Metabolic and Clinical Outcomes in Type 1 Diabetes in the COVID-19 Pre- and Post-Vaccination Periods in Spain

Aims: To evaluate the metabolic and clinical outcomes in the Spanish type 1 diabetes mellitus (T1D) population before and after COVID-19 vaccination. Methods: A retrospective observational study was carried out in Spanish public hospitals previously enrolled in the SED1 study. Adults and children wi...

Descripción completa

Detalles Bibliográficos
Autores: Gómez-Peralta, Fernando|||0000-0003-0106-0091, Menéndez Torre, Edelmiro|||0000-0002-9548-7821, Conde, Santiago, Abellán-Galiana, Pablo|||0000-0003-1221-3946, Brito, Miguel, Beléndez, Marina|||0000-0002-5567-1069, Pérez, Antonio|||0000-0001-5528-1143
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:305891
Acceso en línea:https://ddd.uab.cat/record/305891
https://dx.doi.org/urn:doi:10.3390/jcm13071922
Access Level:acceso abierto
Palabra clave:COVID-19
Continuous glucose monitoring
Diabetes complications
Glycemic control
Type 1 diabetes
Vaccination
id ES_8e1791df1cb859f3a0e1fee3a3dfd62a
oai_identifier_str oai:ddd.uab.cat:305891
network_acronym_str ES
network_name_str España
repository_id_str
spelling Metabolic and Clinical Outcomes in Type 1 Diabetes in the COVID-19 Pre- and Post-Vaccination Periods in SpainThe COVID-SED1 StudyGómez-Peralta, Fernando|||0000-0003-0106-0091Menéndez Torre, Edelmiro|||0000-0002-9548-7821Conde, SantiagoAbellán-Galiana, Pablo|||0000-0003-1221-3946Brito, MiguelBeléndez, Marina|||0000-0002-5567-1069Pérez, Antonio|||0000-0001-5528-1143COVID-19Continuous glucose monitoringDiabetes complicationsGlycemic controlType 1 diabetesVaccinationAims: To evaluate the metabolic and clinical outcomes in the Spanish type 1 diabetes mellitus (T1D) population before and after COVID-19 vaccination. Methods: A retrospective observational study was carried out in Spanish public hospitals previously enrolled in the SED1 study. Adults and children with T1D were included and their clinical electronic records were reviewed. Clinical, laboratory, and glucometric parameters from continuous glucose monitoring (CGM) data corresponding to the periods before and after administering the first COVID-19 vaccination were analyzed. Results: A total of 26 centers and 228 patients participated in this new phase of the SED1 study and 187 were finally evaluable (mean age 37.5 ± 15.6 years, 56.7% women). Overall, 94.6% of the sample was vaccinated, and this percentage increased with higher levels of education (p-value = 0.027). In the pre- and post-vaccination periods, respectively, the number of patients with acute hyperglycemic decompensation was 6/161 (3.7%) and 7/161 (4.3%) (p = 1) and with acute hypoglycemic decompensation was 6/161 (3.7%) and 6/161 (3.7%) (p = 1). The HbA1c level was lower in the post-vaccination period(mean ± SD, mg/dL): pre-vaccination 7.4 ± 0.9; post-vaccination 7.2 ± 1.0, (-0.19; p-value = 0.0006). A total of 31.9% of patients (95% CI: 24.7-39.7) in the pre-vaccination period and 45.0% (IC95%: 37.1-53.1) in the post-vaccine period had HbA1c < 7% (p-value < 0.001). Glucometrics from CGM data also showed numerical improvements post-vaccination. Conclusions: The COVID-19 vaccination was highly accepted in the Spanish T1D population, with hesitancy about the COVID-19 vaccine being higher in those with lower educational levels. A mildly better glycemic control was observed in the post-vaccination period.Universitat Autònoma de Barcelona 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/305891https://dx.doi.org/urn:doi:10.3390/jcm13071922reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3058912026-06-06T12:50:31Z
dc.title.none.fl_str_mv Metabolic and Clinical Outcomes in Type 1 Diabetes in the COVID-19 Pre- and Post-Vaccination Periods in Spain
The COVID-SED1 Study
title Metabolic and Clinical Outcomes in Type 1 Diabetes in the COVID-19 Pre- and Post-Vaccination Periods in Spain
spellingShingle Metabolic and Clinical Outcomes in Type 1 Diabetes in the COVID-19 Pre- and Post-Vaccination Periods in Spain
