Exploring the tubular self-assembly landscape of dinucleobase amphiphiles in water
The design and production of the next generations of synthetic aqueous self-Assembled systems able to mimic some biological features will require increasingly sophisticated monomer constituents that make use of additional interactions to hydrophibic effects to attain enhanced structural and function...
| Autores: | , , , , , |
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| Formato: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Recursos: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/698319 |
| Acesso em linha: | http://hdl.handle.net/10486/698319 https://dx.doi.org/10.1039/d0qo01110j |
| Access Level: | acceso abierto |
| Palavra-chave: | Carboxylation Hydrophilicity Nanotubes Self assembly Stereochemistry Amphiphilic monomers Biological features Monomers Self-assembled systems Química |
| Resumo: | The design and production of the next generations of synthetic aqueous self-Assembled systems able to mimic some biological features will require increasingly sophisticated monomer constituents that make use of additional interactions to hydrophibic effects to attain enhanced structural and functional complexity. Here, we broadly investigate the aqueous self-Assembly of dinucleobase amphiphilic monomers into helical nanotubes under a wide range of different conditions of temperature, concentration, solvent composition and pH. Such monomers comprise an amphiphilic π-conjugated central block, endowed with a lipophilic chiral tail and a hydrophilic group that can be made anionic (carboxylate), neutral (glycol) or cationic (ammonium), disubstituted with complementary guanine and cytosine nucleobases at each termini. These molecules self-Assemble into amphiphilic nanotubes in water but, when subjected to diverse (drastic) changes in the experimental conditions, undergo either disassembly into monomers, chiral reorganization, or a morphological restructuration into globular objects due to dehydration of the peripheral hydrophilic groups |
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