Design of active electrospun mats with single and core-shell structures to achieve different curcumin release kinetics

In this work, core-shell electrospun mats based on poly (lactic acid) (PLA) and polyvinyl alcohol (PVA) were developed as novel curcumin release materials. The effect of the incorporation of cellulose nanocrystals (CNN) in the PLA shell structure on structural, thermal and curcumin release were stud...

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Detalles Bibliográficos
Autores: Rojas, Adrián, Velásquez, Eliezer, Garrido, Luan, Galotto, María José, López de Dicastillo, Carol
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/376921
Acceso en línea:http://hdl.handle.net/10261/376921
https://api.elsevier.com/content/abstract/scopus_id/85078832022
Access Level:acceso abierto
Palabra clave:Cellulose nanocrystals
Coaxial electrospinning
Curcumin
Poly (lactic acid)
Polyvinyl alcohol
Release kinetic
curcumin
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spelling Design of active electrospun mats with single and core-shell structures to achieve different curcumin release kineticsRojas, AdriánVelásquez, EliezerGarrido, LuanGalotto, María JoséLópez de Dicastillo, CarolCellulose nanocrystalsCoaxial electrospinningCurcuminPoly (lactic acid)Polyvinyl alcoholRelease kineticcurcuminIn this work, core-shell electrospun mats based on poly (lactic acid) (PLA) and polyvinyl alcohol (PVA) were developed as novel curcumin release materials. The effect of the incorporation of cellulose nanocrystals (CNN) in the PLA shell structure on structural, thermal and curcumin release were studied. A phenomenological mass transfer model was used to correlate the experimental release kinetic data as well as the structural and thermal characterization of the electrospun mats. Curcumin distribution coefficients (KP/SA) values for core-shell electrospun PLA/PVA mats were higher than KP/SA values of uniaxial active PLA. Modelling analysis evidenced PLA/PVA coaxial structures slowed down the effective diffusion coefficients of curcumin, and this value notoriously decreased by the incorporation of CNC in the PLA shell matrix due to the tortuous path created through the PLA matrix.The authors acknowledge the financial support of CONICYT (Comisión Nacional de Investigación Científica y Tecnológica) through the Project Fondecyt Regular 1170624, CONICYT Fondecyt Postdoctoral Grant 3190929 and “Programa de Financiamiento Basal para Centros Científicos y Tecnológicos de Excelencia” Project FB0807.Peer reviewedElsevierComisión Nacional de Investigación Científica y Tecnológica (Chile)López de Dicastillo, Carol [0000-0003-0067-9765]202520252020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttp://hdl.handle.net/10261/376921https://api.elsevier.com/content/abstract/scopus_id/85078832022reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésJournal of Food Engineeringhttps://doi.org/10.1016/j.jfoodeng.2019.109900Noinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3769212026-05-22T06:33:51Z
dc.title.none.fl_str_mv Design of active electrospun mats with single and core-shell structures to achieve different curcumin release kinetics
title Design of active electrospun mats with single and core-shell structures to achieve different curcumin release kinetics
spellingShingle Design of active electrospun mats with single and core-shell structures to achieve different curcumin release kinetics
Rojas, Adrián
Cellulose nanocrystals
Coaxial electrospinning
Curcumin
Poly (lactic acid)
Polyvinyl alcohol
Release kinetic
curcumin
title_short Design of active electrospun mats with single and core-shell structures to achieve different curcumin release kinetics
title_full Design of active electrospun mats with single and core-shell structures to achieve different curcumin release kinetics
title_fullStr Design of active electrospun mats with single and core-shell structures to achieve different curcumin release kinetics
title_full_unstemmed Design of active electrospun mats with single and core-shell structures to achieve different curcumin release kinetics
title_sort Design of active electrospun mats with single and core-shell structures to achieve different curcumin release kinetics
dc.creator.none.fl_str_mv Rojas, Adrián
Velásquez, Eliezer
Garrido, Luan
Galotto, María José
López de Dicastillo, Carol
author Rojas, Adrián
author_facet Rojas, Adrián
Velásquez, Eliezer
Garrido, Luan
Galotto, María José
López de Dicastillo, Carol
author_role author
author2 Velásquez, Eliezer
Garrido, Luan
Galotto, María José
López de Dicastillo, Carol
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Comisión Nacional de Investigación Científica y Tecnológica (Chile)
López de Dicastillo, Carol [0000-0003-0067-9765]
dc.subject.none.fl_str_mv Cellulose nanocrystals
Coaxial electrospinning
Curcumin
Poly (lactic acid)
Polyvinyl alcohol
Release kinetic
curcumin
topic Cellulose nanocrystals
Coaxial electrospinning
Curcumin
Poly (lactic acid)
Polyvinyl alcohol
Release kinetic
curcumin
description In this work, core-shell electrospun mats based on poly (lactic acid) (PLA) and polyvinyl alcohol (PVA) were developed as novel curcumin release materials. The effect of the incorporation of cellulose nanocrystals (CNN) in the PLA shell structure on structural, thermal and curcumin release were studied. A phenomenological mass transfer model was used to correlate the experimental release kinetic data as well as the structural and thermal characterization of the electrospun mats. Curcumin distribution coefficients (KP/SA) values for core-shell electrospun PLA/PVA mats were higher than KP/SA values of uniaxial active PLA. Modelling analysis evidenced PLA/PVA coaxial structures slowed down the effective diffusion coefficients of curcumin, and this value notoriously decreased by the incorporation of CNC in the PLA shell matrix due to the tortuous path created through the PLA matrix.
publishDate 2020
dc.date.none.fl_str_mv 2020
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/376921
https://api.elsevier.com/content/abstract/scopus_id/85078832022
url http://hdl.handle.net/10261/376921
https://api.elsevier.com/content/abstract/scopus_id/85078832022
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Food Engineering
https://doi.org/10.1016/j.jfoodeng.2019.109900
No
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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