Visible-light mediated synthesis of bicalutamide by regioselective hydroxysulfonylation of acrylamides

Synthesis of anticancer drug bicalutamide promoted by visible light in one step from the corresponding N-arylacrylamide is described. This approach involves a one-pot hydroxysulfonylation reaction through a photocatalytic redox process. The use of Na2Eosin Y as photocatalyst and blue light allows th...

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Detalles Bibliográficos
Autores: Merino Marcos, Estibaliz|||0000-0002-2960-5404, Zurro de la Fuente, Mercedes|||0000-0003-1222-7926, Torres Oya, Sergio|||0000-0002-1003-519X
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/57892
Acceso en línea:http://hdl.handle.net/10017/57892
https://dx.doi.org/10.1002/ejoc.202300535
Access Level:acceso abierto
Palabra clave:Química
Chemistry
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spelling Visible-light mediated synthesis of bicalutamide by regioselective hydroxysulfonylation of acrylamidesMerino Marcos, Estibaliz|||0000-0002-2960-5404Zurro de la Fuente, Mercedes|||0000-0003-1222-7926Torres Oya, Sergio|||0000-0002-1003-519XQuímicaChemistrySynthesis of anticancer drug bicalutamide promoted by visible light in one step from the corresponding N-arylacrylamide is described. This approach involves a one-pot hydroxysulfonylation reaction through a photocatalytic redox process. The use of Na2Eosin Y as photocatalyst and blue light allows the access to a broad range of alfa-hydroxysulfonylamides bearing a quaternary center in moderate to good yields with complete regioselectivity via radical process.European UnionComunidad de MadridUniversidad de Alcalá20232023-08-04journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/57892https://dx.doi.org/10.1002/ejoc.202300535reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/578922026-06-18T11:13:07Z
dc.title.none.fl_str_mv Visible-light mediated synthesis of bicalutamide by regioselective hydroxysulfonylation of acrylamides
title Visible-light mediated synthesis of bicalutamide by regioselective hydroxysulfonylation of acrylamides
spellingShingle Visible-light mediated synthesis of bicalutamide by regioselective hydroxysulfonylation of acrylamides
Merino Marcos, Estibaliz|||0000-0002-2960-5404
Química
Chemistry
title_short Visible-light mediated synthesis of bicalutamide by regioselective hydroxysulfonylation of acrylamides
title_full Visible-light mediated synthesis of bicalutamide by regioselective hydroxysulfonylation of acrylamides
title_fullStr Visible-light mediated synthesis of bicalutamide by regioselective hydroxysulfonylation of acrylamides
title_full_unstemmed Visible-light mediated synthesis of bicalutamide by regioselective hydroxysulfonylation of acrylamides
title_sort Visible-light mediated synthesis of bicalutamide by regioselective hydroxysulfonylation of acrylamides
dc.creator.none.fl_str_mv Merino Marcos, Estibaliz|||0000-0002-2960-5404
Zurro de la Fuente, Mercedes|||0000-0003-1222-7926
Torres Oya, Sergio|||0000-0002-1003-519X
author Merino Marcos, Estibaliz|||0000-0002-2960-5404
author_facet Merino Marcos, Estibaliz|||0000-0002-2960-5404
Zurro de la Fuente, Mercedes|||0000-0003-1222-7926
Torres Oya, Sergio|||0000-0002-1003-519X
author_role author
author2 Zurro de la Fuente, Mercedes|||0000-0003-1222-7926
Torres Oya, Sergio|||0000-0002-1003-519X
author2_role author
author
dc.subject.none.fl_str_mv Química
Chemistry
topic Química
Chemistry
description Synthesis of anticancer drug bicalutamide promoted by visible light in one step from the corresponding N-arylacrylamide is described. This approach involves a one-pot hydroxysulfonylation reaction through a photocatalytic redox process. The use of Na2Eosin Y as photocatalyst and blue light allows the access to a broad range of alfa-hydroxysulfonylamides bearing a quaternary center in moderate to good yields with complete regioselectivity via radical process.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-08-04
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/57892
https://dx.doi.org/10.1002/ejoc.202300535
url http://hdl.handle.net/10017/57892
https://dx.doi.org/10.1002/ejoc.202300535
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
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repository.mail.fl_str_mv
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