Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants

Objective: To investigate the specific and combined effects of personal concentrations of some per- and polyfluoroalkyl substances (PFAS), other persistent organic pollutants (POPs), and chemical elements -measured in individuals' blood several years before the pandemic- on the development of S...

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Detalhes bibliográficos
Autores: Pumarega, José Antonio|||0000-0001-6950-6702, Gasull, Magda|||0000-0003-4546-3650, Koponen, Jani, Campi, Laura, Rantakokko, Panu|||0000-0002-8624-1387, Henríquez-Hernández, Luis A., Aguilar, Ruth|||0000-0003-3277-3107, Donat-Vargas, Carolina, Zumbado, Manuel, Villar Garcia, Judit|||0000-0002-6767-3424, Rius i Gibert, Maria Cristina|||0000-0001-5189-6503, Santiago Díaz, Pablo|||0000-0003-2219-7687, Vidal, Marta, Jimenez, Alfons, Iglesias, Mar|||0000-0002-2274-4671, Dobaño Lazaro, Carlota|||0000-0002-6751-4060, Moncunill, Gemma|||0000-0001-5105-9836, Porta, Miquel|||0000-0003-1684-7428
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:304245
Acesso em linha:https://ddd.uab.cat/record/304245
https://dx.doi.org/urn:doi:10.1016/j.envres.2023.116965
Access Level:acceso abierto
Palavra-chave:Per- and polyfluoroalkyl substances (PFAS)
SARS-CoV-2
COVID-19
Mixtures
Immunotoxicity
Descrição
Resumo:Objective: To investigate the specific and combined effects of personal concentrations of some per- and polyfluoroalkyl substances (PFAS), other persistent organic pollutants (POPs), and chemical elements -measured in individuals' blood several years before the pandemic- on the development of SARS-CoV-2 infection and COVID-19 disease in the general population. Methods: We conducted a prospective cohort study in 240 individuals from the general population of Barcelona. PFAS, other POPs, and chemical elements were measured in plasma, serum, and whole blood samples, respectively, collected in 2016-2017. PFAS were analyzed by liquid chromatography-triple quadrupole mass spectrometry. SARS-CoV-2 infection was detected by rRT-PCR in nasopharyngeal swabs and/or antibody serology in blood samples collected in 2020-2021. Results: No individual PFAS nor their mixtures were significantly associated with SARS-CoV-2 seropositivity or COVID-19 disease. Previously identified mixtures of POPs and elements (Porta et al., 2023) remained significantly associated with seropositivity and COVID-19 when adjusted for PFAS (all OR.

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