Recent advances in Pichia pastoris as host for heterologous expression system for lipases

The production of heterologous lipases is one of the most promising strategies to increase the productivity of the bioprocesses and to reduce costs, with the final objective that more industrial lipase applications could be implemented. In this chapter, an overview of the new success in synthetic bi...

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Detalhes bibliográficos
Autor: Valero, Francisco|||0000-0003-0429-9620
Formato: capítulo de livro
Fecha de publicación:2018
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:200900
Acesso em linha:https://ddd.uab.cat/record/200900
https://dx.doi.org/urn:doi:10.1007/978-1-4939-8672-9_11
Access Level:acceso abierto
Palavra-chave:Microbial lipases
Heterologous expression
Bioprocess engineering
Synthetic biology
Candida rugosa
Rhizopus oryzae
Candida antarctica
Pichia pastoris
Descrição
Resumo:The production of heterologous lipases is one of the most promising strategies to increase the productivity of the bioprocesses and to reduce costs, with the final objective that more industrial lipase applications could be implemented. In this chapter, an overview of the new success in synthetic biology, with traditional molecular genetic techniques and bioprocess engineering in the last 5 years in the cell factory Pichia pastoris, the most promising host system for heterologous lipase production, is presented. The goals get on heterologous Candida antarctica, Rhizopus oryzae, and Candida rugosa lipases, three of the most common lipases used in biocatalysis, are showed. Finally, new cell factories producing heterologous lipases are presented.