From the animal house to the field: Are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)?

Arriero Higueras, Elena; Wanelik, Klara M.; Birtles, Richard J.; Bradley, Janette E.; Jackson, Joseph A.; Paterson, Steve; Begon, Mike

From the animal house to the field: Are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)?

Inbred mouse strains, living in simple laboratory environments far removed from nature, have been shown to vary consistently in their immune response. However, wildlife populations are typically outbreeding and face a multiplicity of challenges, parasitological and otherwise. In this study we seek e...

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Detalhes bibliográficos
Autores:	Arriero Higueras, Elena, Wanelik, Klara M., Birtles, Richard J., Bradley, Janette E., Jackson, Joseph A., Paterson, Steve, Begon, Mike
Formato:	artículo
Fecha de publicación:	2017
País:	España
Recursos:	Universidad Complutense de Madrid (UCM)
Repositorio:	Docta Complutense
Idioma:	inglés
OAI Identifier:	oai:docta.ucm.es:20.500.14352/18324
Acesso em linha:	https://hdl.handle.net/20.500.14352/18324
Access Level:	acceso abierto
Palavra-chave:	599.32 591.1 Microtus agrestis Immunological profile Fisiología animal (Biología) Mamíferos 2401.13 Fisiología Animal 2401.18 Mamíferos

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spelling	From the animal house to the field: Are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)?Arriero Higueras, ElenaWanelik, Klara M.Birtles, Richard J.Bradley, Janette E.Jackson, Joseph A.Paterson, SteveBegon, Mike599.32591.1Microtus agrestisImmunological profileFisiología animal (Biología)Mamíferos2401.13 Fisiología Animal2401.18 MamíferosInbred mouse strains, living in simple laboratory environments far removed from nature, have been shown to vary consistently in their immune response. However, wildlife populations are typically outbreeding and face a multiplicity of challenges, parasitological and otherwise. In this study we seek evidence of consistent difference in immunological profile amongst individuals in the wild. We apply a novel method in this context, using longitudinal (repeated capture) data from natural populations of field voles, Microtus agrestis, on a range of life history and infection metrics, and on gene expression levels. We focus on three immune genes, IFN-γ, Gata3, and IL-10, representing respectively the Th1, Th2 and regulatory elements of the immune response. Our results show that there was clear evidence of consistent differences between individuals in their typical level of expression of at least one immune gene, and at most all three immune genes, after other measured sources of variation had been taken into account. Furthermore, individuals that responded to changing circumstances by increasing expression levels of Gata3 had a correlated increase in expression levels of IFN-γ. Our work stresses the importance of acknowledging immunological variation amongst individuals in studies of parasitological and infectious disease risk in wildlife populations.Public Library of Sciences (PLOS)Universidad Complutense de Madrid20172017-01-0120172017-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/18324reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/183242026-06-02T12:44:21Z
dc.title.none.fl_str_mv	From the animal house to the field: Are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)?
title	From the animal house to the field: Are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)?
spellingShingle	From the animal house to the field: Are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)? Arriero Higueras, Elena 599.32 591.1 Microtus agrestis Immunological profile Fisiología animal (Biología) Mamíferos 2401.13 Fisiología Animal 2401.18 Mamíferos
title_short	From the animal house to the field: Are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)?
title_full	From the animal house to the field: Are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)?
title_fullStr	From the animal house to the field: Are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)?
title_full_unstemmed	From the animal house to the field: Are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)?
title_sort	From the animal house to the field: Are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)?
dc.creator.none.fl_str_mv	Arriero Higueras, Elena Wanelik, Klara M. Birtles, Richard J. Bradley, Janette E. Jackson, Joseph A. Paterson, Steve Begon, Mike
author	Arriero Higueras, Elena
author_facet	Arriero Higueras, Elena Wanelik, Klara M. Birtles, Richard J. Bradley, Janette E. Jackson, Joseph A. Paterson, Steve Begon, Mike
author_role	author
author2	Wanelik, Klara M. Birtles, Richard J. Bradley, Janette E. Jackson, Joseph A. Paterson, Steve Begon, Mike
author2_role	author author author author author author
dc.contributor.none.fl_str_mv	Universidad Complutense de Madrid
dc.subject.none.fl_str_mv	599.32 591.1 Microtus agrestis Immunological profile Fisiología animal (Biología) Mamíferos 2401.13 Fisiología Animal 2401.18 Mamíferos
topic	599.32 591.1 Microtus agrestis Immunological profile Fisiología animal (Biología) Mamíferos 2401.13 Fisiología Animal 2401.18 Mamíferos
description	Inbred mouse strains, living in simple laboratory environments far removed from nature, have been shown to vary consistently in their immune response. However, wildlife populations are typically outbreeding and face a multiplicity of challenges, parasitological and otherwise. In this study we seek evidence of consistent difference in immunological profile amongst individuals in the wild. We apply a novel method in this context, using longitudinal (repeated capture) data from natural populations of field voles, Microtus agrestis, on a range of life history and infection metrics, and on gene expression levels. We focus on three immune genes, IFN-γ, Gata3, and IL-10, representing respectively the Th1, Th2 and regulatory elements of the immune response. Our results show that there was clear evidence of consistent differences between individuals in their typical level of expression of at least one immune gene, and at most all three immune genes, after other measured sources of variation had been taken into account. Furthermore, individuals that responded to changing circumstances by increasing expression levels of Gata3 had a correlated increase in expression levels of IFN-γ. Our work stresses the importance of acknowledging immunological variation amongst individuals in studies of parasitological and infectious disease risk in wildlife populations.
publishDate	2017
dc.date.none.fl_str_mv	2017 2017-01-01 2017 2017-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.14352/18324
url	https://hdl.handle.net/20.500.14352/18324
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Public Library of Sciences (PLOS)
publisher.none.fl_str_mv	Public Library of Sciences (PLOS)
dc.source.none.fl_str_mv	reponame:Docta Complutense instname:Universidad Complutense de Madrid (UCM)
instname_str	Universidad Complutense de Madrid (UCM)
reponame_str	Docta Complutense
collection	Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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From the animal house to the field: Are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)?

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