Longitudinal growth assessment for prediction of adverse perinatal outcome in fetuses suspected to be small-for-gestational age

Objective Fetal growth restriction (FGR) is associated with an increased risk of adverse perinatal outcome. However, distinguishing this condition from small-for-gestational age (SGA) remains elusive. A set of criteria has been proposed recently for such a purpose, including the degree of smallness,...

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Autores: Caradeux J, Eixarch E, Mazarico E, Basuki TR, Gratacos E, Figueras F
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p12828
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12828
Access Level:acceso abierto
Palabra clave:adverse perinatal outcome
fetal growth
fetal growth restriction
longitudinal growth
ultrasound
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spelling Longitudinal growth assessment for prediction of adverse perinatal outcome in fetuses suspected to be small-for-gestational ageCaradeux JEixarch EMazarico EBasuki TRGratacos EFigueras Fadverse perinatal outcomefetal growthfetal growth restrictionlongitudinal growthultrasoundObjective Fetal growth restriction (FGR) is associated with an increased risk of adverse perinatal outcome. However, distinguishing this condition from small-for-gestational age (SGA) remains elusive. A set of criteria has been proposed recently for such a purpose, including the degree of smallness, Doppler parameters and growth velocity. The aim of this study was to establish whether the use of growth velocity adds value to Doppler assessment in predicting adverse perinatal outcome among SGA-suspected fetuses. Methods This was a prospective cohort study of consecutive singleton pregnancies with late (diagnosis >= 32.0 weeks) SGA (estimated fetal weight (EFW) < 10th centile). Longitudinal growth assessment was performed by calculation of EFW z-velocity between diagnosis and last scan before delivery. Improvement in the association with and predictive performance of EFW z-velocity for adverse perinatal outcome was compared against standard criteria of FGR evaluated before delivery (EFW < 3rd centile, abnormal uterine Doppler or abnormal cerebroplacental ratio). Result A total of 472 patients were evaluated prospectively for suspected SGA. Of these, 231 (48.9%) qualified as late FGR. Univariate analysis showed a significant trend towards higher frequency (14.5% vs 8.2%; P = 0.041) of EFW z-velocity in the lowest decile in pregnancies with adverse perinatal outcome. Nonetheless, the addition of EFW z-velocity improved neither the association with nor the predictive performance of standard criteria of FGR for adverse perinatal outcome. Conclusions Longitudinal assessment of fetal growth by means of EFW z-velocity did not have any independent predictive value for adverse perinatal outcome when used in combination with Doppler in SGA-suspected fetuses. Copyright (c) 2017 ISUOG. Published by John Wiley & Sons Ltd.WILEY2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12828ULTRASOUND IN OBSTETRICS & GYNECOLOGYISSN: 09607692ISSNe: 14690705reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p128282026-05-27T12:37:41Z
dc.title.none.fl_str_mv Longitudinal growth assessment for prediction of adverse perinatal outcome in fetuses suspected to be small-for-gestational age
title Longitudinal growth assessment for prediction of adverse perinatal outcome in fetuses suspected to be small-for-gestational age
spellingShingle Longitudinal growth assessment for prediction of adverse perinatal outcome in fetuses suspected to be small-for-gestational age
Caradeux J
adverse perinatal outcome
fetal growth
fetal growth restriction
longitudinal growth
ultrasound
title_short Longitudinal growth assessment for prediction of adverse perinatal outcome in fetuses suspected to be small-for-gestational age
title_full Longitudinal growth assessment for prediction of adverse perinatal outcome in fetuses suspected to be small-for-gestational age
title_fullStr Longitudinal growth assessment for prediction of adverse perinatal outcome in fetuses suspected to be small-for-gestational age
title_full_unstemmed Longitudinal growth assessment for prediction of adverse perinatal outcome in fetuses suspected to be small-for-gestational age
title_sort Longitudinal growth assessment for prediction of adverse perinatal outcome in fetuses suspected to be small-for-gestational age
dc.creator.none.fl_str_mv Caradeux J
Eixarch E
Mazarico E
Basuki TR
Gratacos E
Figueras F
author Caradeux J
author_facet Caradeux J
Eixarch E
Mazarico E
Basuki TR
Gratacos E
Figueras F
author_role author
author2 Eixarch E
Mazarico E
Basuki TR
Gratacos E
Figueras F
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv adverse perinatal outcome
fetal growth
fetal growth restriction
longitudinal growth
ultrasound
topic adverse perinatal outcome
fetal growth
fetal growth restriction
longitudinal growth
ultrasound
description Objective Fetal growth restriction (FGR) is associated with an increased risk of adverse perinatal outcome. However, distinguishing this condition from small-for-gestational age (SGA) remains elusive. A set of criteria has been proposed recently for such a purpose, including the degree of smallness, Doppler parameters and growth velocity. The aim of this study was to establish whether the use of growth velocity adds value to Doppler assessment in predicting adverse perinatal outcome among SGA-suspected fetuses. Methods This was a prospective cohort study of consecutive singleton pregnancies with late (diagnosis >= 32.0 weeks) SGA (estimated fetal weight (EFW) < 10th centile). Longitudinal growth assessment was performed by calculation of EFW z-velocity between diagnosis and last scan before delivery. Improvement in the association with and predictive performance of EFW z-velocity for adverse perinatal outcome was compared against standard criteria of FGR evaluated before delivery (EFW < 3rd centile, abnormal uterine Doppler or abnormal cerebroplacental ratio). Result A total of 472 patients were evaluated prospectively for suspected SGA. Of these, 231 (48.9%) qualified as late FGR. Univariate analysis showed a significant trend towards higher frequency (14.5% vs 8.2%; P = 0.041) of EFW z-velocity in the lowest decile in pregnancies with adverse perinatal outcome. Nonetheless, the addition of EFW z-velocity improved neither the association with nor the predictive performance of standard criteria of FGR for adverse perinatal outcome. Conclusions Longitudinal assessment of fetal growth by means of EFW z-velocity did not have any independent predictive value for adverse perinatal outcome when used in combination with Doppler in SGA-suspected fetuses. Copyright (c) 2017 ISUOG. Published by John Wiley & Sons Ltd.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12828
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12828
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv ULTRASOUND IN OBSTETRICS & GYNECOLOGY
ISSN: 09607692
ISSNe: 14690705
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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