Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections
Abstract Background: Few previous retrospective studies suggest that Plasmodium ovale wallikeri seems to have a longer latency period and produces deeper thrombocytopaenia than Plasmodium ovale curtisi. Prospective studies were warranted to better assess interspecies differences. Methods: Patients w...
| Autores: | , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/60489 |
| Acceso en línea: | http://hdl.handle.net/10017/60489 https://dx.doi.org/10.1186/s12936-018-2544-6 |
| Access Level: | acceso abierto |
| Palabra clave: | Plasmodium ovale curtisi Plasmodium ovale wallikeri Comparative study Thrombocytopenia INR Antimalarials Diabetes mellitus Biología y Biomedicina/Biología Biology |
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Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infectionsCuadros González, Juan|||0000-0003-4098-4377Rojo Marcos, GerardoRubio Muñoz, José MiguelAngheben, AndreaJaureguiberry, StephaneGarcía Bujalance, SilviaTomasoni, Lina RacheleRodríguez Valero, NataliaRuiz Giardín, José ManuelSalas Coronas, JoaquínGarcía Rodríguez, MagdalenaMolina Romero, IsraelLópez-Vélez Pérez, RogelioGobbi, FedericoCalderón Moreno, MaríaMartín Echevarría, EstebanElía López, MatildeLlovo Taboada, JoséTropNet Plasmodium ovale investigator groupPlasmodium ovale curtisiPlasmodium ovale wallikeriComparative studyThrombocytopeniaINRAntimalarialsDiabetes mellitusBiología y Biomedicina/BiologíaBiologyAbstract Background: Few previous retrospective studies suggest that Plasmodium ovale wallikeri seems to have a longer latency period and produces deeper thrombocytopaenia than Plasmodium ovale curtisi. Prospective studies were warranted to better assess interspecies differences. Methods: Patients with imported P. ovale spp. infection diagnosed by thick or thin film, rapid diagnostic test (RDT) or polymerase chain reaction (PCR) were recruited between March 2014 and May 2017. All were confirmed by DNA isolation and classified as P. o. curtisi or P. o. wallikeri using partial sequencing of the ssrRNA gene. Epidemiological, analytical and clinical differences were analysed by statistical methods. Results: A total of 79 samples (35 P. o. curtisi and 44 P. o. wallikeri) were correctly genotyped. Males predominate in wallikeri group (72.7%), whereas were 48.6% in curtisi group. Conversely, 74.3% of curtisi group were from patients of African ethnicity, whilst 52.3% of Caucasians were infected by P. o. wallikeri. After performing a multivariate analysis, more thrombocytopaenic patients (p = 0.022), a lower number of platelets (p = 0.015), a higher INR value (p = 0.041), and shorter latency in Caucasians (p = 0.034) were significantly seen in P. o. wallikeri. RDT sensitivity was 26.1% in P. o. curtisi and 42.4% in P. o. wallikeri. Nearly 20% of both species were diagnosed only by PCR. Total bilirubin over 3 mg/ dL was found in three wallikeri cases. Two patients with curtisi infection had haemoglobin under 7 g/dL, one of them also with icterus. A wallikeri patient suffered from haemophagocytosis. Chemoprophylaxis failed in 14.8% and 35% of curtisi and wallikeri patients, respectively. All treated patients with various anti-malarials which included artesunate recovered. Diabetes mellitus was described in 5 patients (6.32%), 4 patients of wallikeri group and 1 curtisi. Conclusions: Imported P. o. wallikeri infection may be more frequent in males and Caucasians. Malaria caused by P. o. wallikeri produces more thrombocytopaenia, a higher INR and shorter latency in Caucasians and suggests a more pathogenic species. Severe cases can be seen in both species. Chemoprophylaxis seems less effective in P. ovale spp. infection than in P. falciparum, but any anti-malarial drug is effective as initial treatment. Diabetes mellitus could be a risk factor for P. ovale spp. infection.Fundación para la Investigación Biomédica del Hospital Universitario Príncipe de Asturias20182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/60489https://dx.doi.org/10.1186/s12936-018-2544-6reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengNot available Not available Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/604892026-06-18T11:13:07Z |
| dc.title.none.fl_str_mv |
Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections |
| title |
Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections |
| spellingShingle |
Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections Cuadros González, Juan|||0000-0003-4098-4377 Plasmodium ovale curtisi Plasmodium ovale wallikeri Comparative study Thrombocytopenia INR Antimalarials Diabetes mellitus Biología y Biomedicina/Biología Biology |
| title_short |
Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections |
| title_full |
Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections |
| title_fullStr |
Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections |
| title_full_unstemmed |
Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections |
| title_sort |
Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections |
| dc.creator.none.fl_str_mv |
