Epileptogenic zone localization with (18)FDG PET using a new dynamic parametric analysis
Introduction: [18F]fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) is part of the regular preoperative work-up in medically refractory epilepsy. As a complement to visual evaluation of PET, statistical parametric maps can help in the detection of the epileptogenic zone (EZ). However,...
| Autores: | , , , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Recursos: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/163163 |
| Acesso em linha: | https://hdl.handle.net/2445/163163 |
| Access Level: | acceso abierto |
| Palavra-chave: | Tomografia computada per emissió de fotó simple Epilèpsia Neurocirurgia Single-photon emission computed tomography Epilepsy Neurosurgery |
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Epileptogenic zone localization with (18)FDG PET using a new dynamic parametric analysisMayoral Peñalva, MariaNiñerola Baizán, AidaMarti Fuster, BertaDonaire Pedraza, Antonio JesúsPerissinotti, AndrésRumià, JordiBargalló Alabart, NúriaSala Llonch, RoserPavía Segura, JavierRos Puig, DomènecCarreño, MarPons Pons, FranciscaSetoain Perego, XavierTomografia computada per emissió de fotó simpleEpilèpsiaNeurocirurgiaSingle-photon emission computed tomographyEpilepsyNeurosurgeryIntroduction: [18F]fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) is part of the regular preoperative work-up in medically refractory epilepsy. As a complement to visual evaluation of PET, statistical parametric maps can help in the detection of the epileptogenic zone (EZ). However, software packages currently available are time-consuming and little intuitive for physicians. We develop a user-friendly software (referred as PET-analysis) for EZ localization in PET studies that allows dynamic real-time statistical parametric analysis. To evaluate its performance, the outcome of PET-analysis was compared with the results obtained by visual assessment and Statistical Parametric Mapping (SPM). Methods: Thirty patients with medically refractory epilepsy who underwent presurgical 18F-FDG PET with good post-operative outcomes were included. The 18F-FDG PET studies were evaluated by visual assessment, with SPM8 and PET-analysis. In SPM, parametric T-maps were thresholded at corrected p < 0.05 and cluster size k = 50 and at uncorrected p < 0.001 and k = 100 (the most used parameters in the literature). Since PET-analysis rapidly processes different threshold combinations, T-maps were thresholded with multiple p-value and different clusters sizes. The presurgical EZ identified by visual assessment, SPM and PET-analysis was compared to the confirmed EZ according to post-surgical follow-up. Results: PET-analysis obtained 66.7% (20/30) of correctly localizing studies, comparable to the 70.0% (21/30) achieved by visual assessment and significantly higher (p < 0.05) than that obtained with the SPM threshold p < 0.001/k = 100, of 36.7% (11/30). Only one study was positive, albeit non-localizing, with the SPM threshold corrected p < 0.05/k = 50. Concordance was substantial for PET-analysis (κ = 0.643) and visual interpretation (κ = 0.622), being fair for SPM (κ = 0.242). Conclusion: Compared to SPM with the fixed standard parameters, PET-analysis may be superior in EZ localization with its easy and rapid processing of different threshold combinations. The results of this initial proof-of-concept study validate the clinical use of PET-analysis as a robust objective complementary tool to visual assessment for EZ localization.Frontiers Media2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/163163Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fneur.2019.00380Frontiers In Neurology, 2019, vol. 10, num. 380https://doi.org/10.3389/fneur.2019.00380cc-by (c) Mayoral Peñalva, Maria et al., 2019http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1631632026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Epileptogenic zone localization with (18)FDG PET using a new dynamic parametric analysis |
| title |
Epileptogenic zone localization with (18)FDG PET using a new dynamic parametric analysis |
| spellingShingle |
Epileptogenic zone localization with (18)FDG PET using a new dynamic parametric analysis Mayoral Peñalva, Maria Tomografia computada per emissió de fotó simple Epilèpsia Neurocirurgia Single-photon emission computed tomography Epilepsy Neurosurgery |
| title_short |
Epileptogenic zone localization with (18)FDG PET using a new dynamic parametric analysis |
| title_full |
Epileptogenic zone localization with (18)FDG PET using a new dynamic parametric analysis |
| title_fullStr |
Epileptogenic zone localization with (18)FDG PET using a new dynamic parametric analysis |
| title_full_unstemmed |
