Supporting Information: Extending thioflavin T fluorescence probe to 2-ethenyl-benzothiazole derivatives: drug-like quadruplex ligands with potent anti-trypanosomatid activity

Synthesis and characterization of benzothiazolium derivatives, parasite and cell culturing, fluorescence microscopy, In silico ADMET properties, FRET-melting assays, CD titrations, UV–vis titrations, pharmacokinetic and toxicity (ADMET) properties, G4-forming and duplex sequences, CD spectra, and HP...

ver descrição completa

Detalhes bibliográficos
Autores: Gonçalves, Raquel C. R., Peñalver, Pablo, Allen, Nina M., Belmonte-Reche, Efres, García-Pérez, Belén, Costa, Susana P. G., Jiang, Y. Jennifer, Pérez-Victoria, José M., Galán, M. Carmen, Raposo, María Manuela M., Morales, Juan Carlos
Tipo de documento: conjunto de datos
Data de publicação:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/415797
Acesso em linha:http://hdl.handle.net/10261/415797
Access Level:Acceso aberto
Palavra-chave:Potential therapeutic effect
Demonstrated superior efficacy
Biophysical studies revealed
Leishmania major amastigotes
Trypanosoma brucei parasites
Fluorescence probe
Extending thioflavin
Bbenzothiazolium derivatives
Descrição
Resumo:Synthesis and characterization of benzothiazolium derivatives, parasite and cell culturing, fluorescence microscopy, In silico ADMET properties, FRET-melting assays, CD titrations, UV–vis titrations, pharmacokinetic and toxicity (ADMET) properties, G4-forming and duplex sequences, CD spectra, and HPLC chromatograms

Registros relacionados