Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways

Background Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods We studied gut microbiome composition and functionality, and plasma and faecal metabo...

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Autores: Arnoriaga Rodríguez, María, Mayneris Perxachs, Jordi, Contreras-Rodríguez, Oren, Burokas, Aurelijus, Ortega Sanchez, Juan Antonio, Blasco Solà, Gerard, Coll-Martinez, Clàudia, Biarnés, Carles, Castells Nobau, Anna, Puig Alcántara, Josep, Garre Olmo, Josep, Ramos Blanes, Rafel, Pedraza, S., Brugada, Ramon, Vilanova, Joan Carles, Serena, Joaquín, Barretina, Jordi, Gich Fullà, Jordi, Pérez Brocal, Vicente, Moya, Andrés, Fernández-Real, Xavier, Ramió i Torrentà, Lluís, Pamplona, Reinald, Sol, Joaquim, Jové, Mariona, Ricart, Wifredo, Portero Otin, Manuel, Maldonado, Rafael, Fernández-Real Lemos, José Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/19074
Acceso en línea:http://hdl.handle.net/10256/19074
Access Level:acceso abierto
Palabra clave:Intestins -- Microbiologia
Intestines -- Microbiology
Intestins -- Malalties
Intestines -- Diseases
Persones obeses
Overweight persons
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oai_identifier_str oai:recercat.cat:10256/19074
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
title Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
spellingShingle Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
Arnoriaga Rodríguez, María
Intestins -- Microbiologia
Intestines -- Microbiology
Intestins -- Malalties
Intestines -- Diseases
Persones obeses
Overweight persons
title_short Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
title_full Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
title_fullStr Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
title_full_unstemmed Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
title_sort Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
dc.creator.none.fl_str_mv Arnoriaga Rodríguez, María
Mayneris Perxachs, Jordi
Contreras-Rodríguez, Oren
Burokas, Aurelijus
Ortega Sanchez, Juan Antonio
Blasco Solà, Gerard
Coll-Martinez, Clàudia
Biarnés, Carles
Castells Nobau, Anna
Puig Alcántara, Josep
Garre Olmo, Josep
Ramos Blanes, Rafel
Pedraza, S.
Brugada, Ramon
Vilanova, Joan Carles
Serena, Joaquín
Barretina, Jordi
Gich Fullà, Jordi
Pérez Brocal, Vicente
Moya, Andrés
Fernández-Real, Xavier
Ramió i Torrentà, Lluís
Pamplona, Reinald
Sol, Joaquim
Jové, Mariona
Ricart, Wifredo
Portero Otin, Manuel
Maldonado, Rafael
Fernández-Real Lemos, José Manuel
author Arnoriaga Rodríguez, María
author_facet Arnoriaga Rodríguez, María
Mayneris Perxachs, Jordi
Contreras-Rodríguez, Oren
Burokas, Aurelijus
Ortega Sanchez, Juan Antonio
Blasco Solà, Gerard
Coll-Martinez, Clàudia
Biarnés, Carles
Castells Nobau, Anna
Puig Alcántara, Josep
Garre Olmo, Josep
Ramos Blanes, Rafel
Pedraza, S.
Brugada, Ramon
Vilanova, Joan Carles
Serena, Joaquín
Barretina, Jordi
Gich Fullà, Jordi
Pérez Brocal, Vicente
Moya, Andrés
Fernández-Real, Xavier
Ramió i Torrentà, Lluís
Pamplona, Reinald
Sol, Joaquim
Jové, Mariona
Ricart, Wifredo
Portero Otin, Manuel
Maldonado, Rafael
Fernández-Real Lemos, José Manuel
author_role author
author2 Mayneris Perxachs, Jordi
Contreras-Rodríguez, Oren
Burokas, Aurelijus
Ortega Sanchez, Juan Antonio
Blasco Solà, Gerard
Coll-Martinez, Clàudia
Biarnés, Carles
Castells Nobau, Anna
Puig Alcántara, Josep
Garre Olmo, Josep
Ramos Blanes, Rafel
Pedraza, S.
