Anencephaly and severe myelodysplasia in a stillborn brown bear (Ursus arctos arctos)

6 páginas, 2 figuras.

Detalles Bibliográficos
Autores: Balseiro, Ana, Polledo, Laura, Tuñón, J., García Marín, Juan Francisco
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/281253
Acceso en línea:http://hdl.handle.net/10261/281253
Access Level:acceso abierto
Palabra clave:Brown bear
Ursus arctos arctos
Congenital nervous system
Malformation
Anencephaly
Spina bifida
Myelodysplasia
Syringomyelia
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spelling Anencephaly and severe myelodysplasia in a stillborn brown bear (Ursus arctos arctos)Balseiro, AnaPolledo, LauraTuñón, J.García Marín, Juan FranciscoBrown bearUrsus arctos arctosCongenital nervous systemMalformationAnencephalySpina bifidaMyelodysplasiaSyringomyelia6 páginas, 2 figuras.Malformations in the development of the neural tube have been described to be associated with different aetiologies, such as genetic factors, toxic plants, chemical products, viral agents, or hyperthermia. A twenty-four-year-old female Eurasian brown bear (Ursus arctos arctos), permanently in captivity and kept under food and management control, gave birth to a stillborn cub at the end of gestation. Several malformations resulting from the anomalous development of the neural tube, not previously reported in bears, were observed, such as anencephaly, hypoplasia, micromyelia, severe myelodysplasia, syringomyelia, and spina bifida. Multiple canal defects (e.g., absence) were also observed in the spinal cord. In some regions, the intradural nerve roots surrounded the spinal cord in a diffuse and continuous way. The aetiology remains unidentified, although the advanced age of the mother and/or folic acid deficit might have been the possible causes of this disorder. Supplements of folate given to the mother before and during early pregnancy may have reduced the incidence of neural tube defects. That supplementation should be considered when the reproduction of bears is to occur in captivity, in order to prevent the loss of future generations of this endangered species.This work was partially funded by the Principality of Asturias (PCTI 2021–2023, GRUPIN: IDI-2021-000102) and the European Regional Development FundPeer reviewedMultidisciplinary Digital Publishing InstituteEuropean CommissionPrincipado de AsturiasBalseiro Morales, Ana María [0000-0002-5121-7264]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/281253reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3390/ani12182345Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2812532026-05-22T06:33:51Z
dc.title.none.fl_str_mv Anencephaly and severe myelodysplasia in a stillborn brown bear (Ursus arctos arctos)
title Anencephaly and severe myelodysplasia in a stillborn brown bear (Ursus arctos arctos)
spellingShingle Anencephaly and severe myelodysplasia in a stillborn brown bear (Ursus arctos arctos)
Balseiro, Ana
Brown bear
Ursus arctos arctos
Congenital nervous system
Malformation
Anencephaly
Spina bifida
Myelodysplasia
Syringomyelia
title_short Anencephaly and severe myelodysplasia in a stillborn brown bear (Ursus arctos arctos)
title_full Anencephaly and severe myelodysplasia in a stillborn brown bear (Ursus arctos arctos)
title_fullStr Anencephaly and severe myelodysplasia in a stillborn brown bear (Ursus arctos arctos)
title_full_unstemmed Anencephaly and severe myelodysplasia in a stillborn brown bear (Ursus arctos arctos)
title_sort Anencephaly and severe myelodysplasia in a stillborn brown bear (Ursus arctos arctos)
dc.creator.none.fl_str_mv Balseiro, Ana
Polledo, Laura
Tuñón, J.
García Marín, Juan Francisco
author Balseiro, Ana
author_facet Balseiro, Ana
Polledo, Laura
Tuñón, J.
García Marín, Juan Francisco
author_role author
author2 Polledo, Laura
Tuñón, J.
García Marín, Juan Francisco
author2_role author
author
author
dc.contributor.none.fl_str_mv European Commission
Principado de Asturias
Balseiro Morales, Ana María [0000-0002-5121-7264]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Brown bear
Ursus arctos arctos
Congenital nervous system
Malformation
Anencephaly
Spina bifida
Myelodysplasia
Syringomyelia
topic Brown bear
Ursus arctos arctos
Congenital nervous system
Malformation
Anencephaly
Spina bifida
Myelodysplasia
Syringomyelia
description 6 páginas, 2 figuras.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/281253
url http://hdl.handle.net/10261/281253
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3390/ani12182345
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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