In vitro reversion of amphotericin B resistance in Leishmania donovani by poloxamer 188

A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association against promastigotes. This result was confirmed with amastigotes since the 50% effecti...

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Detalhes bibliográficos
Autores: Espuelas, S. (Socorro)|||/items/b57c05de-0bc4-4fcf-ae1e-c9b2fb92964c, Legrand, P. (P.)|||/items/c7faad1a-cfae-47e6-8485-7a9fcfb7e4dc, Loiseau, P.M. (P.M.)|||/items/60ed0a44-edc3-464c-b0ea-f8dd3dfebe44, Bories, C. (C.)|||/items/1b476a19-90a2-446a-9f1d-2de976eaf2ca, Barratt, G. (G.)|||/items/c500b830-b752-47e8-8d3e-b2511c0552c0, Irache-Garreta, J.M. (Juan Manuel)|||/items/c7cbbe9e-faeb-47e1-b7e8-2d956ca50173
Tipo de documento: artigo
Data de publicação:2000
País:España
Recursos:Universidad de Navarra
Repositório:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglês
OAI Identifier:oai:dadun.unav.edu:10171/19206
Acesso em linha:https://hdl.handle.net/10171/19206
Access Level:Acceso aberto
Palavra-chave:Leishmania donovani
Poloxamer 188
Amphotericin B Resistance
Descrição
Resumo:A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association against promastigotes. This result was confirmed with amastigotes since the 50% effective concentration of the new formulation was 100 times less than that of the control AmB formulation.

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