Brugada, Ramon
Vilanova, Joan Carles
Serena, Joaquín
Barretina, Jordi
Gich Fullà, Jordi
Pérez Brocal, Vicente
Moya, Andrés
Fernández-Real, Xavier
Ramió i Torrentà, Lluís
Pamplona, Reinald
Sol, Joaquim
Jové, Mariona
Ricart, Wifredo
Portero Otin, Manuel
Maldonado, Rafael
Fernández-Real Lemos, José Manuel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Intestins -- Microbiologia
Intestines -- Microbiology
Intestins -- Malalties
Intestines -- Diseases
Persones obeses
Overweight persons
topic Intestins -- Microbiologia
Intestines -- Microbiology
Intestins -- Malalties
Intestines -- Diseases
Persones obeses
Overweight persons
description Background Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods We studied gut microbiome composition and functionality, and plasma and faecal metabolomics in association with cognitive tests evaluating inhibitory control (Stroop test) and brain structure in a discovery (n=156), both cross-sectionally and longitudinally, and in an independent replication cohort (n=970). Faecal microbiota transplantation (FMT) in mice evaluated the impact on reversal learning and medial prefrontal cortex (mPFC) transcriptomics. Results An interplay among IC, brain structure (in humans) and mPFC transcriptomics (in mice), plasma/faecal metabolomics and the gut metagenome was found. Obesity-dependent alterations in one-carbon metabolism, tryptophan and histidine pathways were associated with IC in the two independent cohorts. Bacterial functions linked to one-carbon metabolism (thyX,dut, exodeoxyribonuclease V), and the anterior cingulate cortex volume were associated with IC, cross-sectionally and longitudinally. FMT from individuals with obesity led to alterations in mice reversal learning. In an independent FMT experiment, human donor's bacterial functions related to IC deficits were associated with mPFC expression of one-carbon metabolism-related genes of recipient's mice. Conclusion These results highlight the importance of targeting obesity-related impulsive behaviour through the induction of gut microbiota shifts.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/19074
http://hdl.handle.net/10256/19074
url http://hdl.handle.net/10256/19074
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1136/gutjnl-2020-323371
info:eu-repo/semantics/altIdentifier/issn/0017-5749
info:eu-repo/semantics/altIdentifier/eissn/1468-3288
dc.rights.none.fl_str_mv Reconeixement-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reconeixement-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv Gut, 2021, First published January 29, 2021.
Articles publicats (D-CM)
Arnoriaga Rodríguez, María Mayneris Perxchas, Jordi Contreras-Rodríguez, Oren Burokas, Aurelijus Ortega Sanchez, Juan Antonio Blasco Solà, Gerard Coll, Claudia Biarnés, Carles Castells Nobau, Anna Puig, Josep Garre Olmo, Josep Ramos Blanes, Rafel Pedraza Gutiérrez, Salvador Brugada, Ramon Vilanova Busquets, Joan Carles Serena, Joaquín Barretina, Jordi Gich Fullà, Jordi Pérez Brocal, Vicente Moya, Andrés Fernández-Real, Xavier Ramió i Torrentà, Lluís Pamplona, Reinald Sol, Joaquim Jové, Mariona Ricart, Wilfredo Portero Otin, Manuel Maldonado, Rafael Fernández-Real Lemos, José Manuel 2021 Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways Gut undef undef
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathwaysArnoriaga Rodríguez, MaríaMayneris Perxachs, JordiContreras-Rodríguez, OrenBurokas, AurelijusOrtega Sanchez, Juan AntonioBlasco Solà, GerardColl-Martinez, ClàudiaBiarnés, CarlesCastells Nobau, AnnaPuig Alcántara, JosepGarre Olmo, JosepRamos Blanes, RafelPedraza, S.Brugada, RamonVilanova, Joan CarlesSerena, JoaquínBarretina, JordiGich Fullà, JordiPérez Brocal, VicenteMoya, AndrésFernández-Real, XavierRamió i Torrentà, LluísPamplona, ReinaldSol, JoaquimJové, MarionaRicart, WifredoPortero Otin, ManuelMaldonado, RafaelFernández-Real Lemos, José ManuelIntestins -- MicrobiologiaIntestines -- MicrobiologyIntestins -- MalaltiesIntestines -- DiseasesPersones obesesOverweight personsBackground Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods We studied gut microbiome composition and functionality, and plasma and faecal metabolomics in association with cognitive tests