Management of a caseous lymphadenitis outbreak in a new Iberian ibex (Capra pyrenaica) stock reservoir
In 2010, an Iberian ibex (Capra pyrenaica hispanica) stock reservoir was established for conservation purposes in north-eastern Spain. Eighteen ibexes were captured in the wild and housed in a 17 hectare enclosure. Once in captivity, a caseous lymphadenitis (CLA) outbreak occurred and ibex handlings...
| Autores: | , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2014 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:185132 |
| Acceso en línea: | https://ddd.uab.cat/record/185132 https://dx.doi.org/urn:doi:10.1186/s13028-014-0083-x |
| Access Level: | acceso abierto |
| Palabra clave: | Capra pyrenaica Corynebacterium pseudotuberculosis Caseous lymphadenitis Antibodies Autovaccine Acute phase proteins |
| id |
ES_a710542b6902eb236741f2a5be7ae5fb |
|---|---|
| oai_identifier_str |
oai:ddd.uab.cat:185132 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Management of a caseous lymphadenitis outbreak in a new Iberian ibex (Capra pyrenaica) stock reservoirColom Cadena, Andreu|||0000-0003-0983-2412Velarde, Roser|||0000-0003-3332-6405Salinas, JesúsBorge, CarmenGarcía Bocanegra, Ignacio|||0000-0003-3388-2604Serrano Ferron, Emmanuel|||0000-0002-9799-9804Gassó, Diana|||0000-0003-4553-8528Bach i Raich, EsterCasas Díaz, Encarna|||0000-0002-5901-6555López Olvera, Jorge R.|||0000-0002-2999-3451Lavín González, Santiago|||0000-0001-5655-588XLeón-Vizcaíno, LuísMentaberre García, Gregorio|||0000-0001-9542-7514Capra pyrenaicaCorynebacterium pseudotuberculosisCaseous lymphadenitisAntibodiesAutovaccineAcute phase proteinsIn 2010, an Iberian ibex (Capra pyrenaica hispanica) stock reservoir was established for conservation purposes in north-eastern Spain. Eighteen ibexes were captured in the wild and housed in a 17 hectare enclosure. Once in captivity, a caseous lymphadenitis (CLA) outbreak occurred and ibex handlings were carried out at six-month intervals between 2010 and 2013 to perform health examinations and sampling. Treatment with a bacterin-based autovaccine and penicillin G benzatine was added during the third and subsequent handlings, when infection by Corynebacterium pseudotuberculosis was confirmed. Changes in lesion score, serum anti- C. pseudotuberculosis antibodies and haematological parameters were analyzed to assess captivity effects, disease emergence and treatment efficacy. Serum acute phase proteins (APP) Haptoglobin (Hp), Amyloid A (SAA) and Acid Soluble Glycoprotein (ASG) concentrations were also determined to evaluate their usefulness as indicators of clinical status. Once in captivity, 12 out of 14 ibexes (85.7%) seroconverted, preceding the emergence of clinical signs; moreover, TP, WBC, eosinophil and platelet cell counts increased while monocyte and basophil cell counts decreased. After treatment, casualties and fistulas disappeared and both packed cell volume (PCV) and haemoglobin concentration significantly increased. Hp, SAA and ASG values were under the limit of detection or showed no significant differences. A role for captivity in contagion rate is suggested by the increase in antibody levels against C. pseudotuberculosis and the emergence of clinical signs. Although boosted by captivity, this is the first report of an outbreak of caseous lymphadenitis displaying high morbidity and mortality in wild ungulates. Treatment consisting of both vaccination and antibiotic therapy seemed to prevent mortality and alleviate disease severity, but was not reflected in the humoural response. Haematology and APP were not useful indicators in our study, perhaps due to the sampling frequency. Presumably endemic and irrelevant in the wild, this common disease of domestic small ruminants is complicating conservation efforts for the Iberian ibex in north-eastern Spain. 22014-01-0120142014-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/185132https://dx.doi.org/urn:doi:10.1186/s13028-014-0083-xreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1851322026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Management of a caseous lymphadenitis outbreak in a new Iberian ibex (Capra pyrenaica) stock reservoir |
| title |
Management of a caseous lymphadenitis outbreak in a new Iberian ibex (Capra pyrenaica) stock reservoir |
| spellingShingle |
Management of a caseous lymphadenitis outbreak in a new Iberian ibex (Capra pyrenaica) stock reservoir Colom Cadena, Andreu|||0000-0003-0983-2412 Capra pyrenaica Corynebacterium pseudotuberculosis Caseous lymphadenitis Antibodies Autovaccine Acute phase proteins |
| title_short |
Management of a caseous lymphadenitis outbreak in a new Iberian ibex (Capra pyrenaica) stock reservoir |
| title_full |
Management of a caseous lymphadenitis outbreak in a new Iberian ibex (Capra pyrenaica) stock reservoir |
| title_fullStr |
Management of a caseous lymphadenitis outbreak in a new Iberian ibex (Capra pyrenaica) stock reservoir |