Gómez-Peralta, Fernando|||0000-0003-0106-0091
COVID-19
Continuous glucose monitoring
Diabetes complications
Glycemic control
Type 1 diabetes
Vaccination
title_short Metabolic and Clinical Outcomes in Type 1 Diabetes in the COVID-19 Pre- and Post-Vaccination Periods in Spain
title_full Metabolic and Clinical Outcomes in Type 1 Diabetes in the COVID-19 Pre- and Post-Vaccination Periods in Spain
title_fullStr Metabolic and Clinical Outcomes in Type 1 Diabetes in the COVID-19 Pre- and Post-Vaccination Periods in Spain
title_full_unstemmed Metabolic and Clinical Outcomes in Type 1 Diabetes in the COVID-19 Pre- and Post-Vaccination Periods in Spain
title_sort Metabolic and Clinical Outcomes in Type 1 Diabetes in the COVID-19 Pre- and Post-Vaccination Periods in Spain
dc.creator.none.fl_str_mv Gómez-Peralta, Fernando|||0000-0003-0106-0091
Menéndez Torre, Edelmiro|||0000-0002-9548-7821
Conde, Santiago
Abellán-Galiana, Pablo|||0000-0003-1221-3946
Brito, Miguel
Beléndez, Marina|||0000-0002-5567-1069
Pérez, Antonio|||0000-0001-5528-1143
author Gómez-Peralta, Fernando|||0000-0003-0106-0091
author_facet Gómez-Peralta, Fernando|||0000-0003-0106-0091
Menéndez Torre, Edelmiro|||0000-0002-9548-7821
Conde, Santiago
Abellán-Galiana, Pablo|||0000-0003-1221-3946
Brito, Miguel
Beléndez, Marina|||0000-0002-5567-1069
Pérez, Antonio|||0000-0001-5528-1143
author_role author
author2 Menéndez Torre, Edelmiro|||0000-0002-9548-7821
Conde, Santiago
Abellán-Galiana, Pablo|||0000-0003-1221-3946
Brito, Miguel
Beléndez, Marina|||0000-0002-5567-1069
Pérez, Antonio|||0000-0001-5528-1143
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv COVID-19
Continuous glucose monitoring
Diabetes complications
Glycemic control
Type 1 diabetes
Vaccination
topic COVID-19
Continuous glucose monitoring
Diabetes complications
Glycemic control
Type 1 diabetes
Vaccination
description Aims: To evaluate the metabolic and clinical outcomes in the Spanish type 1 diabetes mellitus (T1D) population before and after COVID-19 vaccination. Methods: A retrospective observational study was carried out in Spanish public hospitals previously enrolled in the SED1 study. Adults and children with T1D were included and their clinical electronic records were reviewed. Clinical, laboratory, and glucometric parameters from continuous glucose monitoring (CGM) data corresponding to the periods before and after administering the first COVID-19 vaccination were analyzed. Results: A total of 26 centers and 228 patients participated in this new phase of the SED1 study and 187 were finally evaluable (mean age 37.5 ± 15.6 years, 56.7% women). Overall, 94.6% of the sample was vaccinated, and this percentage increased with higher levels of education (p-value = 0.027). In the pre- and post-vaccination periods, respectively, the number of patients with acute hyperglycemic decompensation was 6/161 (3.7%) and 7/161 (4.3%) (p = 1) and with acute hypoglycemic decompensation was 6/161 (3.7%) and 6/161 (3.7%) (p = 1). The HbA1c level was lower in the post-vaccination period(mean ± SD, mg/dL): pre-vaccination 7.4 ± 0.9; post-vaccination 7.2 ± 1.0, (-0.19; p-value = 0.0006). A total of 31.9% of patients (95% CI: 24.7-39.7) in the pre-vaccination period and 45.0% (IC95%: 37.1-53.1) in the post-vaccine period had HbA1c < 7% (p-value < 0.001). Glucometrics from CGM data also showed numerical improvements post-vaccination. Conclusions: The COVID-19 vaccination was highly accepted in the Spanish T1D population, with hesitancy about the COVID-19 vaccine being higher in those with lower educational levels. A mildly better glycemic control was observed in the post-vaccination period.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/305891
https://dx.doi.org/urn:doi:10.3390/jcm13071922
url https://ddd.uab.cat/record/305891
https://dx.doi.org/urn:doi:10.3390/jcm13071922
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413100231327744
score 15,228081

Similares en LA Referencia