Changes in lutein status markers (serum and faecal concentrations, macular pigment) in response to a lutein-rich fruit or vegetable (three pieces/day) dietary intervention in normolipemic subjects

This article belongs to the Special Issue Carotenoid Biomarkers of Dietary Exposure and Nutritional Status.

Detalhes bibliográficos
Autores: Olmedilla-Alonso, Begoña, Rodríguez-Rodríguez, Elena, Beltrán de Miguel, Beatriz, Sánchez-Prieto, Milagros, Estévez Santiago, Rocío
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/267045
Acesso em linha:http://hdl.handle.net/10261/267045
Access Level:Acceso aberto
Palavra-chave:Lutein
HDL-cholesterol
Xanthophylls
Contrast threshold
Carotenoids
Macular pigment
Human serum
Intervention study
Dietary intake
Faeces
id ES_9861c4fb3a48ca4082a4b3f65bba8d0c
oai_identifier_str oai:digital.csic.es:10261/267045
network_acronym_str ES
network_name_str España
repository_id_str
spelling Changes in lutein status markers (serum and faecal concentrations, macular pigment) in response to a lutein-rich fruit or vegetable (three pieces/day) dietary intervention in normolipemic subjectsOlmedilla-Alonso, BegoñaRodríguez-Rodríguez, ElenaBeltrán de Miguel, BeatrizSánchez-Prieto, MilagrosEstévez Santiago, RocíoLuteinHDL-cholesterolXanthophyllsContrast thresholdCarotenoidsMacular pigmentHuman serumIntervention studyDietary intakeFaecesThis article belongs to the Special Issue Carotenoid Biomarkers of Dietary Exposure and Nutritional Status.Lutein is mainly supplied by dietary fruit and vegetables, and they are commonly jointly assessed in observational and interventional studies. Lutein bioavailability and health benefits depend on the food matrix. This study aimed to assess the effect of dietary intervention with lutein-rich fruit or vegetables on lutein status markers, including serum and faecal concentrations (by high pressure liquid chromatography), dietary intake (24 h recalls ×3), and macular pigment optical density (MPOD) and contrast threshold (CT) as visual outcomes. Twenty-nine healthy normolipemic subjects, aged 45–65 y, consumed 1.8 mg lutein/day supplied from fruits (14 subjects, 500 g/day of oranges, kiwi and avocados) or vegetables (15 subjects, 180 g/day of green beans, pumpkin, and sweet corn) for four weeks. Serum lutein concentration increased by 37%. The effect of the food group intervention was statistically significant for serum lutein+zeaxanthin concentration (p = 0.049). Serum α- and β-carotene were influenced by food type (p = 0.008 and p = 0.005, respectively), but not by time. Serum lutein/HDL-cholesterol level increased by 29% (total sample, p = 0.008). Lutein+zeaxanthin/HDL-cholesterol increased, and the intervention time and food group eaten had an effect (p = 0.024 and p = 0.010, respectively) which was higher in the vegetable group. The MPOD did not show variations, nor did it correlate with CT. According to correlation matrixes, serum lutein was mainly related to lutein+zeaxanthin expressed in relation to lipids, and MPOD with the vegetable group. In faecal samples, only lutein levels increased (p = 0.012). This study shows that a relatively low amount of lutein, supplied by fruit or vegetables, can have different responses in correlated status markers, and that a longer intervention period is needed to increase the MPOD. Therefore, further study with larger sample sizes is needed on the different responses in the lutein status markers and on food types and consumption patterns in the diet, and when lutein in a “pharmacological dose” is not taken to reduce a specific risk.This study was funded by a grant from the Instituto de Salud Carlos III (Ministerio de Ciencia e Innovación, Spain) (grant PI16/01991) and co-funded by the ERDF/European Social Fund. We would also like to acknowledge the support of the Spanish National Research Council (CSIC) (grant P. intramural 201970E033) for the dietary assessment.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Instituto de Salud Carlos IIIConsejo Superior de Investigaciones Científicas (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/267045reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/nu13103614Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2670452026-05-22T06:33:51Z
dc.title.none.fl_str_mv Changes in lutein status markers (serum and faecal concentrations, macular pigment) in response to a lutein-rich fruit or vegetable (three pieces/day) dietary intervention in normolipemic subjects
title Changes in lutein status markers (serum and faecal concentrations, macular pigment) in response to a lutein-rich fruit or vegetable (three pieces/day) dietary intervention in normolipemic subjects
spellingShingle Changes in lutein status markers (serum and faecal concentrations, macular pigment) in response to a lutein-rich fruit or vegetable (three pieces/day) dietary intervention in normolipemic subjects
Olmedilla-Alonso, Begoña
Lutein
HDL-cholesterol
Xanthophylls
Contrast threshold
Carotenoids
Macular pigment
Human serum
Intervention study
Dietary intake
Faeces
title_short Changes in lutein status markers (serum and faecal concentrations, macular pigment) in response to a lutein-rich fruit or vegetable (three pieces/day) dietary intervention in normolipemic subjects
title_full Changes in lutein status markers (serum and faecal concentrations, macular pigment) in response to a lutein-rich fruit or vegetable (three pieces/day) dietary intervention in normolipemic subjects
title_fullStr Changes in lutein status markers (serum and faecal concentrations, macular pigment) in response to a lutein-rich fruit or vegetable (three pieces/day) dietary intervention in normolipemic subjects
title_full_unstemmed Changes in lutein status markers (serum and faecal concentrations, macular pigment) in response to a lutein-rich fruit or vegetable (three pieces/day) dietary intervention in normolipemic subjects
title_sort Changes in lutein status markers (serum and faecal concentrations, macular pigment) in response to a lutein-rich fruit or vegetable (three pieces/day) dietary intervention in normolipemic subjects
dc.creator.none.fl_str_mv Olmedilla-Alonso, Begoña
Rodríguez-Rodríguez, Elena
Beltrán de Miguel, Beatriz
Sánchez-Prieto, Milagros
Estévez Santiago, Rocío
author Olmedilla-Alonso, Begoña
author_facet Olmedilla-Alonso, Begoña
Rodríguez-Rodríguez, Elena
Beltrán de Miguel, Beatriz
Sánchez-Prieto, Milagros
Estévez Santiago, Rocío
author_role author
author2 Rodríguez-Rodríguez, Elena
Beltrán de Miguel, Beatriz
Sánchez-Prieto, Milagros
Estévez Santiago, Rocío
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Instituto de Salud Carlos III
Consejo Superior de Investigaciones Científicas (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Lutein
HDL-cholesterol
Xanthophylls
Contrast threshold
Carotenoids
Macular pigment
Human serum
Intervention study
Dietary intake
Faeces
topic Lutein
HDL-cholesterol
Xanthophylls
Contrast threshold
Carotenoids
Macular pigment
Human serum
Intervention study
Dietary intake
Faeces
description This article belongs to the Special Issue Carotenoid Biomarkers of Dietary Exposure and Nutritional Status.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/267045
url http://hdl.handle.net/10261/267045
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/nu13103614
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414188751781888
score 15,812455

Registros relacionados