The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond

The small GTPase Ran regulates the interaction of transport receptors with a number of cellular cargo proteins. The high affinity binding of the GTP-bound form of Ran to import receptors promotes cargo release, whereas its binding to export receptors stabilizes their interaction with the cargo. This...

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Detalhes bibliográficos
Autores: Cavazza, Tommaso, 1985-, Vernos, Isabelle, 1959-
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2016
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/58397
Acesso em linha:http://hdl.handle.net/10230/58397
http://dx.doi.org/10.3389/fcell.2015.00082
Access Level:Acceso aberto
Palavra-chave:Spindle
RanGTP
Microtubule
Cell division
Importin
SAF
Nucleo-cytoplasmic transport
Exportin
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spelling The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyondCavazza, Tommaso, 1985-Vernos, Isabelle, 1959-SpindleRanGTPMicrotubuleCell divisionImportinSAFNucleo-cytoplasmic transportExportinThe small GTPase Ran regulates the interaction of transport receptors with a number of cellular cargo proteins. The high affinity binding of the GTP-bound form of Ran to import receptors promotes cargo release, whereas its binding to export receptors stabilizes their interaction with the cargo. This basic mechanism linked to the asymmetric distribution of the two nucleotide-bound forms of Ran between the nucleus and the cytoplasm generates a switch like mechanism controlling nucleo-cytoplasmic transport. Since 1999, we have known that after nuclear envelope breakdown (NEBD) Ran and the above transport receptors also provide a local control over the activity of factors driving spindle assembly and regulating other aspects of cell division. The identification and functional characterization of RanGTP mitotic targets is providing novel insights into mechanisms essential for cell division. Here we review our current knowledge on the RanGTP system and its regulation and we focus on the recent advances made through the characterization of its mitotic targets. We then briefly review the novel functions of the pathway that were recently described. Altogether, the RanGTP system has moonlighting functions exerting a spatial control over protein interactions that drive specific functions depending on the cellular context.TC was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) through the FPI fellowship BES-2010-031355. Work in the Vernos lab was supported by the Spanish ministry grants BFU2009-10202 and BFU2012-37163, co-financed by the European Regional Development Fund (ERDF/FEDER). We also acknowledge support of the Spanish Ministry of Economy and Competitiveness, “Centro de Excelencia Severo Ochoa 2013-2017,” SEV-2012-0208.Frontiers202320232016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/58397http://dx.doi.org/10.3389/fcell.2015.00082reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFrontiers in Cell and Developmental Biology. 2016 Jan 11;3:82info:eu-repo/grantAgreement/ES/3PN/BES-2010-031355info:eu-repo/grantAgreement/ES/3PN/BFU2009-10202info:eu-repo/grantAgreement/ES/3PN/BFU2012-37163© 2016 Cavazza and Vernos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/583972026-05-29T05:05:01Z
dc.title.none.fl_str_mv The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond
title The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond
spellingShingle The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond
Cavazza, Tommaso, 1985-
Spindle
RanGTP
Microtubule
Cell division
Importin
SAF
Nucleo-cytoplasmic transport
Exportin
title_short The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond
title_full The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond
title_fullStr The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond
title_full_unstemmed The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond
title_sort The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond
dc.creator.none.fl_str_mv Cavazza, Tommaso, 1985-
Vernos, Isabelle, 1959-
author Cavazza, Tommaso, 1985-
author_facet Cavazza, Tommaso, 1985-
Vernos, Isabelle, 1959-
author_role author
author2 Vernos, Isabelle, 1959-
author2_role author
dc.subject.none.fl_str_mv Spindle
RanGTP
Microtubule
Cell division
Importin
SAF
Nucleo-cytoplasmic transport
Exportin
topic Spindle
RanGTP
Microtubule
Cell division
Importin
SAF
Nucleo-cytoplasmic transport
Exportin
description The small GTPase Ran regulates the interaction of transport receptors with a number of cellular cargo proteins. The high affinity binding of the GTP-bound form of Ran to import receptors promotes cargo release, whereas its binding to export receptors stabilizes their interaction with the cargo. This basic mechanism linked to the asymmetric distribution of the two nucleotide-bound forms of Ran between the nucleus and the cytoplasm generates a switch like mechanism controlling nucleo-cytoplasmic transport. Since 1999, we have known that after nuclear envelope breakdown (NEBD) Ran and the above transport receptors also provide a local control over the activity of factors driving spindle assembly and regulating other aspects of cell division. The identification and functional characterization of RanGTP mitotic targets is providing novel insights into mechanisms essential for cell division. Here we review our current knowledge on the RanGTP system and its regulation and we focus on the recent advances made through the characterization of its mitotic targets. We then briefly review the novel functions of the pathway that were recently described. Altogether, the RanGTP system has moonlighting functions exerting a spatial control over protein interactions that drive specific functions depending on the cellular context.
publishDate 2016
dc.date.none.fl_str_mv 2016
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/58397
http://dx.doi.org/10.3389/fcell.2015.00082
url http://hdl.handle.net/10230/58397
http://dx.doi.org/10.3389/fcell.2015.00082
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Cell and Developmental Biology. 2016 Jan 11;3:82
info:eu-repo/grantAgreement/ES/3PN/BES-2010-031355
info:eu-repo/grantAgreement/ES/3PN/BFU2009-10202
info:eu-repo/grantAgreement/ES/3PN/BFU2012-37163
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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