Snail blocks the cell cycle and confers resistance to cell death

The Snail zinc-finger transcription factors trigger epithelial-mesenchymal transitions (EMTs), endowing epithelial cells with migratory and invasive properties during both embryonic development and tumor progression. During EMT, Snail provokes the loss of epithelial markers, as well as changes in ce...

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Authors: Vega, Sonia, Morales, Aixa V., Ocaña, Oscar H., Valdés, Francisco, Fabregat Romero, Isabel, Nieto, M. Angela
Format: article
Status:Published version
Publication Date:2004
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/47366
Online Access:https://hdl.handle.net/2445/47366
Access Level:Open access
Keyword:Mort cel·lular
Embriologia
Trastorns del desenvolupament
Animals
Éssers humans
Apoptosi
Cell death
Embryology
Developmental disabilities
Human beings
Apoptosis
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oai_identifier_str oai:recercat.cat:2445/47366
network_acronym_str ES
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repository_id_str
spelling Snail blocks the cell cycle and confers resistance to cell deathVega, SoniaMorales, Aixa V.Ocaña, Oscar H.Valdés, FranciscoFabregat Romero, IsabelNieto, M. AngelaMort cel·lularEmbriologiaTrastorns del desenvolupamentAnimalsÉssers humansApoptosiCell deathEmbryologyDevelopmental disabilitiesAnimalsHuman beingsApoptosisThe Snail zinc-finger transcription factors trigger epithelial-mesenchymal transitions (EMTs), endowing epithelial cells with migratory and invasive properties during both embryonic development and tumor progression. During EMT, Snail provokes the loss of epithelial markers, as well as changes in cell shape and the expression of mesenchymal markers. Here, we show that in addition to inducing dramatic phenotypic alterations, Snail attenuates the cell cycle and confers resistance to cell death induced by the withdrawal of survival factors and by pro-apoptotic signals. Hence, Snail favors changes in cell shape versus cell division, indicating that with respect to oncogenesis, although a deregulation/increase in proliferation is crucial for tumor formation and growth, this may not be so for tumor malignization. Finally, the resistance to cell death conferred by Snail provides a selective advantage to embryonic cells to migrate and colonize distant territories, and to malignant cells to separate from the primary tumor, invade, and form metastasis.Cold Spring Harbor Laboratory Press2013201320042013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/47366Articles publicats en revistes (Ciències Fisiològiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1101/gad.294104Genes & Development, 2004, vol. 18, p. 1131-1143http://dx.doi.org/10.1101/gad.294104(c) Vega, Sonia et al., 2004info:eu-repo/semantics/openAccessoai:recercat.cat:2445/473662026-05-29T05:05:01Z
dc.title.none.fl_str_mv Snail blocks the cell cycle and confers resistance to cell death
title Snail blocks the cell cycle and confers resistance to cell death
spellingShingle Snail blocks the cell cycle and confers resistance to cell death
Vega, Sonia
Mort cel·lular
Embriologia
Trastorns del desenvolupament
Animals
Éssers humans
Apoptosi
Cell death
Embryology
Developmental disabilities
Animals
Human beings
Apoptosis
title_short Snail blocks the cell cycle and confers resistance to cell death
title_full Snail blocks the cell cycle and confers resistance to cell death
title_fullStr Snail blocks the cell cycle and confers resistance to cell death
title_full_unstemmed Snail blocks the cell cycle and confers resistance to cell death
title_sort Snail blocks the cell cycle and confers resistance to cell death
dc.creator.none.fl_str_mv Vega, Sonia
Morales, Aixa V.
Ocaña, Oscar H.
Valdés, Francisco
Fabregat Romero, Isabel
Nieto, M. Angela
author Vega, Sonia
author_facet Vega, Sonia
Morales, Aixa V.
Ocaña, Oscar H.
Valdés, Francisco
Fabregat Romero, Isabel
Nieto, M. Angela
author_role author
author2 Morales, Aixa V.
Ocaña, Oscar H.
Valdés, Francisco
Fabregat Romero, Isabel
Nieto, M. Angela
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Mort cel·lular
Embriologia
Trastorns del desenvolupament
Animals
Éssers humans
Apoptosi
Cell death
Embryology
Developmental disabilities
Animals
Human beings
Apoptosis
topic Mort cel·lular
Embriologia
Trastorns del desenvolupament
Animals
Éssers humans
Apoptosi
Cell death
Embryology
Developmental disabilities
Animals
Human beings
Apoptosis
description The Snail zinc-finger transcription factors trigger epithelial-mesenchymal transitions (EMTs), endowing epithelial cells with migratory and invasive properties during both embryonic development and tumor progression. During EMT, Snail provokes the loss of epithelial markers, as well as changes in cell shape and the expression of mesenchymal markers. Here, we show that in addition to inducing dramatic phenotypic alterations, Snail attenuates the cell cycle and confers resistance to cell death induced by the withdrawal of survival factors and by pro-apoptotic signals. Hence, Snail favors changes in cell shape versus cell division, indicating that with respect to oncogenesis, although a deregulation/increase in proliferation is crucial for tumor formation and growth, this may not be so for tumor malignization. Finally, the resistance to cell death conferred by Snail provides a selective advantage to embryonic cells to migrate and colonize distant territories, and to malignant cells to separate from the primary tumor, invade, and form metastasis.
publishDate 2004
dc.date.none.fl_str_mv 2004
2013
2013
2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/47366
url https://hdl.handle.net/2445/47366
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1101/gad.294104
Genes & Development, 2004, vol. 18, p. 1131-1143
http://dx.doi.org/10.1101/gad.294104
dc.rights.none.fl_str_mv (c) Vega, Sonia et al., 2004
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Vega, Sonia et al., 2004
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,228081

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