Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors

Background: Humans are regularly exposed to metals and metalloids present in air, water, food, soil and domestic materials. Most of them can cross the placental barrier and cause adverse impacts on the developing foetus. Objectives: To describe the prenatal concentrations of metals and metalloids an...

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Autores: Lozano Relaño, Manuel, Murcia, Mario, Soler Blasco, Raquel, Casas Sanahuja, Maribel, Zubero, Begotxu, Riutort-Mayol, Gabriel, Gil, Fernando, Olmedo, Pablo, Grimalt Obrador, Joan, Amorós, Rubén, Lertxundi, Aitana, Vrijheid, Martine, Ballester Díez, Ferran, Llop, Sabrina
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/52940
Acesso em linha:http://hdl.handle.net/10230/52940
http://dx.doi.org/10.1016/j.chemosphere.2021.131809
Access Level:acceso abierto
Palavra-chave:Diet
Environmental exposure
Metalloids
Metals
Prenatal exposure
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spelling Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factorsLozano Relaño, ManuelMurcia, MarioSoler Blasco, RaquelCasas Sanahuja, MaribelZubero, BegotxuRiutort-Mayol, GabrielGil, FernandoOlmedo, PabloGrimalt Obrador, JoanAmorós, RubénLertxundi, AitanaVrijheid, MartineBallester Díez, FerranLlop, SabrinaDietEnvironmental exposureMetalloidsMetalsPrenatal exposureBackground: Humans are regularly exposed to metals and metalloids present in air, water, food, soil and domestic materials. Most of them can cross the placental barrier and cause adverse impacts on the developing foetus. Objectives: To describe the prenatal concentrations of metals and metalloids and to study the associated sociodemographic, environmental and dietary factors in pregnant Spanish women. Methods: Subjects were 1346 pregnant women of the INMA Project, for whom the following metals arsenic (As), cadmium (Cd), cobalt (Co), copper (Cu), molybdenum (Mo), nickel (Ni), lead (Pb), antimony (Sb), selenium (Se), thallium (Tl) and zinc (Zn) were determined in urine, at both the first and the third trimesters of gestation. Sociodemographic, dietary and environmental information was collected through questionnaires during pregnancy. Multiple linear mixed models were built in order to study the association between each metal and metalloid concentrations and the sociodemographic, environmental and dietary factors. Results: The most detected compounds were As, Co, Mo, Sb, Se and Zn at both trimesters. Zn was the element found in the highest concentrations at both trimesters and Tl was detected in the lowest concentrations. We observed significant associations between As, Cd, Cu, Sb, Tl and Zn concentrations and working situation, social class and age. Seafood, meat, fruits, nuts, vegetables and alcohol intake affected the levels of all the metals but Cd and Cu. Proximity to industrial areas, fields and air pollution were related to all metals except Cd, Sb and Se. Conclusions: This is the first large prospective longitudinal study on the exposure to metals and metalloids during pregnancy and associated factors to include several cohorts in Spain. The present study shows that some modifiable lifestyles, food intakes and environmental factors could be associated with prenatal exposure to metal(loid)s, which may be considered in further studies to assess their relationship with neonatal health outcomes.This study was funded by Grants from EU (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5–1); Spain: ISCIII (Red INMA G03/176, CB06/02/0041; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/0867, PI06/1213, PI07/0314, PI09/00090, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI13/02187, PI14/00891, PI14/01687, PI16/1288, PI17/00663, PI18/01142 and PI19/1338; Miguel Servet FEDER MS15/00025, MS20/0006, CPII16/00051, and FIS-FSE: 17/ 00260); CIBERESP; Generalitat Valenciana: FISABIO (UGP 15–230, UGP-15-244, and UGP-15-249), AICO/2020/285, and Alicia Koplowitz Foundation 2017; Generalitat de Catalunya-CIRIT 1999SGR 00241; Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065); Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221).Elsevier202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/52940http://dx.doi.org/10.1016/j.chemosphere.2021.131809reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésChemosphere. 2022 Jan;286(Pt 2):131809info:eu-repo/grantAgreement/EC/FP7/282957© 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/529402026-05-29T05:05:01Z
