Microencapsulated linseed oil supplementation modifies lipid profile and improves luteal function in dairy sheep

Polyunsaturated fatty acids omega 3 (PUFA- ω3) have been shown to modulate reproductive events such as ovarian follicularand luteal development, steroid and prostaglandin synthesis, and oocyte/embryo quality in different species. These effects couldbe exploited to support pregnancy and avoid early e...

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Autores: Contreras Solís, Ignacio, Porcu, Cristian, Sotgiu, Francesca Daniela, Pasciu, Valeria, Todorova, Neda, Mara, Laura, Chessa, Fabrizio, Addis, Margherita, Fiori, Myriam, Molle, Giovanni, Dattena, Maria, González-Bulnes, Antonio, Abecia, José Alfonso, Berlinguer, Fiammetta
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/56471
Acceso en línea:https://hdl.handle.net/2454/56471
Access Level:acceso abierto
Palabra clave:Ewes
Fertility
Linseed oil
Lipid-metabolism status
Ovarian function
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spelling Microencapsulated linseed oil supplementation modifies lipid profile and improves luteal function in dairy sheepContreras Solís, IgnacioPorcu, CristianSotgiu, Francesca DanielaPasciu, ValeriaTodorova, NedaMara, Laura Chessa, FabrizioAddis, Margherita Fiori, MyriamMolle, GiovanniDattena, MariaGonzález-Bulnes, AntonioAbecia, José AlfonsoBerlinguer, FiammettaEwesFertilityLinseed oilLipid-metabolism statusOvarian functionPolyunsaturated fatty acids omega 3 (PUFA- ω3) have been shown to modulate reproductive events such as ovarian follicularand luteal development, steroid and prostaglandin synthesis, and oocyte/embryo quality in different species. These effects couldbe exploited to support pregnancy and avoid early embryo losses that could occur in dairy sheep breeding. This study aimed toevaluate the effectiveness of dietary supplementation of microencapsulated/by-passed linseed oil (LO) on ovarian function, em-bryo implantation rates, and lipid profiles of Sarda ewes during their early pregnancy. Our results demonstrated that the intakeof microencapsulated LO at a level of 4.0% of fresh matter increased the plasmatic concentrations of PUFASω3 (p < 0.01) andprogesterone (p < 0.05), as well as cholesterol (p < 0.01), triglyceride (p < 0.001), high-density lipoprotein (p < 0.001), and non-esterified fatty acids (p < 0.05). The percentage of ewes in estrus, ovulation rate per mated ewe, number of embryos per ewe, andpregnancy rates were similar between treated and control groups. In conclusion, dietary supplementation of by-pass LO duringthe preimplantation period increased PUFAS- ω3 distribution at systemic and local levels. Also, this supplementation modifiedthe ewe's lipid profile and improved luteal function with a possible positive effect on embryo-maternal crosstalk and embryoimplantation rate during and after the maternal recognition of pregnancy.The study was supported by H2020-MSC Actions Grant number: No. 832326-NUTREPHEALTH.WileyAgronomía, Biotecnología y AlimentaciónAgronomia, Bioteknologia eta Elikadura2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/56471reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/832326© 2025 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work isproperly cited.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/564712026-06-17T12:41:47Z
dc.title.none.fl_str_mv Microencapsulated linseed oil supplementation modifies lipid profile and improves luteal function in dairy sheep
title Microencapsulated linseed oil supplementation modifies lipid profile and improves luteal function in dairy sheep
spellingShingle Microencapsulated linseed oil supplementation modifies lipid profile and improves luteal function in dairy sheep
Contreras Solís, Ignacio
Ewes
Fertility
Linseed oil
Lipid-metabolism status
Ovarian function
title_short Microencapsulated linseed oil supplementation modifies lipid profile and improves luteal function in dairy sheep
title_full Microencapsulated linseed oil supplementation modifies lipid profile and improves luteal function in dairy sheep
title_fullStr Microencapsulated linseed oil supplementation modifies lipid profile and improves luteal function in dairy sheep
title_full_unstemmed Microencapsulated linseed oil supplementation modifies lipid profile and improves luteal function in dairy sheep
title_sort Microencapsulated linseed oil supplementation modifies lipid profile and improves luteal function in dairy sheep
dc.creator.none.fl_str_mv Contreras Solís, Ignacio
Porcu, Cristian
Sotgiu, Francesca Daniela
Pasciu, Valeria
Todorova, Neda
Mara, Laura
Chessa, Fabrizio
Addis, Margherita
Fiori, Myriam
Molle, Giovanni
Dattena, Maria
González-Bulnes, Antonio
Abecia, José Alfonso
Berlinguer, Fiammetta
author Contreras Solís, Ignacio
author_facet Contreras Solís, Ignacio
Porcu, Cristian
Sotgiu, Francesca Daniela
Pasciu, Valeria
Todorova, Neda
Mara, Laura
Chessa, Fabrizio
Addis, Margherita
Fiori, Myriam
Molle, Giovanni
Dattena, Maria
González-Bulnes, Antonio
Abecia, José Alfonso
Berlinguer, Fiammetta
author_role author
author2 Porcu, Cristian
Sotgiu, Francesca Daniela
Pasciu, Valeria
Todorova, Neda
Mara, Laura
Chessa, Fabrizio
Addis, Margherita
Fiori, Myriam
Molle, Giovanni
Dattena, Maria
González-Bulnes, Antonio
Abecia, José Alfonso
Berlinguer, Fiammetta
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Agronomía, Biotecnología y Alimentación
Agronomia, Bioteknologia eta Elikadura
dc.subject.none.fl_str_mv Ewes
Fertility
Linseed oil
Lipid-metabolism status
Ovarian function
topic Ewes
Fertility
Linseed oil
Lipid-metabolism status
Ovarian function
description Polyunsaturated fatty acids omega 3 (PUFA- ω3) have been shown to modulate reproductive events such as ovarian follicularand luteal development, steroid and prostaglandin synthesis, and oocyte/embryo quality in different species. These effects couldbe exploited to support pregnancy and avoid early embryo losses that could occur in dairy sheep breeding. This study aimed toevaluate the effectiveness of dietary supplementation of microencapsulated/by-passed linseed oil (LO) on ovarian function, em-bryo implantation rates, and lipid profiles of Sarda ewes during their early pregnancy. Our results demonstrated that the intakeof microencapsulated LO at a level of 4.0% of fresh matter increased the plasmatic concentrations of PUFASω3 (p < 0.01) andprogesterone (p < 0.05), as well as cholesterol (p < 0.01), triglyceride (p < 0.001), high-density lipoprotein (p < 0.001), and non-esterified fatty acids (p < 0.05). The percentage of ewes in estrus, ovulation rate per mated ewe, number of embryos per ewe, andpregnancy rates were similar between treated and control groups. In conclusion, dietary supplementation of by-pass LO duringthe preimplantation period increased PUFAS- ω3 distribution at systemic and local levels. Also, this supplementation modifiedthe ewe's lipid profile and improved luteal function with a possible positive effect on embryo-maternal crosstalk and embryoimplantation rate during and after the maternal recognition of pregnancy.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/56471
url https://hdl.handle.net/2454/56471
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/832326
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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