evaluating inhibitory control (Stroop test) and brain structure in a discovery (n=156), both cross-sectionally and longitudinally, and in an independent replication cohort (n=970). Faecal microbiota transplantation (FMT) in mice evaluated the impact on reversal learning and medial prefrontal cortex (mPFC) transcriptomics. Results An interplay among IC, brain structure (in humans) and mPFC transcriptomics (in mice), plasma/faecal metabolomics and the gut metagenome was found. Obesity-dependent alterations in one-carbon metabolism, tryptophan and histidine pathways were associated with IC in the two independent cohorts. Bacterial functions linked to one-carbon metabolism (thyX,dut, exodeoxyribonuclease V), and the anterior cingulate cortex volume were associated with IC, cross-sectionally and longitudinally. FMT from individuals with obesity led to alterations in mice reversal learning. In an independent FMT experiment, human donor's bacterial functions related to IC deficits were associated with mPFC expression of one-carbon metabolism-related genes of recipient's mice. Conclusion These results highlight the importance of targeting obesity-related impulsive behaviour through the induction of gut microbiota shifts.This work was partially supported by research grants FIS (PI15/01934 and PI18/01022) from the Instituto de Salud Carlos III from Spain, SAF2015- 65878-R and #AEI-SAF2017-84060-R-FEDER from Ministry of Economy and Competitiveness, Prometeo/2018/A/133 from Generalitat Valenciana, Spain; and also by Fondo Europeo de Desarrollo Regional (FEDER) funds, European Commission (FP7, NeuroPain #2013-602891), the Catalan Government (AGAUR, #SGR2017-669, ICREA Academia Award 2015), the Spanish Instituto de Salud Carlos III (RTA, #RD16/0017/0020), the Spanish Ministry of Science, Innovation and Universities (RTI2018-099200-B-I00), the Catalan Goverment (Agency for Management of University and Research Grants [2017SGR696] and Department of Health [STL002/16/00250]; the European Regional Development Fund (project No. 01.2.2-LMT-K-718-02-0014) under grant agreement with the Research Council of Lithuania (LMTLT); and the Project ThinkGut (EFA345/19) 65% co-financed by the European Regional Development Fund (ERDF) through the Interreg V-A SpainFrance-Andorra programme (POCTEFA 2014-2020). MA-R is funded by a predoctoral Río Hortega contract from the Instituto de Salud Carlos III (ISCIII, CM19/00190), co-funded by the European Social Fund “Investing in your future”. OC-R is funded by the Miguel Servet Program from the Instituto de Salud Carlos III (ISCIII CP20/00165), co-funded by the Europeran Social Fund "Investing in your future". JM-P is funded by the Miguel Servet Program from the Instituto de Salud Carlos III (ISCIII CP18/00009), co-funded by the European Social Fund “Investing in your future”. JS is funded by a predoctoral PERIS contract (SLT002/16/00250) from the Catalan Government. MJ is a professor under the “Serra Hunter” programme (Generalitat de CatalunyaBMJ Publishing Group2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10256/19074http://hdl.handle.net/10256/19074Gut, 2021, First published January 29, 2021.Articles publicats (D-CM)Arnoriaga Rodríguez, María Mayneris Perxchas, Jordi Contreras-Rodríguez, Oren Burokas, Aurelijus Ortega Sanchez, Juan Antonio Blasco Solà, Gerard Coll, Claudia Biarnés, Carles Castells Nobau, Anna Puig, Josep Garre Olmo, Josep Ramos Blanes, Rafel Pedraza Gutiérrez, Salvador Brugada, Ramon Vilanova Busquets, Joan Carles Serena, Joaquín Barretina, Jordi Gich Fullà, Jordi Pérez Brocal, Vicente Moya, Andrés Fernández-Real, Xavier Ramió i Torrentà, Lluís Pamplona, Reinald Sol, Joaquim Jové, Mariona Ricart, Wilfredo Portero Otin, Manuel Maldonado, Rafael Fernández-Real Lemos, José Manuel 2021 Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways Gut undef undefreponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1136/gutjnl-2020-323371info:eu-repo/semantics/altIdentifier/issn/0017-5749info:eu-repo/semantics/altIdentifier/eissn/1468-3288Reconeixement-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessoai:recercat.cat:10256/190742026-05-29T05:05:01Z
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