dc.title.none.fl_str_mv Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors
title Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors
spellingShingle Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors
Lozano Relaño, Manuel
Diet
Environmental exposure
Metalloids
Metals
Prenatal exposure
title_short Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors
title_full Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors
title_fullStr Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors
title_full_unstemmed Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors
title_sort Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors
dc.creator.none.fl_str_mv Lozano Relaño, Manuel
Murcia, Mario
Soler Blasco, Raquel
Casas Sanahuja, Maribel
Zubero, Begotxu
Riutort-Mayol, Gabriel
Gil, Fernando
Olmedo, Pablo
Grimalt Obrador, Joan
Amorós, Rubén
Lertxundi, Aitana
Vrijheid, Martine
Ballester Díez, Ferran
Llop, Sabrina
author Lozano Relaño, Manuel
author_facet Lozano Relaño, Manuel
Murcia, Mario
Soler Blasco, Raquel
Casas Sanahuja, Maribel
Zubero, Begotxu
Riutort-Mayol, Gabriel
Gil, Fernando
Olmedo, Pablo
Grimalt Obrador, Joan
Amorós, Rubén
Lertxundi, Aitana
Vrijheid, Martine
Ballester Díez, Ferran
Llop, Sabrina
author_role author
author2 Murcia, Mario
Soler Blasco, Raquel
Casas Sanahuja, Maribel
Zubero, Begotxu
Riutort-Mayol, Gabriel
Gil, Fernando
Olmedo, Pablo
Grimalt Obrador, Joan
Amorós, Rubén
Lertxundi, Aitana
Vrijheid, Martine
Ballester Díez, Ferran
Llop, Sabrina
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Diet
Environmental exposure
Metalloids
Metals
Prenatal exposure
topic Diet
Environmental exposure
Metalloids
Metals
Prenatal exposure
description Background: Humans are regularly exposed to metals and metalloids present in air, water, food, soil and domestic materials. Most of them can cross the placental barrier and cause adverse impacts on the developing foetus. Objectives: To describe the prenatal concentrations of metals and metalloids and to study the associated sociodemographic, environmental and dietary factors in pregnant Spanish women. Methods: Subjects were 1346 pregnant women of the INMA Project, for whom the following metals arsenic (As), cadmium (Cd), cobalt (Co), copper (Cu), molybdenum (Mo), nickel (Ni), lead (Pb), antimony (Sb), selenium (Se), thallium (Tl) and zinc (Zn) were determined in urine, at both the first and the third trimesters of gestation. Sociodemographic, dietary and environmental information was collected through questionnaires during pregnancy. Multiple linear mixed models were built in order to study the association between each metal and metalloid concentrations and the sociodemographic, environmental and dietary factors. Results: The most detected compounds were As, Co, Mo, Sb, Se and Zn at both trimesters. Zn was the element found in the highest concentrations at both trimesters and Tl was detected in the lowest concentrations. We observed significant associations between As, Cd, Cu, Sb, Tl and Zn concentrations and working situation, social class and age. Seafood, meat, fruits, nuts, vegetables and alcohol intake affected the levels of all the metals but Cd and Cu. Proximity to industrial areas, fields and air pollution were related to all metals except Cd, Sb and Se. Conclusions: This is the first large prospective longitudinal study on the exposure to metals and metalloids during pregnancy and associated factors to include several cohorts in Spain. The present study shows that some modifiable lifestyles, food intakes and environmental factors could be associated with prenatal exposure to metal(loid)s, which may be considered in further studies to assess their relationship with neonatal health outcomes.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/52940
http://dx.doi.org/10.1016/j.chemosphere.2021.131809
url http://hdl.handle.net/10230/52940
http://dx.doi.org/10.1016/j.chemosphere.2021.131809
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Chemosphere. 2022 Jan;286(Pt 2):131809
info:eu-repo/grantAgreement/EC/FP7/282957
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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