The impact of canine leishmaniosis vaccination with CaniLeish® in Leishmania infantum infection seroprevalence studies

Effective vaccines against Leishmania parasites are a goal for the scientific community working with both canine and human leishmaniosis. However, possible side effects of vaccination should also be considered and evaluated, preferably before vaccine licensing and marketing. One of these possible ef...

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Autores: Velez, Maria Rita Perdigão, Domènech Viñolas, Ester, Cairó Vilagran, Jordi, Gállego Culleré, M. (Montserrat)
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/153310
Acceso en línea:https://hdl.handle.net/2445/153310
Access Level:acceso abierto
Palabra clave:Leishmania infantum
Vacunació
Vaccination
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spelling The impact of canine leishmaniosis vaccination with CaniLeish® in Leishmania infantum infection seroprevalence studiesVelez, Maria Rita PerdigãoDomènech Viñolas, EsterCairó Vilagran, JordiGállego Culleré, M. (Montserrat)Leishmania infantumVacunacióLeishmania infantumVaccinationEffective vaccines against Leishmania parasites are a goal for the scientific community working with both canine and human leishmaniosis. However, possible side effects of vaccination should also be considered and evaluated, preferably before vaccine licensing and marketing. One of these possible effects is the cross-reaction of vaccine-induced antibodies with standard serological tests for detection of Leishmania infantum infection. Longitudinal studies were performed on the type of humoral profile induced by Brazilian marketed canine leishmaniosis vaccines, but little is known regarding the European situation. In this study, an annual follow-up of 85 CaniLeish® vaccinated dogs and 83 non-vaccinated control dogs was performed. Blood samples were taken for all animals at pre-determined time points: before vaccination; immediately before each one of the two following vaccine doses (at 21 days intervals); and then one, four, six, nine and 12 months after finishing the vaccination course. All samples were tested by an in-house ELISA, using a whole promastigote antigen, for the presence of anti-L. infantum antibodies. Humoral response detectable by the used serological diagnostic method was significantly higher in the vaccine group when compared with the control group (p < 0.01) until one-month post-vaccination. Results show that CaniLeish® vaccine-induced antibodies cross-react with a commonly used serological test for diagnosis of L. infantum natural infection. Implications of this interference are discussed, with special emphasis on a possible negative impact on canine leishmaniosis surveillance studies.Elsevier B.V.2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/153310Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1016/j.actatropica.2019.105259Acta Tropica, 2020, vol. 202, p. 105259https://doi.org/10.1016/j.actatropica.2019.105259cc-by-nc-nd (c) Elsevier B.V., 2020http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1533102026-05-27T06:46:51Z
dc.title.none.fl_str_mv The impact of canine leishmaniosis vaccination with CaniLeish® in Leishmania infantum infection seroprevalence studies
title The impact of canine leishmaniosis vaccination with CaniLeish® in Leishmania infantum infection seroprevalence studies
spellingShingle The impact of canine leishmaniosis vaccination with CaniLeish® in Leishmania infantum infection seroprevalence studies
Velez, Maria Rita Perdigão
Leishmania infantum
Vacunació
Leishmania infantum
Vaccination
title_short The impact of canine leishmaniosis vaccination with CaniLeish® in Leishmania infantum infection seroprevalence studies
title_full The impact of canine leishmaniosis vaccination with CaniLeish® in Leishmania infantum infection seroprevalence studies
title_fullStr The impact of canine leishmaniosis vaccination with CaniLeish® in Leishmania infantum infection seroprevalence studies
title_full_unstemmed The impact of canine leishmaniosis vaccination with CaniLeish® in Leishmania infantum infection seroprevalence studies
title_sort The impact of canine leishmaniosis vaccination with CaniLeish® in Leishmania infantum infection seroprevalence studies
dc.creator.none.fl_str_mv Velez, Maria Rita Perdigão
Domènech Viñolas, Ester
Cairó Vilagran, Jordi
Gállego Culleré, M. (Montserrat)
author Velez, Maria Rita Perdigão
author_facet Velez, Maria Rita Perdigão
Domènech Viñolas, Ester
Cairó Vilagran, Jordi
Gállego Culleré, M. (Montserrat)
author_role author
author2 Domènech Viñolas, Ester
Cairó Vilagran, Jordi
Gállego Culleré, M. (Montserrat)
author2_role author
author
author
dc.subject.none.fl_str_mv Leishmania infantum
Vacunació
Leishmania infantum
Vaccination
topic Leishmania infantum
Vacunació
Leishmania infantum
Vaccination
description Effective vaccines against Leishmania parasites are a goal for the scientific community working with both canine and human leishmaniosis. However, possible side effects of vaccination should also be considered and evaluated, preferably before vaccine licensing and marketing. One of these possible effects is the cross-reaction of vaccine-induced antibodies with standard serological tests for detection of Leishmania infantum infection. Longitudinal studies were performed on the type of humoral profile induced by Brazilian marketed canine leishmaniosis vaccines, but little is known regarding the European situation. In this study, an annual follow-up of 85 CaniLeish® vaccinated dogs and 83 non-vaccinated control dogs was performed. Blood samples were taken for all animals at pre-determined time points: before vaccination; immediately before each one of the two following vaccine doses (at 21 days intervals); and then one, four, six, nine and 12 months after finishing the vaccination course. All samples were tested by an in-house ELISA, using a whole promastigote antigen, for the presence of anti-L. infantum antibodies. Humoral response detectable by the used serological diagnostic method was significantly higher in the vaccine group when compared with the control group (p < 0.01) until one-month post-vaccination. Results show that CaniLeish® vaccine-induced antibodies cross-react with a commonly used serological test for diagnosis of L. infantum natural infection. Implications of this interference are discussed, with special emphasis on a possible negative impact on canine leishmaniosis surveillance studies.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/153310
url https://hdl.handle.net/2445/153310
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.actatropica.2019.105259
Acta Tropica, 2020, vol. 202, p. 105259
https://doi.org/10.1016/j.actatropica.2019.105259
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier B.V., 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier B.V., 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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