| title_full_unstemmed |
Management of a caseous lymphadenitis outbreak in a new Iberian ibex (Capra pyrenaica) stock reservoir |
| title_sort |
Management of a caseous lymphadenitis outbreak in a new Iberian ibex (Capra pyrenaica) stock reservoir |
| dc.creator.none.fl_str_mv |
Colom Cadena, Andreu|||0000-0003-0983-2412 Velarde, Roser|||0000-0003-3332-6405 Salinas, Jesús Borge, Carmen García Bocanegra, Ignacio|||0000-0003-3388-2604 Serrano Ferron, Emmanuel|||0000-0002-9799-9804 Gassó, Diana|||0000-0003-4553-8528 Bach i Raich, Ester Casas Díaz, Encarna|||0000-0002-5901-6555 López Olvera, Jorge R.|||0000-0002-2999-3451 Lavín González, Santiago|||0000-0001-5655-588X León-Vizcaíno, Luís Mentaberre García, Gregorio|||0000-0001-9542-7514 |
| author |
Colom Cadena, Andreu|||0000-0003-0983-2412 |
| author_facet |
Colom Cadena, Andreu|||0000-0003-0983-2412 Velarde, Roser|||0000-0003-3332-6405 Salinas, Jesús Borge, Carmen García Bocanegra, Ignacio|||0000-0003-3388-2604 Serrano Ferron, Emmanuel|||0000-0002-9799-9804 Gassó, Diana|||0000-0003-4553-8528 Bach i Raich, Ester Casas Díaz, Encarna|||0000-0002-5901-6555 López Olvera, Jorge R.|||0000-0002-2999-3451 Lavín González, Santiago|||0000-0001-5655-588X León-Vizcaíno, Luís Mentaberre García, Gregorio|||0000-0001-9542-7514 |
| author_role |
author |
| author2 |
Velarde, Roser|||0000-0003-3332-6405 Salinas, Jesús Borge, Carmen García Bocanegra, Ignacio|||0000-0003-3388-2604 Serrano Ferron, Emmanuel|||0000-0002-9799-9804 Gassó, Diana|||0000-0003-4553-8528 Bach i Raich, Ester Casas Díaz, Encarna|||0000-0002-5901-6555 López Olvera, Jorge R.|||0000-0002-2999-3451 Lavín González, Santiago|||0000-0001-5655-588X León-Vizcaíno, Luís Mentaberre García, Gregorio|||0000-0001-9542-7514 |
| author2_role |
author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Capra pyrenaica Corynebacterium pseudotuberculosis Caseous lymphadenitis Antibodies Autovaccine Acute phase proteins |
| topic |
Capra pyrenaica Corynebacterium pseudotuberculosis Caseous lymphadenitis Antibodies Autovaccine Acute phase proteins |
| description |
In 2010, an Iberian ibex (Capra pyrenaica hispanica) stock reservoir was established for conservation purposes in north-eastern Spain. Eighteen ibexes were captured in the wild and housed in a 17 hectare enclosure. Once in captivity, a caseous lymphadenitis (CLA) outbreak occurred and ibex handlings were carried out at six-month intervals between 2010 and 2013 to perform health examinations and sampling. Treatment with a bacterin-based autovaccine and penicillin G benzatine was added during the third and subsequent handlings, when infection by Corynebacterium pseudotuberculosis was confirmed. Changes in lesion score, serum anti- C. pseudotuberculosis antibodies and haematological parameters were analyzed to assess captivity effects, disease emergence and treatment efficacy. Serum acute phase proteins (APP) Haptoglobin (Hp), Amyloid A (SAA) and Acid Soluble Glycoprotein (ASG) concentrations were also determined to evaluate their usefulness as indicators of clinical status. Once in captivity, 12 out of 14 ibexes (85.7%) seroconverted, preceding the emergence of clinical signs; moreover, TP, WBC, eosinophil and platelet cell counts increased while monocyte and basophil cell counts decreased. After treatment, casualties and fistulas disappeared and both packed cell volume (PCV) and haemoglobin concentration significantly increased. Hp, SAA and ASG values were under the limit of detection or showed no significant differences. A role for captivity in contagion rate is suggested by the increase in antibody levels against C. pseudotuberculosis and the emergence of clinical signs. Although boosted by captivity, this is the first report of an outbreak of caseous lymphadenitis displaying high morbidity and mortality in wild ungulates. Treatment consisting of both vaccination and antibiotic therapy seemed to prevent mortality and alleviate disease severity, but was not reflected in the humoural response. Haematology and APP were not useful indicators in our study, perhaps due to the sampling frequency. Presumably endemic and irrelevant in the wild, this common disease of domestic small ruminants is complicating conservation efforts for the Iberian ibex in north-eastern Spain. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2 2014-01-01 2014 2014-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/185132 https://dx.doi.org/urn:doi:10.1186/s13028-014-0083-x |
| url |
https://ddd.uab.cat/record/185132 https://dx.doi.org/urn:doi:10.1186/s13028-014-0083-x |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
| instname_str |
Universitat Autònoma de Barcelona |
| reponame_str |
Dipòsit Digital de Documents de la UAB |
| collection |
Dipòsit Digital de Documents de la UAB |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869415748007362560 |
| score |
15,198674 |