Epileptogenic zone localization with (18)FDG PET using a new dynamic parametric analysis |
| title_sort |
Epileptogenic zone localization with (18)FDG PET using a new dynamic parametric analysis |
| dc.creator.none.fl_str_mv |
Mayoral Peñalva, Maria Niñerola Baizán, Aida Marti Fuster, Berta Donaire Pedraza, Antonio Jesús Perissinotti, Andrés Rumià, Jordi Bargalló Alabart, Núria Sala Llonch, Roser Pavía Segura, Javier Ros Puig, Domènec Carreño, Mar Pons Pons, Francisca Setoain Perego, Xavier |
| author |
Mayoral Peñalva, Maria |
| author_facet |
Mayoral Peñalva, Maria Niñerola Baizán, Aida Marti Fuster, Berta Donaire Pedraza, Antonio Jesús Perissinotti, Andrés Rumià, Jordi Bargalló Alabart, Núria Sala Llonch, Roser Pavía Segura, Javier Ros Puig, Domènec Carreño, Mar Pons Pons, Francisca Setoain Perego, Xavier |
| author_role |
author |
| author2 |
Niñerola Baizán, Aida Marti Fuster, Berta Donaire Pedraza, Antonio Jesús Perissinotti, Andrés Rumià, Jordi Bargalló Alabart, Núria Sala Llonch, Roser Pavía Segura, Javier Ros Puig, Domènec Carreño, Mar Pons Pons, Francisca Setoain Perego, Xavier |
| author2_role |
author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Tomografia computada per emissió de fotó simple Epilèpsia Neurocirurgia Single-photon emission computed tomography Epilepsy Neurosurgery |
| topic |
Tomografia computada per emissió de fotó simple Epilèpsia Neurocirurgia Single-photon emission computed tomography Epilepsy Neurosurgery |
| description |
Introduction: [18F]fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) is part of the regular preoperative work-up in medically refractory epilepsy. As a complement to visual evaluation of PET, statistical parametric maps can help in the detection of the epileptogenic zone (EZ). However, software packages currently available are time-consuming and little intuitive for physicians. We develop a user-friendly software (referred as PET-analysis) for EZ localization in PET studies that allows dynamic real-time statistical parametric analysis. To evaluate its performance, the outcome of PET-analysis was compared with the results obtained by visual assessment and Statistical Parametric Mapping (SPM). Methods: Thirty patients with medically refractory epilepsy who underwent presurgical 18F-FDG PET with good post-operative outcomes were included. The 18F-FDG PET studies were evaluated by visual assessment, with SPM8 and PET-analysis. In SPM, parametric T-maps were thresholded at corrected p < 0.05 and cluster size k = 50 and at uncorrected p < 0.001 and k = 100 (the most used parameters in the literature). Since PET-analysis rapidly processes different threshold combinations, T-maps were thresholded with multiple p-value and different clusters sizes. The presurgical EZ identified by visual assessment, SPM and PET-analysis was compared to the confirmed EZ according to post-surgical follow-up. Results: PET-analysis obtained 66.7% (20/30) of correctly localizing studies, comparable to the 70.0% (21/30) achieved by visual assessment and significantly higher (p < 0.05) than that obtained with the SPM threshold p < 0.001/k = 100, of 36.7% (11/30). Only one study was positive, albeit non-localizing, with the SPM threshold corrected p < 0.05/k = 50. Concordance was substantial for PET-analysis (κ = 0.643) and visual interpretation (κ = 0.622), being fair for SPM (κ = 0.242). Conclusion: Compared to SPM with the fixed standard parameters, PET-analysis may be superior in EZ localization with its easy and rapid processing of different threshold combinations. The results of this initial proof-of-concept study validate the clinical use of PET-analysis as a robust objective complementary tool to visual assessment for EZ localization. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/163163 |
| url |
https://hdl.handle.net/2445/163163 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.3389/fneur.2019.00380 Frontiers In Neurology, 2019, vol. 10, num. 380 https://doi.org/10.3389/fneur.2019.00380 |
| dc.rights.none.fl_str_mv |
cc-by (c) Mayoral Peñalva, Maria et al., 2019 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess |
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cc-by (c) Mayoral Peñalva, Maria et al., 2019 http://creativecommons.org/licenses/by/3.0/es |
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openAccess |
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application/pdf |
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Frontiers Media |
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Frontiers Media |
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Articles publicats en revistes (Biomedicina) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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