Cuadros González, Juan|||0000-0003-4098-4377 Rojo Marcos, Gerardo Rubio Muñoz, José Miguel Angheben, Andrea Jaureguiberry, Stephane García Bujalance, Silvia Tomasoni, Lina Rachele Rodríguez Valero, Natalia Ruiz Giardín, José Manuel Salas Coronas, Joaquín García Rodríguez, Magdalena Molina Romero, Israel López-Vélez Pérez, Rogelio Gobbi, Federico Calderón Moreno, María Martín Echevarría, Esteban Elía López, Matilde Llovo Taboada, José TropNet Plasmodium ovale investigator group |
| author |
Cuadros González, Juan|||0000-0003-4098-4377 |
| author_facet |
Cuadros González, Juan|||0000-0003-4098-4377 Rojo Marcos, Gerardo Rubio Muñoz, José Miguel Angheben, Andrea Jaureguiberry, Stephane García Bujalance, Silvia Tomasoni, Lina Rachele Rodríguez Valero, Natalia Ruiz Giardín, José Manuel Salas Coronas, Joaquín García Rodríguez, Magdalena Molina Romero, Israel López-Vélez Pérez, Rogelio Gobbi, Federico Calderón Moreno, María Martín Echevarría, Esteban Elía López, Matilde Llovo Taboada, José TropNet Plasmodium ovale investigator group |
| author_role |
author |
| author2 |
Rojo Marcos, Gerardo Rubio Muñoz, José Miguel Angheben, Andrea Jaureguiberry, Stephane García Bujalance, Silvia Tomasoni, Lina Rachele Rodríguez Valero, Natalia Ruiz Giardín, José Manuel Salas Coronas, Joaquín García Rodríguez, Magdalena Molina Romero, Israel López-Vélez Pérez, Rogelio Gobbi, Federico Calderón Moreno, María Martín Echevarría, Esteban Elía López, Matilde Llovo Taboada, José TropNet Plasmodium ovale investigator group |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Plasmodium ovale curtisi Plasmodium ovale wallikeri Comparative study Thrombocytopenia INR Antimalarials Diabetes mellitus Biología y Biomedicina/Biología Biology |
| topic |
Plasmodium ovale curtisi Plasmodium ovale wallikeri Comparative study Thrombocytopenia INR Antimalarials Diabetes mellitus Biología y Biomedicina/Biología Biology |
| description |
Abstract Background: Few previous retrospective studies suggest that Plasmodium ovale wallikeri seems to have a longer latency period and produces deeper thrombocytopaenia than Plasmodium ovale curtisi. Prospective studies were warranted to better assess interspecies differences. Methods: Patients with imported P. ovale spp. infection diagnosed by thick or thin film, rapid diagnostic test (RDT) or polymerase chain reaction (PCR) were recruited between March 2014 and May 2017. All were confirmed by DNA isolation and classified as P. o. curtisi or P. o. wallikeri using partial sequencing of the ssrRNA gene. Epidemiological, analytical and clinical differences were analysed by statistical methods. Results: A total of 79 samples (35 P. o. curtisi and 44 P. o. wallikeri) were correctly genotyped. Males predominate in wallikeri group (72.7%), whereas were 48.6% in curtisi group. Conversely, 74.3% of curtisi group were from patients of African ethnicity, whilst 52.3% of Caucasians were infected by P. o. wallikeri. After performing a multivariate analysis, more thrombocytopaenic patients (p = 0.022), a lower number of platelets (p = 0.015), a higher INR value (p = 0.041), and shorter latency in Caucasians (p = 0.034) were significantly seen in P. o. wallikeri. RDT sensitivity was 26.1% in P. o. curtisi and 42.4% in P. o. wallikeri. Nearly 20% of both species were diagnosed only by PCR. Total bilirubin over 3 mg/ dL was found in three wallikeri cases. Two patients with curtisi infection had haemoglobin under 7 g/dL, one of them also with icterus. A wallikeri patient suffered from haemophagocytosis. Chemoprophylaxis failed in 14.8% and 35% of curtisi and wallikeri patients, respectively. All treated patients with various anti-malarials which included artesunate recovered. Diabetes mellitus was described in 5 patients (6.32%), 4 patients of wallikeri group and 1 curtisi. Conclusions: Imported P. o. wallikeri infection may be more frequent in males and Caucasians. Malaria caused by P. o. wallikeri produces more thrombocytopaenia, a higher INR and shorter latency in Caucasians and suggests a more pathogenic species. Severe cases can be seen in both species. Chemoprophylaxis seems less effective in P. ovale spp. infection than in P. falciparum, but any anti-malarial drug is effective as initial treatment. Diabetes mellitus could be a risk factor for P. ovale spp. infection. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 2018-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 NA http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10017/60489 https://dx.doi.org/10.1186/s12936-018-2544-6 |
| url |
http://hdl.handle.net/10017/60489 https://dx.doi.org/10.1186/s12936-018-2544-6 |
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Inglés eng |
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Inglés |
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eng |
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Not available Not available Not available |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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reponame:e_Buah Biblioteca Digital Universidad de Alcalá instname:Universidad de Alcalá (UAH) |
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