician perspectives
title_sort International survey of treatment practices for atopic dermatitis in pregnant and breastfeeding women: physician perspectives
dc.creator.none.fl_str_mv Pereira, Manuel P.
Giménez Arnau, Anna Maria
Zuberbier, Torsten
author Pereira, Manuel P.
author_facet Pereira, Manuel P.
Giménez Arnau, Anna Maria
Zuberbier, Torsten
author_role author
author2 Giménez Arnau, Anna Maria
Zuberbier, Torsten
author2_role author
author
dc.subject.none.fl_str_mv Atopic dermatitis
Breastfeeding
Pregnancy
Survey
Systemic treatment
topic Atopic dermatitis
Breastfeeding
Pregnancy
Survey
Systemic treatment
description Background and Objectives: Systemic treatment of pregnant/breastfeeding atopic dermatitis (AD) patients is challenging due to limited safety data. We explored treatment practices with systemic agents, including the guideline-recommended cyclosporine as the first systemic choice as well as emerging therapies, in this vulnerable population. Patients and Methods: The Global Allergy and Asthma Excellence Network (GALEN) ADCARE initiative collected data from physicians worldwide who treat pregnant women with AD. Physicians completed an electronic questionnaire on the use of systemic agents in pregnant/breastfeeding AD patients. Results: 103 physicians from 32 countries completed the survey, primarily dermatologists (n = 48) or allergologists (n = 43). Antihistamines were the systemic drug most often considered to be used during pregnancy/breastfeeding (n = 73/81, 90.1%), with fewer physicians considering the use of systemic agents for the first trimester compared to later stages of pregnancy. For acute flares, systemic corticosteroids (n = 34/80, 42.5%) were preferred, followed by biologics and antihistamines (each n = 15/80, 18.8%). Although the guideline-recommended cyclosporine is sometimes considered for AD during pregnancy (n = 38/81, 46.9%), it was rarely considered as the preferred drug by physicians (n = 1/80, 1.25%). Conclusions: Our study shows a misalignment between guideline recommendations and prescription patterns and highlights an unmet need for knowing and using the existing recommendations.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10230/73301
http://dx.doi.org/10.1111/ddg.15728
https://hdl.handle.net/10230/73301
url https://hdl.handle.net/10230/73301
http://dx.doi.org/10.1111/ddg.15728
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv JDDG - Journal of the German Society of Dermatology. 2025;23(9):1116-24
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,228081

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