COVID-19–associated venous thromboembolism: risk of recurrence and major bleeding

© 2023 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Detalles Bibliográficos
Autores: Demelo-Rodríguez, Pablo, Alonso-Beato, Rubén, Jara Palomares, Luis, Galeano-Valle, Francisco, Bura-Riviere, Alessandra, Visonà, Adriana, Francisco, Iria, Vidal, Gemma, López-Ruiz, Antonio, Monreal, Manuel, RIETE Investigators
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/349979
Acceso en línea:http://hdl.handle.net/10261/349979
Access Level:acceso abierto
Palabra clave:Anticoagulants
COVID-19
Hemorrhage
Pulmonary embolism
Venous thromboembolism
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spelling COVID-19–associated venous thromboembolism: risk of recurrence and major bleedingDemelo-Rodríguez, PabloAlonso-Beato, RubénJara Palomares, LuisGaleano-Valle, FranciscoBura-Riviere, AlessandraVisonà, AdrianaFrancisco, IriaVidal, GemmaLópez-Ruiz, AntonioMonreal, ManuelRIETE InvestigatorsAnticoagulantsCOVID-19HemorrhagePulmonary embolismVenous thromboembolism© 2023 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).[Background] Complications under anticoagulant treatment in patients with COVID-19-associated venous thromboembolism (VTE) have not been consistently reported.[Objectives] This study aimed to compare the 90-day rates of VTE recurrences and major bleeding in patients with COVID-19-associated VTE versus those with VTE without COVID-19.[Methods] We used the RIETE registry to compare the 3-month outcomes in patients with COVID-19-associated VTE versus those with VTE without COVID-19.[Results] The study included 1,747 patients with COVID-19-associated VTE and 8,711 with VTE without COVID-19. Patients with COVID-19-associated VTE were more likely to be hospitalized at baseline and to present with pulmonary embolism. During the first 90 days, 123 patients (1.17%) developed VTE recurrences, and 266 (2.54%) experienced major bleeding. Patients with COVID-19-associated VTE had a similar rate of VTE recurrences (0.9% vs 1.2%) but a higher rate of major bleeding (4.6% vs 2.1%; P < .001) than those without COVID-19. Multivariable analysis adjusted for competing risks showed that patients with COVID-19-associated VTE had an increased risk of major bleeding (subhazard ratio, 1.395; 95% confidence interval, 1.037-1.877). The 30-day mortality after major bleeding was 26.3% in patients with COVID-19-associated VTE and 17.7% in those without COVID-19.[Conclusion] Patients with COVID-19-associated VTE had a 5-fold higher rate of major bleeding than VTE recurrences during the first 90 days of anticoagulation. In VTE patients without COVID-19, both rates were similar. These findings highlight the importance of carefully monitoring and optimizing anticoagulation in these patients.The study was supported by Sanofi Spain and ROVI with an unrestricted educational grant.Peer reviewedElsevierInternational Society on Thrombosis and HaemostasisSanofi EspañaLaboratorios Farmacéuticos ROVIConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/349979reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésThe underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1016/j.rpth.2023.102206https://doi.org/10.1016/j.rpth.2023.102206Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3499792026-05-22T06:33:51Z
dc.title.none.fl_str_mv COVID-19–associated venous thromboembolism: risk of recurrence and major bleeding
title COVID-19–associated venous thromboembolism: risk of recurrence and major bleeding
spellingShingle COVID-19–associated venous thromboembolism: risk of recurrence and major bleeding
Demelo-Rodríguez, Pablo
Anticoagulants
COVID-19
Hemorrhage
Pulmonary embolism
Venous thromboembolism
title_short COVID-19–associated venous thromboembolism: risk of recurrence and major bleeding
title_full COVID-19–associated venous thromboembolism: risk of recurrence and major bleeding
title_fullStr COVID-19–associated venous thromboembolism: risk of recurrence and major bleeding
title_full_unstemmed COVID-19–associated venous thromboembolism: risk of recurrence and major bleeding
title_sort COVID-19–associated venous thromboembolism: risk of recurrence and major bleeding
dc.creator.none.fl_str_mv Demelo-Rodríguez, Pablo
Alonso-Beato, Rubén
Jara Palomares, Luis
Galeano-Valle, Francisco
Bura-Riviere, Alessandra
Visonà, Adriana
Francisco, Iria
Vidal, Gemma
López-Ruiz, Antonio
Monreal, Manuel
RIETE Investigators
author Demelo-Rodríguez, Pablo
author_facet Demelo-Rodríguez, Pablo
Alonso-Beato, Rubén
Jara Palomares, Luis
Galeano-Valle, Francisco
Bura-Riviere, Alessandra
Visonà, Adriana
Francisco, Iria
Vidal, Gemma
López-Ruiz, Antonio
Monreal, Manuel
RIETE Investigators
author_role author
author2 Alonso-Beato, Rubén
Jara Palomares, Luis
Galeano-Valle, Francisco
Bura-Riviere, Alessandra
Visonà, Adriana
Francisco, Iria
Vidal, Gemma
López-Ruiz, Antonio
Monreal, Manuel
RIETE Investigators
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Sanofi España
Laboratorios Farmacéuticos ROVI
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Anticoagulants
COVID-19
Hemorrhage
Pulmonary embolism
Venous thromboembolism
topic Anticoagulants
COVID-19
Hemorrhage
Pulmonary embolism
Venous thromboembolism
description © 2023 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/349979
url http://hdl.handle.net/10261/349979
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1016/j.rpth.2023.102206
https://doi.org/10.1016/j.rpth.2023.102206
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
International Society on Thrombosis and Haemostasis
publisher.none.fl_str_mv Elsevier
International Society on Thrombosis and Haemostasis
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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