Extremely high levels of vancomycin can cause severe renal toxicity

Vancomycin has usually been associated with nephrotoxicity. Generally, this toxicity is presented as proximal tubular cells injury with or without necrosis and as acute interstitial nephritis. However, development of both lesions is uncommonly described in literature. We present a case of vancomycin...

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Autores: Barceló-Vidal, Jaime, Rodríguez García, Eva, Grau Cerrato, Santiago
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/37244
Acceso en línea:http://hdl.handle.net/10230/37244
http://dx.doi.org/10.2147/IDR.S171669
Access Level:acceso abierto
Palabra clave:Ronyons -- Malalties
Nephrotoxicity
Therapeutic drug monitoring
Vancomycin
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spelling Extremely high levels of vancomycin can cause severe renal toxicityBarceló-Vidal, JaimeRodríguez García, EvaGrau Cerrato, SantiagoRonyons -- MalaltiesNephrotoxicityTherapeutic drug monitoringVancomycinVancomycin has usually been associated with nephrotoxicity. Generally, this toxicity is presented as proximal tubular cells injury with or without necrosis and as acute interstitial nephritis. However, development of both lesions is uncommonly described in literature. We present a case of vancomycin-induced nephrotoxicity resulting in both acute interstitial nephritis and tubular cells damage confirmed by renal biopsy. Peak and trough levels of 77.11 and 63.60 μg/mL, respectively, were obtained at the first plasma determination. After 8 more plasma determinations and several hemodialysis sessions, vancomycin levels were undetectable 1 month after therapy was stopped. To our knowledge, this is the case report with the highest vancomycin trough levels developing both lesions and describing total vancomycin washout after a biopsy-proven vancomycin toxicity. In conclusion, early vancomycin therapeutic drug monitoring should be performed in order to avoid toxicities where, as seen in our patient, antibiotic exposure could last around 1 month after last dose administration.Dove Medical Press201920192018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/37244http://dx.doi.org/10.2147/IDR.S171669reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésInfection and Drug Resistance. 2018 Jul 30;11:1027-30Copyright © 2018 Barceló-Vidal et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.http://creativecommons.org/licenses/by-nc/3.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/372442026-05-29T05:05:01Z
dc.title.none.fl_str_mv Extremely high levels of vancomycin can cause severe renal toxicity
title Extremely high levels of vancomycin can cause severe renal toxicity
spellingShingle Extremely high levels of vancomycin can cause severe renal toxicity
Barceló-Vidal, Jaime
Ronyons -- Malalties
Nephrotoxicity
Therapeutic drug monitoring
Vancomycin
title_short Extremely high levels of vancomycin can cause severe renal toxicity
title_full Extremely high levels of vancomycin can cause severe renal toxicity
title_fullStr Extremely high levels of vancomycin can cause severe renal toxicity
title_full_unstemmed Extremely high levels of vancomycin can cause severe renal toxicity
title_sort Extremely high levels of vancomycin can cause severe renal toxicity
dc.creator.none.fl_str_mv Barceló-Vidal, Jaime
Rodríguez García, Eva
Grau Cerrato, Santiago
author Barceló-Vidal, Jaime
author_facet Barceló-Vidal, Jaime
Rodríguez García, Eva
Grau Cerrato, Santiago
author_role author
author2 Rodríguez García, Eva
Grau Cerrato, Santiago
author2_role author
author
dc.subject.none.fl_str_mv Ronyons -- Malalties
Nephrotoxicity
Therapeutic drug monitoring
Vancomycin
topic Ronyons -- Malalties
Nephrotoxicity
Therapeutic drug monitoring
Vancomycin
description Vancomycin has usually been associated with nephrotoxicity. Generally, this toxicity is presented as proximal tubular cells injury with or without necrosis and as acute interstitial nephritis. However, development of both lesions is uncommonly described in literature. We present a case of vancomycin-induced nephrotoxicity resulting in both acute interstitial nephritis and tubular cells damage confirmed by renal biopsy. Peak and trough levels of 77.11 and 63.60 μg/mL, respectively, were obtained at the first plasma determination. After 8 more plasma determinations and several hemodialysis sessions, vancomycin levels were undetectable 1 month after therapy was stopped. To our knowledge, this is the case report with the highest vancomycin trough levels developing both lesions and describing total vancomycin washout after a biopsy-proven vancomycin toxicity. In conclusion, early vancomycin therapeutic drug monitoring should be performed in order to avoid toxicities where, as seen in our patient, antibiotic exposure could last around 1 month after last dose administration.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/37244
http://dx.doi.org/10.2147/IDR.S171669
url http://hdl.handle.net/10230/37244
http://dx.doi.org/10.2147/IDR.S171669
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Infection and Drug Resistance. 2018 Jul 30;11:1027-30
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc/3.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/3.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Dove Medical Press
publisher.none.fl_str_mv Dove Medical Press
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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